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Preparation method of mono-ammonium glycyrrhizinate

A technology of glycyrrhizic acid monoammonium salt and glycyrrhizic acid is applied in the preparation of sugar derivatives, chemical instruments and methods, steroid compounds, etc., and can solve the problems of low industrialization degree of the preparation process and insufficient purity of the finished product, and achieves excellent color and luster. The effect of good quality and high product purity

Inactive Publication Date: 2015-11-18
JIANGSU TIANSHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology allows create pure or highly concentrated forms of certain compounds called glyceryltronate that have benefiting health benefits such as reducing blood pressure without losing weight. These products also improve skin appearance while maintaining their effectiveness over time.

Problems solved by technology

This technical problem addressed by this patented technology relates to improving the quality and efficiency of producing pure single ammoniumsulfonate (SSA) with desired properties for use in medical treatments like medicines and nutraceuticals.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 1) Test steps:

[0025] (1) Extract glycyrrhizic acid with 3 times its volume, 2 times its volume, and 1 times its volume of acidic ethanol with a concentration of 90% and a pH of 4.5 at 60°C-70°C, the extraction time is 2 hours, and filter separately after extraction , to obtain three parts of extracts, and mix the three parts of extracts evenly;

[0026] (2) Concentrate the uniformly mixed extract above at 80°C until the concentration of acidic ethanol is 82%, and the concentration is controlled by calculating the volume of water to be concentrated, adding ammonia water to adjust the pH to 5.0, and centrifuging statically to obtain licorice Acid monoammonium salt crude product;

[0027] (3) Add 75% acidic ethanol substance and activated carbon to the crude product of glycyrrhizinate monoammonium salt obtained above, stir, heat and reflux at 60°C for decolorization, settle and filter to obtain a wet product of glycyrrhizinate monoammonium salt;

[0028] (4) Dissolve ...

Embodiment 2

[0035] 1) Test steps:

[0036] (1) Extract glycyrrhizic acid with 3 times volume, 2 times volume, and 1 times volume of acidic ethanol with a concentration of 90%-95% and a pH of 5.0 at 70°C for 2 hours, and filter separately after extraction , to obtain three parts of extracts, and mix the three parts of extracts evenly;

[0037] (2) Concentrate the uniformly mixed extract at 80°C in vacuum until the concentration of acidic alcohols is 86%, add ammonia water to adjust the pH to 5.5, and centrifuge statically to obtain the crude product of monoammonium glycyrrhizinate;

[0038] (3) Add 80% acidic ethanol substance and activated carbon to the crude product of monoammonium glycyrrhizinate obtained above, stir, heat and reflux at 70°C for decolorization, settle and filter to obtain a wet product of monoammonium glycyrrhizinate;

[0039] (4) Dissolve the wet product of monoammonium glycyrrhizinate obtained above into purified water of 3 times its volume, mix the purified water wi...

Embodiment 3

[0046] 1) Test steps:

[0047] (1) Extract glycyrrhizic acid with 3 times volume, 2 times volume, and 1 times volume of acidic ethanol with a concentration of 90%-95% and a pH of 4.8 at 65°C for 2 hours, and filter separately after extraction , to obtain three parts of extracts, and mix the three parts of extracts evenly;

[0048] (2) Concentrate the homogeneously mixed extract above at 80°C until the concentration of acidic alcohols is 84%, and the concentration is controlled by calculating the volume of water to be concentrated, adding ammonia water to adjust the pH to 5.3, and centrifuging statically Obtain the crude product of monoammonium glycyrrhizinate;

[0049] (3) Add 78% acidic ethanol substance and activated carbon to the crude product of glycyrrhizinate monoammonium salt obtained above, stir, heat and reflux at 65°C for decolorization, settle and filter to obtain a wet product of glycyrrhizinate monoammonium salt;

[0050] (4) Dissolve the wet product of monoammo...

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Abstract

The invention discloses a preparation method of mono-ammonium glycyrrhizinate. Glycyrrhizinate is extracted for multiple times with acidic alcohol substances, and the high-purity mono-ammonium glycyrrhizinate is obtained by means of crystallization and centrifugation technologies; compared with the prior art, the method has the obvious advantages as follows: a) the product purity is high: in terms of a dry product, the purity of the obtained mono-ammonium glycyrrhizinate can be higher than 98% and breaks through the purity of existing products; b) characters are good: the product is excellent in color and uniform in crystal; c) the formula is reasonable and practical: the property that the mono-ammonium glycyrrhizinate is dissolved in an organic solvent easily and the property that impurities are dissolved in water easily are used, the formula is scientific, reasonable and practical, and the quality can be guaranteed; d) the preparation technology is simple, the quality is good, the purity is high, and most importantly, the method is applicable to industrial production.

Description

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Claims

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Application Information

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Owner JIANGSU TIANSHENG PHARMA
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