Novel anti-tumor compound in saxifraga tangutica

A technology of Tanggut tiger ear and compound, which is applied in the field of medicine and achieves the effects of simple preparation method, reduced pollution and low average cost

Inactive Publication Date: 2015-11-25
CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the compounds with anti-tumor activity compounds obtained from Saxifrage tangutata have not been reported in the literature.

Method used

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  • Novel anti-tumor compound in saxifraga tangutica
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  • Novel anti-tumor compound in saxifraga tangutica

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 A preparation method of a new anti-tumor compound in saxifrage tangutata, comprising the following steps:

[0025] (1) Extraction: Dry 3.0Kg of saxifrage whole herb in the shade, crush it to 50 meshes, soak it in an ethanol solution with a volume concentration of 10 times its mass and a concentration of 50% for 10 hours, and then heat and reflux at 80°C for 4 extractions. Concentrate under reduced pressure for 3 hours each time, and recover ethanol to obtain 146.2 g of saxifrage extract with a specific gravity of 1.0.

[0026] (2) Separation and purification: Dissolve the saxifrage extract of Tangutia saxifrage extract in methanol solution with 10 times its mass and 50% volume concentration, then use XAquaC3 preparative column for preparative liquid chromatography separation, and collect fractions of 79~86min; Then use the XAquaC18 preparative column for preparative liquid chromatography separation, and collect the second main component to obtain the compoun...

Embodiment 2

[0029] Example 2 A preparation method of a new anti-tumor compound in saxifrage tangutata, comprising the following steps:

[0030] (1) Extraction: Dry 1.0Kg of the whole saxifrage herb in the shade, crush it to 80 mesh, soak it in an ethanol solution with a volume concentration 20 times its mass of 50% for 15 hours, and then heat and reflux at 90°C for 2 extractions. Concentrate under reduced pressure for 3 hours each time, and recover ethanol to obtain 50.6 g of saxifrage extract with a specific gravity of 1.5.

[0031] (2) Separation and purification: Dissolve the saxifrage extract of Tangutia saxifrage extract in methanol solution with 20 times its mass and 30% volume concentration, then use XAquaC3 preparative column for preparative liquid chromatography separation, and collect fractions of 79~86min; Then use the XAquaC18 preparative column for preparative liquid chromatography separation, and collect the second main component to obtain the compound (5S)-1,7-bis-(3,4-di...

Embodiment 3

[0033] Example 3 A preparation method of a new anti-tumor compound in saxifrage tangutata, comprising the following steps:

[0034] (1) Extraction: Dry 2.0Kg of the whole saxifrage herb in the shade, crush it to 120 mesh, soak it in an ethanol solution with a volume concentration 15 times its mass and a volume concentration of 50% for 12 hours, and then heat and reflux at 85°C for 3 times. Concentrate under reduced pressure for 3 hours each time, and recover ethanol to obtain 100.6 g of saxifrage extract with a specific gravity of 1.2.

[0035] (2) Separation and purification: Dissolve Tangutia saxifrage extract in methanol solution with 15 times its mass and 40% volume concentration, then use XAquaC3 preparative column for preparative liquid chromatography separation, and collect fractions of 79~86min; Then use the XAquaC18 preparative column for preparative liquid chromatography separation, and collect the second main component to obtain the compound (5S)-1,7-bis-(3,4-dihy...

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PUM

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Abstract

The invention relates to a novel anti-tumor compound in saxifraga tangutica. The compound is brown powder, and is named (5S)-1,7-bis-(3,4-dihydroxyphenyl)-5-hydroxyheptane-3-on-5-O-beta-D-6-acetylglucoside, and has a molecular formula of C27H34O12 and a chemical structure as shown in the specification. The compound is simple in preparation method and low in average cost, and can be applied to preparation of anti-tumor medicines.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a new anti-tumor compound in saxifrage tangutiae. Background technique [0002] Tangut saxifrage ( Saxifraga tangutica Engl.) is the genus Saxifragaceae (Saxifragaceae) ( Saxifraga ) plant, Tibetan medicine name: Songjidi, which is called Dida in traditional Chinese medicine, mainly distributed in Qinghai, Gansu, Tibet, Sichuan, and Bhutan and Kashmir under the coniferous forest shrubs at an altitude of 2900~4900m. Tangutia saxifrage is a commonly used Tibetan medicine. It tastes bitter and cool, clears away heat, treats liver, gallbladder fever and trauma, and can also treat acute otitis media and wind-heat cough. Modern pharmacological studies have shown that Tangutia saxifrage has antibacterial , antiviral, anti-inflammatory and anti-tumor pharmacological effects. [0003] So far, the only research report on saxifrage tangutata is the article "Study on the Chemical Consti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H15/18C07H1/08A61K31/7032A61P35/00
Inventor 党军张莉邵赟梅丽娟王启兰陶燕铎文怀秀
Owner CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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