Application of TIPE2 (tumor necrosis factor-alpha induced protein 8 like-2) agonist in protection on sepsis complicated with acute lung injury

An acute lung injury and agonist technology, applied in the field of medicine, can solve problems such as less consideration of immune system changes, and achieve obvious effects

Inactive Publication Date: 2015-12-09
安徽济人药业股份有限公司
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Problems solved by technology

Abnormal activation of the body's immune system in sepsis complicated with acute lung injury plays an important role in its pathogenesis, but curr...

Method used

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  • Application of TIPE2 (tumor necrosis factor-alpha induced protein 8 like-2) agonist in protection on sepsis complicated with acute lung injury
  • Application of TIPE2 (tumor necrosis factor-alpha induced protein 8 like-2) agonist in protection on sepsis complicated with acute lung injury
  • Application of TIPE2 (tumor necrosis factor-alpha induced protein 8 like-2) agonist in protection on sepsis complicated with acute lung injury

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Embodiment Construction

[0017] In order to make the technical means, creative features, goals and effects achieved by the present invention easy to understand, the present invention will be further elaborated below in conjunction with specific embodiments, but the following embodiments are only preferred embodiments of the present invention, not all. Based on the examples in the implementation manners, other examples obtained by those skilled in the art without making creative efforts all belong to the protection scope of the present invention.

[0018] The rat model used in the experiment was SPF (Specificpathogen Free) grade SD (Sprague-Dawley) rats, male, 8-10 weeks old, weighing 220-250 g, purchased from the Experimental Animal Center of Fudan University School of Medicine.

[0019] 1. Pathological evidence of the protective effect of TIPE2 agonist on endotoxin-induced sepsis complicated with acute lung injury in rats

[0020] Through HE conventional pathological staining examination of rat lung ...

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Abstract

The invention relates to the technical field of medicine, in particular to an application of a TIPE2 (tumor necrosis factor-alpha induced protein 8 like-2) agonist in immunoregulation drugs for treating endotoxin sepsis complicated with acute lung injury. A model of the endotoxin sepsis complicated with acute lung injury is established, the protection effect testing of the TIPE2 agonist on the sepsis complicated with acute lung injury is performed, and the regulating function of a TIPE2 agonist on the sepsis immune system is achieved, so that the organism damage caused by excessive activation of the immune system can be prevented. According to the invention, exact laboratory data is provided for treatment of sepsis complicated with acute lung injury by the aid of the TIPE2 agonist, and corresponding scientific basis is further provided for an immunomodulatory therapeutic mechanism with the application of the TIPE2 agonist clinically.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of TIPE2 agonists in protecting sepsis complicated with acute lung injury. Background technique [0002] At present, sepsis refers to the systemic inflammatory response syndrome caused by infection. There are more than 18 million cases of severe sepsis in the world every year, and there are 750,000 sepsis patients in the United States every year, and this number is still at an annual rate of 1.5%. An 8.0% rate increase. Sepsis is a dangerous condition, with a higher fatality rate than myocardial infarction. It has become the main cause of death of non-cardiac patients in the intensive care unit. The resulting sepsis combined with acute lung injury is one of the main causes of death in patients. Sepsis complicated with acute lung injury is often accompanied by abnormal activation of the body's immune system and multiple organ failure, which plays a leading role i...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61P11/00A61P31/04A61P31/12A61P31/16A61K31/7032A61K31/7048A61K31/122
Inventor 陶振钢朱强朱月信张亚平黄超兰薛明明顾国嵘王春兰宋振举
Owner 安徽济人药业股份有限公司
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