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A gel biomaterial with shape memory function and preparation method thereof

A biomaterial and gel technology, applied in medical science, prosthesis, etc., can solve the problems of limited clinical application, inconvenient operation, brittle and fragile quality, etc., and achieve improved mechanical properties, slow down degradation rate, good adhesion and growth Effect

Inactive Publication Date: 2019-04-23
ARMY MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the above-mentioned hydrogels still have deficiencies: first, its composition is only composed of collagen, and its structural composition is different from that of the natural extracellular matrix; second, the physical properties of the hydrogel are brittle and fragile, and it is inconvenient to operate, which limits its application on body surface wounds. Clinical Application in Restoration

Method used

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  • A gel biomaterial with shape memory function and preparation method thereof
  • A gel biomaterial with shape memory function and preparation method thereof
  • A gel biomaterial with shape memory function and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0034] A gel biomaterial prepared by the following method:

[0035] 1. Preparation of porcine small intestinal submucosa extracellular matrix (PSIS)

[0036] Fresh pig small intestines were obtained from pig farms. First, the serosal layer and muscular layer of the small intestine were removed by mechanical means, and rinsed with normal saline repeatedly. Soak in a degreasing solution of methanol and chloroform (1:1, V / V) for 12 hours, and use deionized water to remove the organic solvent. Subsequently, the SIS was soaked in 0.05% trypsin / 0.05% ethylenediaminetetraacetic acid solution, digested at room temperature for 12 hours, and washed repeatedly with physiological saline solution to remove trypsin. The SIS was shaken in 0.5% sodium dodecyl sulfate (SDS) saline for 4 hours, and rinsed thoroughly with saline solution to remove the detergent. The treated SIS was soaked in 0.5% acetic acid solution overnight, pulverized with a beater, hydrolyzed with pepsin at room temperatu...

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Abstract

The invention provides a gel biological material, wherein the gel biological material is prepared from a small intestinal submucosa extracellular matrix; the gel biological material is characterized in that the gel biological material is of a porous structure that pores are mutually communicated; and the gel biological material can recover to original form when the volume is compressed by more than 85%. The major ingredient of the gel biological material disclosed by the invention is close to a natural extracellular matrix ingredient in structure; the gel biological material has an elastic deformation capacity and a shape memory function, and has a good mechanical performance; and meanwhile, the gel biological material is relatively good in biocompatibility and is suitable to be used as a tissue regenerating repair material in clinical field.

Description

technical field [0001] The invention belongs to the field of biomaterials, and in particular relates to a gel biomaterial with a shape memory function, which is especially suitable for repairing skin wounds. Background technique [0002] Burns, wounds, diabetes, chronic ulcers and other causes often cause skin defects. Cell therapy is the most effective treatment for skin defects / absences and skin pigmentation diseases. After obtaining clinical-grade cells in large-scale culture, how to effectively apply them to the body for treatment and maintain their vitality and activity is the key to the success of cell therapy. The essential 1 . [0003] The basic structure of human tissue is composed of cells and extracellular matrix, and the interaction between cells and extracellular matrix is ​​the key to the regeneration and repair of wounded tissues. Human extracellular matrix is ​​restricted by sources and ethics, and its use is limited, while animal extracellular matrix, whi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/36A61L27/56A61L27/52A61L27/60A61L27/58
Inventor 曹川葛良鹏李世荣廖建贵刘弓伯朱宁文
Owner ARMY MEDICAL UNIV
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