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Hemocompatibility modifiers for cross-linked polymeric material

A technology of cross-linking polymers and blood, which can be used in blood circulation treatment, preservation of human or animal bodies, blood filtration, etc., and can solve problems such as limitations

Inactive Publication Date: 2015-12-23
CYTOSORBENTS CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Standard hemodialysis, hemofiltration, and charcoal hemoperfusion techniques are limited in the toxins they remove

Method used

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  • Hemocompatibility modifiers for cross-linked polymeric material
  • Hemocompatibility modifiers for cross-linked polymeric material
  • Hemocompatibility modifiers for cross-linked polymeric material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Example 1: Carboxybetainemethacrylate (CMBA) coated polymer

[0052] A 500ml resin kettle was equipped with a water cooled condenser, thermocouple, bubbler and magnetic stir bar. A liner is installed between the top lid and the bottom pot. All unused ports have been capped with suitable plugs. The temperature was controlled with a heating mantle regulated by a temperature controller equipped with the aforementioned thermocouple, and the entire setup was placed on a magnetic stir plate.

[0053] All reagents were ordered from Sigma-Aldrich and used without further purification.

[0054] Hydroquinone (0.038 g) was added to the resin pot, followed by 76% ultrapure H of acrylic acid 2 O solution (10.0 g). The mixture was stirred until all hydroquinone was dissolved, then N,N-dimethylaminomethacrylate (16.52 g) was added dropwise via syringe. The reaction was exothermic, the mixture was heated to 50°C and a white gas was evolved. The reaction was heated to 70 °C for 4 ...

Embodiment 2

[0058] Example 2: Oligo(ethylene glycol) methacrylate (OEGMA) coated polymer

[0059] The 500ml resin pot was equipped with a water-cooled condenser, thermocouple, bubbler and multi-stage stirring blades. A liner is installed between the top lid and the bottom pot. All unused ports have been capped with suitable plugs. The temperature was controlled with a heating mantle regulated by a temperature controller equipped with the above-mentioned thermocouple.

[0060] Then, the reactor was charged with H 2 Divinylbenzene porous resin CY12018 (100-144) (200ml), OEGMA (6.0g) in O (200ml), heated to 80°C and stirred for 30 minutes, at which point ammonium persulfate (2.0g) was added. The reaction was allowed to stir at 80 °C for 16 hours.

[0061] After cooling, the solvent was siphoned off until the level of the beads. Fill the reactor to mark with RT water, heat to 70 °C and stir for 30 minutes, allow to stand for 3 to 5 minutes, then siphon off until bead level. The beads we...

Embodiment 3

[0063] Example 3: Additional polymer coatings

[0064] Example 1 was repeated using one or more of the following as monomers and 2-methacryloyloxyethyl phosphorylcholine: sulfobetaine methacrylate, N-(2-hydroxy-3 -sulfopropyl)vinylpyridine Betaine, N,N-Dimethyl-N-(2-methacryloyloxyethyl)-N-(3-sulfopropyl)ammonium betaine, N,N-Dimethyl-N- (3-methacrylamidopropyl)-N-(3-sulfopropyl)ammonium betaine, N,N-dimethyl-N-(2-methacryloyloxyethyl)-N -(carboxymethyl)ammonium betaine, N,N-dimethyl-N-(2-methacryloyloxyethyl)-N-(2-phosphoethyl)ammonium betaine.

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Abstract

The invention concerns methods of treating blood, blood product, or physiologic fluid to provide at least one of (i) increasing shelf life of the blood, blood product or physiologic fluid, (ii) maintaining freshness of new blood, blood product or physiologic fluid, and (iii) removing undesirable molecules from the blood, blood product or physiologic fluid; said method comprising contacting said blood, blood product or physiologic fluid with a sorbent, said sorbent being primarily in a plurality of solid forms and comprising a cross-linked polymeric material having a plurality of at least one of (1) zwitterionic moieties and (2) oligo(ethylene glycol) moieties attached to the surface of said cross-linked polymeric material.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Provisional Application No. 61 / 806,990, filed April 1, 2013, the entire contents of which are incorporated herein by reference. [0003] government rights [0004] This material is based on work supported by DARPA and SSCPacific under Contract No. N66001-12-C-4199. Accordingly, the US Government may have rights in the inventions described herein. technical field [0005] The present invention relates to methods useful for one or more of the following: extending the shelf life of blood, blood products or physiologic fluids through the use of hemocompatibility-modified cross-linked polymeric materials ; maintaining the freshness of new blood, blood products or physiological fluids; and removing undesired molecules from blood, blood products or physiological fluids. Background technique [0006] Transfusion of whole blood or whole blood derivatives ("blood products") is truly a...

Claims

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Application Information

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IPC IPC(8): A61M1/34
CPCA61M1/0272B01J20/28069B01J20/28092B01J20/3208B01J20/3282B01J20/3285B01J2220/62B01J20/28078A01N1/02A01N1/0215B01J20/261B01J20/267B01J20/3246A61M1/36B01J20/3248B01J20/3251B01J20/3272A61M1/3679A61M1/34
Inventor 托马斯·D·戈洛比什文森特·J·卡波尼大卫·R·克莱
Owner CYTOSORBENTS CORP