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A method for preparing matrine and sophoridine in Sophora sophora

A technology of Sophora fragrans and matrine, which is applied in the field of preparation of medicinal active ingredients, can solve the problems of complicated operation steps, low monomer alkaloid content of Sophora japonica and high production cost, and achieves reduction of production cost and toxicity and low price. , the effect of increasing the purity

Inactive Publication Date: 2017-03-29
陈卫斌 +1
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  • Summary
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  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The extraction solvent of the above method uses a large amount of toxic solvents, the production cost is high, the operation steps are complicated, and the content of monomeric alkaloids of Sophora sophora is relatively low

Method used

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  • A method for preparing matrine and sophoridine in Sophora sophora

Examples

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Effect test

example 1

[0030] (1) Take the whole herb of Sophora sophora, crush it and pass it through a 12-mesh sieve to get the powder of Sophora sophora, use 10 times the dry weight of Sophora sophora powder (w / w) of 70% ethanol aqueous solution with pH=3, add excess sodium Sodium bisulfate, extracted 3 times at 60°C, each time for 1 hour, combined the filtrates three times, then concentrated under reduced pressure, recovered the organic solvent and dried to obtain the extract, which is the total alkali extract of Sophora aphorae;

[0031](2) Sophora sophorae total alkali extract is used as raw material, add 70% ethanol aqueous solution with a weight ratio of 1:2 to dissolve, add ammonia water to adjust PH = 9, filter, and then use macroporous adsorption resin AB-8 resin to enrich and adsorb to Saturation, first use not less than 2 times the amount of water (v / v) to wash away non-alkaloid large polar impurities, 20% ethanol aqueous solution with 2 times the amount of resin at a flow rate of 1 time...

example 2

[0035] (1) Take the whole herb of Sophora sophora, crush it and pass it through a 12-mesh sieve to get the powder of Sophora sophora, use 70% ethanol aqueous solution with pH=2 of 15 times the dry weight of Sophora sophora powder (w / w), add excess sulfur to the aqueous ethanol solution Sodium persulfate, extracted 3 times at 60°C, each time for 1 hour, combined the filtrates three times, then concentrated under reduced pressure, recovered the organic solvent and dried to obtain the extract, which is the total alkali extract of Sophora aphorae;

[0036] (2) Sophora sophorae total alkali extract as raw material, add 70% ethanol aqueous solution with a weight ratio of 1:2 to dissolve, add ammonia water to adjust PH = 10, filter, and then use D-101 resin to enrich and absorb to saturation. Less than 2 times the amount of water (v / v) to wash away non-alkaloid large polar impurities, 20% ethanol aqueous solution with 2 times the amount of resin to wash away the polarity at a flow rat...

example 3

[0040] (1) Take the whole herb of Sophora sophora, crush it through a 12-mesh sieve to get the powder of Sophora sophora, use 10 times the dry weight of Sophora sophora powder (w / w) and 70% ethanol aqueous solution with pH=2, add excess Sodium thiosulfate, extracted 3 times at 60°C, each time for 1 hour, combined the filtrates three times, then concentrated under reduced pressure, recovered the organic solvent and dried to obtain the extract, which is the total alkali extract of Sophora aphorae;

[0041] (2) Sophora sophorae total alkali extract is used as raw material, dissolved in 60% ethanol aqueous solution with a weight ratio of 1:2 at pH=3, adjusted to pH=9 with ammonia water, filtered, and then enriched and adsorbed with macroporous adsorption resin SP850 to Saturation, first use not less than 2 times the amount of water (v / v) to wash away non-alkaloid large polar impurities, 1 times the amount of resin in 20% ethanol aqueous solution at a flow rate of 1 times the amount...

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Abstract

The invention provides a method for preparing matrine and sophoridine in sophora alopecuroides by adopting macroporous adsorption resin. The method comprises the following steps: extracting sophora alopecuroide total alkali liquor from the sophora alopecuroides by using an acidic polar organic solvent aqueous solution containing a reducing agent; performing alkalization, and then adsorbing with the macroporous adsorption resin until the resin is saturated; cleaning residual feed liquid and water-soluble impurities which are not adsorbed by the resin by using water; eluting a target product by using a polar organic solvent aqueous solution; performing reduced pressure recovery of a solvent from a filtrate; purifying to obtain a matrine crude extract and a sophoridine crude extract; and performing crystallization and recrystallization purification on the matrine crude extract and the sophoridine crude extract to obtain a matrine high-quality product and a sophoridine high-quality product. The success of the method provided by the invention is that the macroporous adsorption resin is applied to separation of sophora alopecuroide alkaloid, and the method is simple in process, is safe and nontoxic, is low in production cost, can be used for industrial production, and has great economic benefit and high generalization performance.

Description

technical field [0001] The invention relates to a preparation method of medicinal active ingredients in Sophora Sophorae, in particular to a preparation method of matrine and sophoidine, which are medicinal active ingredients in Sophora Sophora. Background technique [0002] bitter beans ( Sophora alopecuroides L), synonymous Buya (dimensional name), is the whole herb and seeds of Sophora sophora in the leguminous family, and is a commonly used traditional Chinese medicine in Northwest my country. Its medicinal parts are roots, stems, whole plants and seeds, which are bitter in taste and cold in nature, and have the functions of clearing heat and detoxifying, expelling wind and dampness, relieving pain and killing insects. The content of alkaloids in the seeds of Sophora sophora is relatively high, about 8.11% (mass fraction), mainly including matrine, aloperine, sophocarpine, sophoridine and so on. [0003] In recent years, studies at home and abroad have shown that tota...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D471/22
CPCC07D471/22
Inventor 王炎王奇田玉欣陈晓怡白少娟赵怡程
Owner 陈卫斌
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