A kind of emulsion for treating onychomycosis and preparation method thereof

A technology of onychomycosis and emulsion, applied in the field of pharmacy, can solve problems such as nail trauma or impact, careless personal hygiene, fungal invasion, etc., and achieve the effects of strong permeability, inhibiting fungal reproduction, and preventing fungal infection

Active Publication Date: 2019-03-12
湖北一匠药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] 1. Not paying attention to personal hygiene; 2. Suffering from tinea pedis; 3. Long-term direct contact with water or chemicals; 4. Malnutrition; 5. Trauma or impact on nails may lead to fungal invasion; (Onychomycosis) patient contact
[0006] 2. Environmental factors

Method used

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  • A kind of emulsion for treating onychomycosis and preparation method thereof
  • A kind of emulsion for treating onychomycosis and preparation method thereof
  • A kind of emulsion for treating onychomycosis and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0047] 1 Preparation of fennel extract

[0048] Take 15g of Sophora flavescens, crush it into a coarse powder, and extract it three times: add 200ml 0.2% hydrochloric acid for the first time, soak for 30min, extract by reflux extraction for 2h, collect the extract by filtration, add 150ml 0.2% hydrochloric acid to the filter residue for 2h for the second extraction , collect the extract by filtration, add 120ml 0.2% hydrochloric acid to the filter residue for the third time to extract for 1h, combine the three filtrates, mix and concentrate to 90ml.

[0049] 2 Preparation of Sophora flavescens extract

[0050] Take 15g of fennel, crush it into a coarse powder, and extract it three times: first add 300ml 75% ethanol to soak for 30min, use reflux extraction method to extract for 1.5h, collect the extract, add 200ml 75% ethanol to the filter residue for the second time to extract for 1h, Collect the extract, add 150ml 75% ethanol to the filter residue for the third time to extra...

Embodiment 1

[0052] The preparation method of treating onychomycosis emulsion

[0053] a) Weigh 0.04g of sodium alginate, disperse it in 10ml of distilled water, and fully swell into a transparent gel A:

[0054] b) Weigh 0.05g of sodium carboxymethylcellulose, disperse it in 6ml of distilled water, and fully swell into a transparent gel B:

[0055] c) Weigh 0.06g of hydroxypropyl methylcellulose, disperse it in 6ml of distilled water, and fully swell into a transparent gel C:

[0056] d) Weigh 1.0g of eucalyptus oil, 0.7g of zedoary oil, 0.6g of javanica javanica oil, 1.0g of self-emulsifying compound emulsifier AC-402, and 0.5g of olive emulsifier in beaker 1, and heat it in a water bath at 90°C to be used as oil Phase, standby;

[0057] e) Measure 8ml of distilled water in beaker 2, heat it in a water bath at 90°C, and use it as the water phase for later use;

[0058] f) When the oil phase and the water phase reach the same temperature, add the distilled water in the beaker 2 into the ...

Embodiment 2

[0064] The preparation method of treating onychomycosis emulsion

[0065] a) Weigh 0.05 g of sodium alginate, disperse it in 12 ml of distilled water, and fully swell to form a transparent gel A.

[0066] b) Weigh 0.10 g of sodium carboxymethyl cellulose, disperse it in 10 ml of distilled water, and fully swell into a transparent gel B;

[0067] c) Weigh 0.12 g of hydroxypropyl methylcellulose, disperse it in 10 ml of distilled water, and fully swell it into a transparent gel C;

[0068] d) Weigh 0.8g of eucalyptus oil, 0.6g of zedoary oil, 0.6g of javanica javanica oil, 1.0g of self-emulsifying compound emulsifier AC-402, and 0.4g of olive emulsifier in beaker 1, and heat it in a water bath at 80°C as oil Phase, standby;

[0069] e) Measure 10ml of distilled water in beaker 2, heat it in a water bath at 80°C, and use it as the water phase for later use;

[0070] f) When the oil phase and the water phase reach the same temperature, add the distilled water in the beaker 2 in...

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Abstract

The invention discloses an emulsion for treating onychomycosis and a preparation method of the emulsion for treating onychomycosis. The emulsion contains eucalyptus oil, curcuma zedoary oil, oleum fructus bruceae, eugenol, self-emulsifying hybrid emulsifier AC-402, olive emulsifying agent, urea, salicylic acid, camphor, borneol, CMC-Na (sodium carboxyl methyl cellulose), sodium alginate, azone, boric acid, glycerol, hydroxypropyl methyl cellulose, 1,2-propanediol, fennel, lightyellow sophora root and a 5% ethylparaben propanediol solution. The emulsion for treating onychomycosis, prepared by the preparation method, has the advantages that the emulsion is high in functionality and little in toxicity or irritation, wherein the oleum fructus bruceae is capable of inhibiting fungus reproduction and effectively stopping fungal infection, a lightyellow sophora root extracting solution has anti-inflammatory and antibacterial effects, and all ingredients in the formula complement one another; compared with traditional medicines, the emulsion is better in treatment effect, higher in permeability and capable of avoiding relapse more effectively, thereby being capable of fundamentally treating onychomycosis caused by various fungi.

Description

technical field [0001] The invention relates to an emulsion for treating onychomycosis and a preparation method thereof, belonging to the field of pharmacy. Background technique [0002] Onychomycosis caused by fungal infection in real life has become an annoyance to more and more people. For a long time, the diagnosis and treatment methods of onychomycosis are relatively simple, the treatment effect is not satisfactory, and repeated recurrence has become a difficult problem in treatment. [0003] There are three main causes of onychomycosis: personal factors, environmental factors, and disease factors. [0004] 1. Personal factors [0005] 1. Not paying attention to personal hygiene; 2. Suffering from tinea pedis; 3. Long-term direct contact with water or chemicals; 4. Malnutrition; 5. Trauma or impact on nails may lead to fungal invasion; (onychomycosis) patient contact. [0006] 2. Environmental factors [0007] High temperature and high humidity are important conditi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K36/9066A61P31/10A61P17/00
Inventor 孙淑萍朱磊刘金鑫赵天阳唐博安赵雨竹
Owner 湖北一匠药业有限公司
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