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Plant allergy-relieving agent and preparation method thereof

A plant soothing agent and extract technology, which is applied in the directions of drug combination, pharmaceutical formulation, allergic diseases, etc., can solve the problems of less retention of heat-sensitive ingredients, difficulty in applying cosmetics, and reduction in effective ingredients, so as to reduce channeling phenomenon, The color is not easy to change color and the extract is stable

Active Publication Date: 2016-02-03
上海承曜生物科技有限公司
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0004] The preparation of plant compound extracts in the cosmetics industry mainly adopts decoction or external circulation extraction followed by heating, concentration, and aging treatment. The obtained extracts retain less heat-sensitive components, have more impurities, dark and unstable colors, and consume a lot of energy.
[0005] Plant-derived stimulants are generally more from the proven prescriptions of hospitals, which have been proved to be effective after a large number of clinical applications. However, most of these compound prescriptions use a large amount of medicinal materials. Conventional extraction methods such as decoction are used. The color is dark when used, and it needs to be used up in a short time, and the active ingredients will be reduced, precipitated or even deteriorated after being left for a long time, so it is difficult to apply in cosmetics

Method used

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  • Plant allergy-relieving agent and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0045] 30 parts of licorice, 30 parts of Artemisia annua, 10 parts of gentian, 20 parts of flavescens, and 10 parts of cnidium are used as raw materials. Add 5 times of 50% 1,2 propylene glycol, and extract in an extraction tank at 55°C. Such as figure 1 and figure 2 As shown, the expansion bed method and the fixed bed method are alternately extracted for 3 hours, and the expansion bed extraction stage is as follows figure 1 As shown, the fixed bed extraction stage is as figure 2 shown. The bed is fixed for 10 minutes first, followed by alternating 20 minutes of expanded bed-10 minutes of fixed bed, and finally 10 minutes of fixed bed extraction, the expansion of the expanded bed is 1.7 times, after the extraction is completed, filter with a 0.45 μm membrane, and then use a 5000D ultrafiltration The membrane is ultrafiltered under 3bar pressure until the permeate is 70% of the extract A, and the ultrafiltration is stopped, and the permeate is concentrated to 0.5g / ml of cr...

Embodiment 2

[0047] 20 parts of licorice, 20 parts of Artemisia annua, 20 parts of gentian, 20 parts of flavescens, 20 parts of Cnidium, add 8 times of 70% 1,2 propylene glycol, and extract in the extraction tank at 50 °C, such as figure 1 and figure 2 As shown, the expansion bed method and the fixed bed method are alternately extracted for 4 hours. First, the fixed bed is used for 10 minutes, and then the ratio of 10 minutes of expanded bed to 5 minutes of fixed bed is alternated. Finally, the fixed bed method is extracted for 10 minutes. The expansion factor of the expanded bed is 2 times. At the end of the extraction, filter with a 0.22 μm membrane, and then use an 8000D ultrafiltration membrane to perform ultrafiltration at a pressure of 5 bar until the permeate is 80% of the extract A. Stop the ultrafiltration, and use a nanofiltration membrane with a molecular weight cut-off of 150D for the permeate Concentrate to 0.5g / ml equivalent crude drug under 15bar pressure to obtain plant se...

Embodiment 3

[0049] 30 parts of licorice, 20 parts of Artemisia annua, 10 parts of gentian, 20 parts of flavescens, 20 parts of Cnidium, add 6.5 times of 60% 1,2 propylene glycol, and extract in an extraction tank at 40°C, such as figure 1 and figure 2 As shown, the expansion bed method and the fixed bed method are alternately extracted for 3.5 hours, and the bed is fixed for 10 minutes first, and then alternately according to the ratio of 15 minutes of the expanded bed to 7.5 minutes of the fixed bed, and finally the fixed bed method is extracted for 10 minutes, and the expansion factor of the expanded bed is 1.4 After the extraction, use a 0.22 μm membrane to filter, and then use an 8000D ultrafiltration membrane to perform ultrafiltration at a pressure of 4 bar until the permeate is 75% of the initial value. The filter membrane is concentrated to 0.5 g / ml equivalent to the crude drug under 12 bar pressure to obtain the phytosensitizer.

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Abstract

The invention provides a plant allergy-relieving agent and a preparation method thereof. The preparation method comprises the following steps: weighing raw materials according to proportions, and extracting in an extracting device so as to obtain an extracting solution A; filtering the extracting solution A, and reserving permeate liquid as an extracting solution B; and concentrating the extracting solution B so as to obtain a final product, namely the plant allergy-relieving agent. The plant allergy-relieving agent consists of the following raw materials in parts by weight: 20-30 parts of liquorice root, 20-30 parts of artemisia apiacea, 10-20 parts of radix gentianae, 10-20 parts of radix sophorae flavescentis and 10-20 parts of fructus cnidii. The cosmetic plant allergy-relieving agent, which is effective, stable and light in color, is prepared by virtue of a special process; and the prepared plant allergy-relieving agent consists of 0.25-0.35% of glycyrrhizic acid and 0.61-0.87mg / ml of artemisinin in percentage by mass.

Description

technical field [0001] The invention relates to a plant-stimulating agent and a preparation method thereof, in particular to a plant-stimulating agent for cosmetics and a preparation method thereof. Background technique [0002] Skin allergy refers to abnormal phenomena such as skin redness, itching, peeling and allergic dermatitis when the skin is subjected to various stimuli such as adverse reactions of cosmetics, chemical agents, pollen, certain foods, polluted air, etc., in 2014 According to the research results of the Dermatologist Branch of the Chinese Medical Doctor Association on Chinese skin sensitivity, about 20% of men and 30% of women have skin allergies. Mild or early manifestations of skin allergy are dryness, itching, tingling, and redness. In severe cases, it will be red, swollen, and inflamed, and in severe cases, it will fester. [0003] Allergies and irritation have always been a problem for cosmetics. The audience of cosmetics is not selective, and some ...

Claims

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Application Information

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IPC IPC(8): A61K8/97A61Q19/00A61P37/08
CPCA61K8/97A61K2800/805A61Q19/005
Inventor 项光刚周永传陶黎明
Owner 上海承曜生物科技有限公司
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