Amphiphilic guanosine derivatives, preparation method thereof and application in sensing and recognition of cytidine triphosphate

A cytidine triphosphate and amphiphilic technology, which is applied in the preparation of sugar derivatives, sugar derivatives, sugar derivatives, etc., can solve the problems that limit the practical application of chemical sensors, achieve selective recognition, mild reaction conditions, The effect of simple preparation method
CN105384789BInactive Publication Date: 2018-01-12SHAANXI NORMAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHAANXI NORMAL UNIV
Publication Date
2018-01-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention discloses an amphiphilicity guanosine derivative, a preparation method therefor and an application thereof in cytidine triphosphate sensing and recognition. The amphiphilicity guanosine derivative takes a hexadecyl chain as a tail group and a guanosine derivative as a head group, and has the features of biocompatibility and nontoxicity; the amphiphilicity guanosine derivative can be assembled with an amphiphilicity Tb (III) complex to form a vesicle type nano interface; characteristic fluorescence of the Tb (III) complex is greatly sensitized by an energy transfer process between a guanosine construction unit assembled on the interface and the Tb (III) complex; and when cytidine triphosphate which can be in complementary pairing with guanosine is added in the system, the energy transfer process between the guanosine derivative and the Tb (III) complex can be blocked drastically, thereby quenching the characteristic fluorescence of the Tb (III) complex and achieving selective recognition for the cytidine triphosphate. The amphiphilicity guanosine derivative provided by the present invention is simple in preparation method and mild in reaction condition, and can be used for cytidine triphosphate detection.
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Description

technical field

[0001] The invention belongs to the technical field of supramolecular sensing materials, in particular to an amphiphilic guanosine derivative and a preparation method thereof, and a vesicle-type fluorescent supramolecular sensor prepared by using the amphiphilic guanosine derivative in sensing and identifying Application of cytidine triphosphate. Background technique

[0002] Bioanions play an essential role in the normal operation of living organisms, so their identification and detection are of great significance. Phosphate anions and their derivatives are involved in most life processes in living cells. For example: the reversible phosphorylation reaction of protein can be used as a molecular switch to regulate the activity of protein. The phosphorylation process of serine, threonine and tyrosine in protein structure is the basis of protein transmission information; adenosine triphosphate (ATP) is the The energy carrier widely exists in the nucleus, mito...

Claims

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