23 results about "Methoxypropane" patented technology

The present disclosure includes hyperbranched polyether polyols, such as hyperbranched poly(3-(oxiran-2-ylmethoxy) propane-1,2-diol) (HPOD), methods for their preparation and uses thereof, for example, as a cryoprotectant, lyoprotectant or stabilizer.

This invention relates to the field of catalysts, and discloses a gas-phase cracking catalyst, its preparation method, and its application. The catalyst comprises, by weight, 1.5-20 parts of an active component and 80-98.5 parts of a support; the active component is selected from one or more elements of Group IIB, Group IIIA, Group IVA, and Group VA; the active component exists in elemental and / or oxide form; the support is selected from one or more molecular sieves of type ZSM-5, Y-type, and X-type. The catalyst of this invention exhibits high catalytic activity, few byproducts, and high stability in the gas-phase cracking of 2,2-dimethoxypropane to synthesize 2-methoxypropylene, showing promising application prospects.

The invention discloses a preparation method of solar concentrating resin. According to the method, bi-phenolic methane and dimethoxypropane are dissolved in the molar ratio being 1:(8-12), meanwhile, 8-12 ml of a catalyst is added, and the mixture is heated to the temperature of 65-70 DEG C and has a reaction at the temperature for 28-32 min; the mixture is cooled to the temperature of 60 DEG C, a first part of liquid caustic soda is slowly and dropwise added, the mixture is heated, and the reaction temperature is kept to range from 65 DEG C to 70 DEG C, reflux is performed for 2 h, the dimethoxypropane which does not react is recovered in a reduced pressure manner, the mixture is cooled to the temperature below 65 DEG C, 55-65 ml of a solvent is added, meanwhile, a second part of liquid caustic soda is dropwise added, reflux is performed for 2 h, a solvent solution turns yellow and is cooled and washed with hot water, a water layer is separated until the solvent solution is transparent, the solvent is evaporated out, and the resin is prepared. The resin has the characteristics of high concentrating property, high precision, good weather resistance, low cost and the like and can comprehensively improve the efficiency and the quality of a solar concentrating power generation system in the aspects of the optical effect, the weather resistance and the technology.

The invention relates to the technical field of medical and chemical medicines, in particular to a novel synthesis method of L (-)-threo-3-hydroxyaspartic acid hydrochloride. The preparation method comprises the following steps: by taking cheap and easily available D-phenylglycinol as an initial raw material, firstly protecting amino with Boc anhydride, then oxidizing to obtain N-BOC-D-phenylalanine aldehyde 3, then carrying out Grignard reaction on the N-BOC-D-phenylalanine aldehyde 3 and vinyl magnesium bromide at low temperature to obtain corresponding o-amino alcohol, then reacting the o-amino alcohol with 2, 2-dimethoxypropane at 0 DEG C under the catalytic action of p-toluenesulfonic acid, and finally obtaining the 2, 2-dimethoxypropane. The obtained compound 4 is subjected to Upjohn dihydroxylation reaction and sodium periodate oxidation to obtain corresponding aldehyde, and then the aldehyde is oxidized by potassium permanganate under a weak acidic condition to obtain corresponding carboxylic acid 5. Oxidizing a benzene ring by taking ruthenium trichloride as a catalyst and sodium periodate as a co-oxidant to obtain dicarboxylic acid; and finally, refluxing and deprotecting by using hydrochloric acid to obtain the L (-)-chloro-3-hydroxyaspartic acid hydrochloride.

The application provides a light component efficient recovery method, through controlling the rectification separation condition of a Saucy-Marbet reaction liquid, a light component fraction without 2,2-dimethoxypropane or heavier components is obtained, the light component fraction is mixed with a certain amount of a cracking auxiliary, and then is directly introduced into a cracking reactor, 2,2-dimethoxypropane is converted into 2-methoxypropylene and methanol through high-temperature cracking, and then the mixture obtained through cracking is subjected to rectification separation, and the useful component, 2-methoxypropylene, is recycled and utilized. The application simplifies the separation and recycling process of the light component byproduct of the Saucy-Marbet reaction, improves the recycling rate of raw materials, and reduces the operation cost of the project.

Provided are an electrolyte, a battery, and an electric device. The electrolyte comprises an ether solvent and a lithium salt. The ether solvent comprises at least one of 1,2-di((1'-ethoxy)ethoxy)propane, 2,2-diethoxypropane, 2,2-dimethoxypropane, 1,2-dimethoxypropane, 1,3-dimethoxypropane, and 1,2-diethoxyethane. By using an ether solvent having more sterically hindered functional groups, the solvation ability of ether molecules is adjusted by means of the steric hindrance effect, thereby significantly improving the stability of positive and negative electrodes and coulombic efficiency in an ether electrolyte.

This invention provides a method for preparing high-purity catoroxane. The method uses ethylferrocene and dimethoxypropane as reactants, which undergo a condensation reaction in a solvent under the action of an acid catalyst to obtain catoroxane. This invention uses readily available and more reactive 2,2-dimethoxypropane instead of acetone for the condensation reaction to prepare catoroxane. Because 2,2-dimethoxypropane itself has higher reactivity and produces two molecules of methanol after the reaction, the reaction exhibits a larger entropy change, which is more conducive to the forward reaction. Ultimately, the reaction can be carried out under milder conditions with higher conversion and yield of catoroxane. The reaction solution can be simply washed with water and concentrated to complete the product post-processing, without the need for complex impurity removal processes. The purity of the obtained catoroxane can reach over 95%, showing excellent industrialization prospects. In summary, this invention provides a simple and efficient production method for the large-scale preparation of high-purity catoroxane.

This invention relates to the field of nanomedicine formulation technology, and discloses a ROS-responsive astaxanthin nanoparticle, its preparation method, and its application. The preparation method includes: catalyzing the transketalization reaction of 3-mercaptopropionic acid with 2,2-dimethoxypropane using an alcohol-water tolerant Lewis acid catalyst (preferably scandium trifluoromethanesulfonate) to prepare a thioketal monomer containing dual-terminated carboxyl groups; coupling the thioketal monomer with stearyl alcohol and methoxy polyethylene glycol using a stepwise sequential coupling strategy to construct an amphiphilic polymer with thioketal bonds as ROS-responsive connecting units; co-dissolving the polymer, astaxanthin, and tocotrienols in tetrahydrofuran, and preparing the nanoparticles using a multi-inlet micro-collision flow nanoprecipitation process. The resulting nanoparticles have a particle size of 100 nm to 200 nm, an astaxanthin encapsulation rate of 90% to 99%, and achieve targeted release in response to reactive oxygen species in the pathological microenvironment. Astaxanthin and tocotrienols synergistically exert antioxidant effects.

This invention belongs to the field of Chlorella application technology, specifically relating to a method for extracting nanocellulose from Chlorella, comprising the following steps: S1, defatting dried Chlorella powder using the methanol-chloroform method; S2, adding anhydrous acetone to the defatted Chlorella powder, then adding 2,2-dimethoxypropane and p-toluenesulfonic acid to react, and centrifuging to collect the precipitate after the reaction, obtaining protected Chlorella cellulose; S3, deproteinizing with an alkali method; S4, adding an acetic acid aqueous solution to the deproteinized protected cellulose, centrifuging to collect the precipitate after the reaction, washing the precipitate to neutral and then dialyzing to obtain deprotected Chlorella cellulose; S5, bleaching and purification; S6, preparing Chlorella nanocellulose. This invention, by adding 2,2-dimethoxypropane to defatted Chlorella powder, forms a stable protecting group, preventing cellulose degradation under strong alkali, thereby reducing the breakage and loss of cellulose molecular chains.

The invention relates to the technical field of chemical separation, and discloses a method for recovering light components in a rearrangement reaction and a reaction recovery system.The method comprises the steps that S1, unsaturated alcohol, 2-methoxypropene and a catalyst are mixed to be subjected to the rearrangement reaction, and a reaction solution with the acid value being 0.01-0.5 mgKOH / g is obtained; the catalyst comprises one or more of inorganic acid, aromatic sulfonic acid, aliphatic sulfonic acid and fatty acid; and S2, carrying out rectification treatment on the reaction liquid at the temperature of 110-160 DEG C and the pressure of 30-80 kPa, and recovering the 2-methoxypropene from the tower top liquid after rectification. According to the rearrangement reaction system, the acid value of the reaction liquid is adjusted to be 0.01-0.5 mg KOH / g, the rectification temperature and pressure conditions are combined, 2, 2-dimethoxypropane can be cracked in the rectification tower to generate 2-methoxypropene and methanol, tower top liquid obtained after rectification is washed with water and then separated to obtain high-purity 2-methoxypropene, and efficient closed-loop recycling of light components is achieved.

The application belongs to the technical field of synthesis of medical intermediates, and particularly relates to a synthesis method of a chiral intermediate of atorvastatin calcium. 1,3-propanediol is used as raw material, a silicon-based protection reaction is carried out, and then oxidation is carried out, a ring addition reaction occurs under the catalysis of a chiral catalyst and a lithium salt, and a first chiral center is introduced; then, t-butyl acetate is added to carry out a ring opening reaction, a Narasaka-Prasad reduction reaction is carried out to induce a second chiral center; 2,2-dimethoxypropane is added to protect cis diol, finally, tetrabutylammonium fluoride is added to remove the silicon-based reaction, and a Fukuyama amine synthesis method is used to replace the hydroxyl group with the amino group to obtain the chiral intermediate of atorvastatin calcium. The application uses 1,3-propanediol which is cheap and easy to obtain as raw material, and various dangerous, toxic and expensive drugs are not used in the synthesis route process, the method has a simple route, high yield and good repeatability, and can be used for industrial production.

The present invention relates to a process for the preparation of 2-isopentyl-2- isopropyl-1,3-dimethoxypropane, said process comprising the steps of: i) contacting iso-valeraldehyde with an aqueous solution of a hydroxide base selected from the group consisting of sodium hydroxide (NaOH), potassium hydroxide (KOH) or a combination thereof, said solution having an amount of said hydroxide base of at least 20% w / v, and (m) ethanol; form (2Z)-2-isopropyl-5-methyl-2-hexenal; step ii) contacting (2Z)-2-iso-propyl-5-methyl-2-hexenal with a reducing system to form 2-isopropyl-5-methylhexanal; step iii) contacting 2-isopropyl-5-methylhexanal with formaldehyde and an inorganic base to form 2-isopentyl-2-isopropylpropane-1,3-diol; and step iv) contacting 2-isopentyl-2-isopropylpropane-1,3-diol with a methylation agent and a base to form 2-isopentyl-2-isopropyl-1,3-dimethoxypropane.

This invention discloses a low-temperature curable PI photoresist suitable for flexible substrates and its preparation method, belonging to the field of semiconductor electronic chemicals and flexible display manufacturing technology. The method involves dissolving an allyl-containing soluble polyimide resin in 2-acetoxy-1-methoxypropane, adding a mercapto-containing photocrosslinking component, a photoinitiator, and a heteroaryl base-type low-temperature curing accelerator to obtain a coating solution. This coating solution is then applied to a flexible substrate, followed by pre-baking, UV exposure, development, and rinsing, and post-curing at 180°C to 230°C to obtain a patterned polyimide film. This invention utilizes a soluble resin combined with a mercapto-olefin crosslinking system and a curing accelerator, avoiding the high-temperature closed-loop requirement of traditional PI precursors. This not only achieves low-temperature curing characteristics and reduces the risk of thermal damage to flexible substrates but also significantly improves the film's bending resistance and strain adaptability.

The invention relates to the technical field of polypeptide drugs, and particularly discloses a synthetic method of pseudo-proline dipeptide. The method comprises the following steps: by taking amino-protected Fmoc-Xaa-OH and serine methyl ester hydrochloride or threonine methyl ester hydrochloride as raw materials, firstly carrying out amino acid condensation, then carrying out acid catalysis with 2, 2-dimethoxypropane to obtain a cyclized intermediate, and finally hydrolyzing in the presence of an organic tin alkali reagent to generate the target compound pseudo-proline dipeptide. The method has the advantages of mild conditions, high selectivity, high conversion rate, few by-products, almost complete avoidance of racemization, perfect reservation of the acid-sensitive oxazolidine ring, no influence on other common protecting groups such as Fmoc, Boc and Trt, high selectivity, no influence on other more stable esters such as tert-butyl ester and benzyl ester, and good substrate adaptability.

The application provides an electrolyte and a lithium metal battery, and relates to the technical field of lithium metal batteries.The electrolyte comprises a lithium salt and an ether solvent; the lithium salt comprises a sulfoximine lithium salt and a fluoroboric acid lithium salt in a molar ratio of 1: (0.1-0.5); the ether solvent comprises a linear ether solvent and a chlorinated linear ether solvent; the linear ether solvent comprises at least one of 1,2-dimethoxypropane, 1,3-dimethoxypropane, 1,2-diethoxyethane and 1-methoxy-2-ethoxyethane; and the chlorinated linear ether solvent is a compound with formula (I): (I); wherein R1 is selected from C1-C4 chlorinated alkyl, and R2 is selected from C1-C4 alkyl and C1-C4 chlorinated alkyl. The application solves the problem that the interface stability of the electrolyte in the prior art lithium metal battery is insufficient, and the capacity retention rate in a long-period cycle process is poor and the coulombic efficiency of a lithium-copper half battery is low.

The application provides a synthesis method of 2-methoxypropene, which comprises the following steps: step A: performing reverse contact reaction of ethylene glycol and acetone in the presence of a first catalyst and an extractant to generate acetone acetal, separating acetone acetal-containing extract liquid and performing rectification to obtain acetone acetal; step B: contacting the acetone acetal with methanol in the presence of a second catalyst, heating to 100-150 DEG C, increasing the gauge pressure to 0.40-1.50 MPa, performing pressurized reaction rectification to generate 2-methoxypropene, and separating 2-methoxypropene as a target product; the method can reduce the reaction energy barrier, promote the synthesis of 2-methoxypropene under mild reaction conditions, is environment-friendly, low in energy consumption, low in by-product impurities, low in raw material and auxiliary material cost, simple in post-treatment and suitable for continuous industrial production; the pressurized reaction rectification is adopted to directly synthesize 2-methoxypropene from acetone acetal, and the process of synthesizing 2,2-dimethoxypropane and cracking to prepare 2-methoxypropene is reduced.

The invention provides an ether high-entropy electrolyte adaptive to a silicon-based negative electrode of a lithium ion battery, the ether high-entropy electrolyte comprises a lithium salt, a solvent and an inert diluent, and the solvent is ethylene glycol dimethyl ether, ethylene glycol diethyl ether, diethylene glycol dimethyl ether, dipropyl ether, triethylene glycol dimethyl ether, tetraethylene glycol dimethyl ether and 1, 2-propylene glycol dimethyl ether. The solvent is at least three of 1, 3-dimethoxypropane or the solvent is at least three of tetrahydrofuran, 2-methyltetrahydrofuran, tetrahydropyrane and 1, 3-dioxolane; the inert diluent is selected from at least one of 1, 1, 2, 2-tetrafluoroethyl-2, 2, 2-trifluoroethyl ether, bis (2, 2, 2-trifluoroethyl) ether and 1, 1, 2, 2-tetrafluoroethyl-2, 2, 3, 3-tetrafluoropropyl ether, and the inert diluent is selected from at least one of 1, 1, 2, 2-tetrafluoroethyl-2, 2, 2-trifluoroethyl ether, bis (2, 2, 2-trifluoroethyl) ether and 1, 1, 2, 2-tetrafluoroethyl-2, 2, 3, 3-tetrafluoropropyl ether; the solvents are chain ether or cyclic ether, the diluents are of similar structures, the minimum enthalpy increase and the maximum entropy increase of the electrolyte system are achieved at the same time, and the Gibbs free energy of the electrolyte system is reduced. According to the invention, stable construction of the high-entropy electrolyte is realized, and the problem of insufficient ionic conductance caused by weak solvation characteristics of ether electrolytes is effectively solved.

The invention discloses a preparation method for large-scale efficient synthesis of 1, 3-dimethoxypropane, and relates to synthesis of a diether compound in the field of organic synthesis. Step 2, obtaining a mixed product of the 1, 3-dimethoxypropane containing the sodium hydride; step 3, obtaining a 1, 3-dimethoxypropane product which does not contain sodium hydride; step 4, obtaining a 1, 3-dimethoxypropane solution; 5, after dehydration, carrying out reduced pressure distillation to obtain 1, 3-dimethoxypropane; according to the invention, 1, 3-dihalogenated propane reacts with sodium methoxide under the action of sodium hydride (NaH), so that 1, 3-dimethoxypropane is obtained with high yield.

The invention relates to an electrochemical cell comprising: —at least one anode comprising metallic lithium or a lithium alloy or at least one anode comprising a current collector at least partially covered with metallic lithium deposited after at least one charge of the cell, the cell not containing metallic lithium at the time of its manufacture, —at least one cathode, —a liquid or gelled electrolyte composition comprising: a) a solvent comprising: i) either a mixture of 1,1,1,3,3,3-hexafluoro-2-methoxypropane (HFMP) and / or 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)propane (HFMFP), ethylene monofluorocarbonate (F1EC) and 2,2,2-trifluoroethyl methyl carbonate (F3EMC), ii) or a mixture of 1,1,1,3,3,3-hexafluoro-2-methoxypropane (HFMP) and / or 1,1,1,3,3,3-hexafluo-ro-2-(fluoromethoxy)propane (HFMFP), ethylene monofluorocarbonate (F1EC) and 2,2,2-trifluoroethyl acetate (F3EA), b) at least one salt whose cation is the lithium cation, c) lithium difluorophosphate LiPO2F2 in an amount representing from 0.05 to 5% of the mass of the combination made up of the solvent and said at least one dissolved lithium salt.

To provide a fluorinated dialkyl carbonate and a sulfite compound useful for a battery, and to provide a method for producing the same.SOLUTION: The use of fluorinated ethers such as 1,1,1,3,3,3,3, - hexafluoro-2-methoxypropane (HFMOP) as a reaction solvent for preparing fluorinated dialkyl carbonate and sulfite compounds, and battery electrolytes comprising fluorinated dialkyl carbonate and sulfite compounds and low levels of fluorinated ethers such as HFMOP for use in batteries comprising high Ni cathodes and silicon-containing anodes.SELECTED DRAWING: Figure 1

The invention relates to the technical field of medical chemical medicines, in particular to a novel synthesis method of cis-chiral alpha-hydroxy-beta-amino acid hydrochloride. The preparation method comprises the following steps: taking cheap and easily available natural alpha-amino acid as a starting raw material, firstly, preparing N-Boc protected amino aldehyde 2 from the natural alpha-amino acid as the starting raw material, then carrying out Grignard reaction on the N-Boc protected amino aldehyde 2 and vinyl magnesium bromide at low temperature to obtain corresponding o-amino alcohol, then reacting the o-amino alcohol with 2, 2-dimethoxypropane at 0 DEG C under the catalytic action of p-toluenesulfonic acid, and finally obtaining the N-Boc protected amino aldehyde 2. And performing stereospecific ring closing to obtain trans-oxazolidine 3. The compound 3 is subjected to Upjohn dihydroxylation reaction and sodium periodate oxidation to obtain corresponding aldehyde, and then the aldehyde is oxidized by potassium permanganate under a weak acidic condition to obtain corresponding carboxylic acid 4. And finally, carrying out reflux deprotection by using 6N hydrochloric acid to obtain the cis-chiral alpha-hydroxyl-beta-amino acid hydrochloride. The synthetic route is convenient to operate, the total yield is high, and large-scale preparation can be achieved.

The present application relates to a kind of chiral alpha-amino alcohol compounds and its preparation method and application, utilize Boc-L-serine methyl ester as chiral source, utilize 2,2-dimethoxypropane ring closure protection amino and hydroxyl, by simple and easy primary grignard reagent and Boc-L-serine methyl ester occur nucleophilic reaction generation hydroxyl, then alcohol hydroxyl can be eliminated into double bond under the participation of burgess reagent, finally palladium-carbon hydrogen gas reduction double bond obtains alpha-amino alcohol precursor, amino alcohol precursor is deprotected under acidic condition and can obtain N-alpha-C by secondary alkyl chain modification alpha-amino alcohol.The method compared with traditional method, with shorter time consumption, higher total yield and so on.The method is expected to be widely used in the synthesis of nitrogen-containing chiral ligand in the field of asymmetric synthesis.