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Application of xylaria nigripe extract in skin whitening and moisturizing cosmetic

A technology of C. nigritiformis and its extract, which is applied in the direction of cosmetics, cosmetic preparations, dressing preparations, etc., to achieve the effects of inhibiting activity, improving economic use value, and broadening the application field

Active Publication Date: 2016-03-23
GUANGZHOU GIALEN COSMETICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the research of C. nigriscens has shown that it has anti-free radical, anti-oxidation and anti-aging effects, and its applications are mostly concentrated in industries such as pharmaceuticals, food, and health products. In cosmetics, its extracts have moisturizing and whitening properties. The active efficacy has not been reported

Method used

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  • Application of xylaria nigripe extract in skin whitening and moisturizing cosmetic
  • Application of xylaria nigripe extract in skin whitening and moisturizing cosmetic
  • Application of xylaria nigripe extract in skin whitening and moisturizing cosmetic

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Rinse the sclerotia of C. nigritiformis with sterile water, then sterilize the surface with 75% alcohol by volume, cut into pieces of about 2mm×2mm size on the ultra-clean table, and inoculate them into the improved PDA slant medium (in Add 0.45% of yeast extract and 0.5% of potassium dihydrogen phosphate to the PDA basic medium, and then enter the fermenter for fermentation after conventional cultivation at 25°C to 30°C, and the inoculum size is 10% by volume The fermentation time is about 2-3 days, the fermentation process parameters are pH value 5.0-7.0, stirring speed 120-250rpm, ventilation volume 1-4VVM, fermentation temperature 25℃-30℃, tank pressure 0.03-0.05MPa, The fermentation medium consists of 90g of glucose, 3g of ammonium sulfate, 1g of dipotassium hydrogen phosphate trihydrate, 4g of glutamic acid, 2g of triammonium citrate, 5mg of ferrous sulfate heptahydrate, and 4mg of zinc sulfate per liter, and the pH is adjusted to 5-5.5. After the fermentation is ...

Embodiment 2

[0039] Appropriate amount of mycelia of C. nigritiformis (prepared in Example 1) was pulverized, passed through a 80-mesh sieve, added drinking water equivalent to 30 times the quality of the mycelium, heated to 80°C, and used ultrasonic waves (power of 120W) at this temperature Extract for 90 minutes, filter to obtain the filtrate, concentrate to a density of 1.02, and obtain the extract of C. nigritiformis.

Embodiment 3

[0041] Appropriate amount of Sclerotia sclerotiorum was crushed, passed through 80 mesh sieve, added drinking water equivalent to 20 times the quality of sclerotia, heated to 80°C, extracted with ultrasonic wave (power 120W) for 90 minutes at this temperature, and filtered to obtain The filtrate is concentrated to an appropriate amount, left to cool, slowly adding 95% ethanol by volume in a stirring state, so that the ethanol concentration in the finally obtained mixed solution is 65% by volume, sealed for 12 hours, and the precipitation is complete, and the supernatant is taken, The ethanol was recovered under reduced pressure, concentrated, and then filtered through a 0.45 μm microporous membrane to obtain the extract of C. nigritiformis.

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Abstract

The invention discloses application of a xylaria nigripe extract in a skin whitening and moisturizing cosmetic. The inventor finds that the xylaria nigripe extract has the better moisturizing effect, can effectively inhibit the activity of in-vitro tyrosinase and has the effect of skin whitening for the first time. According to the application of the xylaria nigripe extract in the skin whitening and moisturizing cosmetic, the application field of xylaria nigripe is broadened, and the economic using value of xylaria nigripe is improved.

Description

technical field [0001] The invention belongs to the field of cosmetics, and in particular relates to the application of an extract of C. nigriscens in whitening and moisturizing cosmetics. Background technique [0002] Xylaria nigripes (Kl.) Sacc. is a fungus of the genus Xylariasp. (also known as Xylariasp.) . It is distributed in temperate, subtropical, and tropical regions, so it has many aliases such as Wulingshen, Chicken Poria, and Ditan stick. Lei Zhenzi and others. It is sweet and flat in nature, non-toxic, and is usually found growing in dead or decaying termite nests. When the mycelium of C. nigritiformis grows to a certain period, part of the dense knots form mycelium, protruding from the ground to form sub-seats, part of the mycelium densely forms sclerotia, and gradually breaks away from the mycelium, hanging in the underground termite nest cavity or On the fungus garden. Mycelia, fungal cords, and sclerotia all have the effects of invigorating qi and stren...

Claims

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Application Information

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IPC IPC(8): A61K8/97A61Q19/02A61Q19/00
CPCA61K2800/782A61K2800/85A61Q19/00A61Q19/02
Inventor 蔡丙国傅国华刘少勇
Owner GUANGZHOU GIALEN COSMETICS
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