Application of Racemulsonine in preparing medicine for resisting human body fungi

An antifungal and drug technology, applied in the direction of antifungal agents, can solve the problems of irritation, dizziness, allergy, strong accumulation of toxicity, etc., and achieve the effect of outstanding substantive characteristics and strong inhibitory activity

Inactive Publication Date: 2016-03-23
ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The spread of pathogenic bacteria and the enhancement of drug resistance seriously threaten human health and life. Antibacterial drugs have been widely used as routine drugs in the treatment of AIDS, organ transplantation and chronic wasting diseases (such as cancer, diabetes, uremia, etc.) Treatment, although the antibacterial agents currently used clinically have good curative effect on skin and superficial infection, but these antibacterial agents have strong cumulative toxicity and often cause liver and kidney damage, digestive tract irritation, dizziness, allergies, etc. New antibacterial drugs with unique mechanisms have become one of the hot spots in drug research and development today

Method used

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  • Application of Racemulsonine in preparing medicine for resisting human body fungi
  • Application of Racemulsonine in preparing medicine for resisting human body fungi
  • Application of Racemulsonine in preparing medicine for resisting human body fungi

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Embodiment 1: the preparation of compound Racemulsonine tablet involved in the present invention:

[0011] Take 5 grams of the compound Racemulsonine, add 195 grams of dextrin, mix well, and make 1000 tablets by conventional compression.

Embodiment 2

[0012] Embodiment 2: the preparation of compound Racemulsonine capsules involved in the present invention:

[0013] Take 5 grams of the compound Racemulsonine, add 195 grams of starch, mix well, and make 1000 capsules.

[0014] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0015] Experimental example 1: Racemulsonine anti-fungal activity in humans

[0016] The anti-fungal activity experiment against human body adopts the method of concentration dilution, and each determination is repeated three times. The test pathogens include Trichomonas rubrum, Microsporum lanoides and Trichomonas clumps, and the concentration of bacteria solution is 105 / mL. The initial concentration of Racemulsonine is 50.0 μg / mL (5% dimethyl sulfoxide DMSO), serially diluted to 0.098 μg / mL, and the equal volume of bacterial liquid and test samples are mixed and cultured in a 96-well plate, and the culture temperature of human fungi is respectively 28°C, observe after 24 hours of incubation time, if no colonies are found, it is the lowest anti-human fungal concentration of the sample, that is, the MIC value. The positive control of this experiment is ketoconazole, and the results of Racemulsonine against human fungi are shown in Table 1.

[0017] Table 1 Racemulsonine anti-...

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PUM

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Abstract

The invention relates to application of Racemulsonine in preparing medicine for resisting human body fungi, and belongs to the field of medicine. Racemulsonine has the strong effect of inhibiting trichophyton rubrum or microsporum lanosum or trichophyton tonsurans, and thus Racemulsonine can serve as a compound for resisting human body fungi and is expected to be applied to preparing related medicine. The application is disclosed for the first time, Racemulsonine is in a bran-new skeleton type and has strong inhibitory activity on human body fungi, and thus Racemulsonine has outstanding substantive features. Meanwhile, Racemulsonine has remarkable progressiveness when used for preventing and treating human body fungus infection.

Description

technical field [0001] The present invention relates to a new application of compound racemulsonine, in particular to the application of racemulsonine in the preparation of antifungal drugs for human body. Background technique [0002] The spread of pathogenic bacteria and the enhancement of drug resistance seriously threaten human health and life. Antibacterial drugs have been widely used as routine drugs in the treatment of AIDS, organ transplantation and chronic wasting diseases (such as cancer, diabetes, uremia, etc.) Treatment, although the antibacterial agents currently used clinically have good curative effect on skin and superficial infection, but these antibacterial agents have strong cumulative toxicity and often cause liver and kidney damage, digestive tract irritation, dizziness, allergies, etc. New antibacterial drugs with unique mechanisms have become one of the hot spots in drug development today. [0003] The compound Racemulsonine that the present invention...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/439A61P31/10
CPCA61K31/439
Inventor 田丽华
Owner ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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