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Angiogenesis inhibitor polypeptide HS-1 and application thereof

An angiogenesis inhibition, HS-1 technology, applied in the field of bioengineering, can solve the problems of patients' quality of life hazards, unsatisfactory curative effect, damage to normal tissues and organs, etc., achieve high-efficiency tumor targeting ability, inhibit tumor growth process and improve Effect

Inactive Publication Date: 2016-03-23
李斯文
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] At present, cancer has become another killer besides cardiovascular disease. The main treatment methods for cancer are surgery, chemotherapy and radiotherapy. However, most of the chemotherapy drugs are not selective and are widely distributed in various organs in the body. The dose will cause great damage to normal tissues and organs. Although the patient's condition can be temporarily relieved, it will seriously harm the patient's quality of life, and the curative effect is not very satisfactory.

Method used

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  • Angiogenesis inhibitor polypeptide HS-1 and application thereof
  • Angiogenesis inhibitor polypeptide HS-1 and application thereof
  • Angiogenesis inhibitor polypeptide HS-1 and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0024] (1) The synthesis of HS-1 peptide comprises the following steps:

[0025] 1) Coupling: first swell Fmoc-ASP-RinkamideMBHAresin (fluorenyl methaneoxycarbonyl-aspartic acid-rink amino resin) 0.33 / 2mmol6.06g in DMF, 10ml / g resin, then use 20%piperdine / DMF The solution removes the Fmoc protecting group (hereinafter referred to as decapping), washes the resin after decapping with DMF, adds raw material Fmoc-Arg(tBU)-OH2.3g, and uses HBTU1.44g as the condensing agent. The reaction time is 30 minutes, and the Kaiser method detects , if the test result is negative, it means that the coupling reaction is complete, then proceed to uncap for 30 minutes, if the test result is still positive, it means that the coupling reaction is not completed or the reaction is incomplete, and it is necessary to extend the coupling time or re-feed Coupling until the coupling reaction is complete.

[0026] Repeat the above operation, and sequentially couple Fmoc-Gly(OtBU)-OH,...FmocGly--OH; Fmoc-P...

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Abstract

The invention provides an angiogenesis inhibitor polypeptide HS-1. The polypeptide is composed of nineteen amino acids, wherein the sequence of the polypeptide is Ser-Ile-Val-Arg-Arg-Ala-Asp-Arg-Ala-Ala-Val-Pro-Gly-Gly-Gly-Gly-Gly-Arg-Asp, and the polypeptide HS-1 has tumor specific selectivity. In addition, the invention provides application of the polypeptide HS-1 in tumor diagnosis, prevention and treatment. The polypeptide HS-1 has the advantages of targeting performance and high anti-tumor activity.

Description

technical field [0001] The invention belongs to the technical field of bioengineering, and in particular relates to an angiogenesis inhibitor polypeptide HS-1 and its application. Background technique [0002] At present, cancer has become another killer besides cardiovascular disease. The main treatment methods for cancer are surgery, chemotherapy and radiotherapy. However, most of the chemotherapy drugs are not selective and are widely distributed in various organs in the body. The dose will cause great damage to normal tissues and organs. Although the patient's condition can be temporarily relieved, it will seriously harm the quality of life of the patient, and the curative effect is not very satisfactory. Therefore, the development of chemotherapeutic drugs with tumor-specific selectivity has become a research hotspot. [0003] Integrin receptor (Integrin) is one of the important members of the cell adhesion molecule family, which mainly mediates the interaction between...

Claims

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Application Information

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IPC IPC(8): C07K7/08C07K1/36C07K1/30C07K1/16C07K1/06G01N33/68A61K38/10A61P35/00
CPCC07K7/08A61K38/00G01N33/6893G01N2800/7028
Inventor 李斯文赵磊
Owner 李斯文