High-targeting nano drug carrier constructed on basis of hydroxyl guide and preparation method of high-targeting anti-tumor drug

Abstract

The invention belongs to the field of nano drugs and biomedicines and in particular relates to a high-targeting nano drug carrier constructed on basis of hydroxyl guide and a preparation method of a high-targeting anti-tumor drug. The invention provides a new tumor targeting positioning way; a functional group carried by the drug carrier has an acidophilic property, so that a tumor acidic environment is positioned. Under the condition that a targeting biological recognition molecule is not introduced and the production cost of the nano drugs is reduced, the size and structure of the nano carrier are kept better, so that a targeting positioning capability of a nano enrichment effect on tumor cells is effectively kept, and furthermore, the targeting performance of a constructed nano drug carrying system is improved. The constructed nano anti-tumor drug has an efficient tumor targeting capability and has an excellent pH (Potential of Hydrogen) controlled release effect and a long-period slow release capability; the tumor cells can be efficiently killed and damages to normal cells are very small.

Description

technical field [0001] The invention belongs to the field of nano-medicine and biomedicine, and in particular relates to a preparation method of a highly targeted nano-medicine carrier and an anti-tumor drug based on hydroxyl-guided construction. Background technique [0002] Chemotherapy (chemotherapy) is one of the most effective methods for clinical treatment of cancer, and it is also called the three major means of cancer treatment together with surgery and radiotherapy. Unlike surgery and radiotherapy, which are only effective for the tumor at the treatment site, chemotherapy is a systemic treatment, and chemical drugs will spread throughout the body with the blood circulation. Therefore, for some tumors with a tendency to metastasize and advanced tumors that have already metastasized, chemotherapy is a main treatment. However, the anti-tumor effect of current chemotherapy needs to be further improved. This is mainly because traditional chemotherapy drugs are not targe...

AI Technical Summary

Problems solved by technology

However, due to the introduction of expensive antibodies, receptors or immune molecules, and the complex and difficult-to-control reaction process of this approach, the final drug is expensive, far beyond the economic affordability of ordinary patients

At the same time, due to the introduction of additional components, the size and shape of nano-drugs are greatly affected, which is not conducive to nano-drugs penetrating the cell membrane and entering tumor cells, and will also lead to a great suppression of the nano-enrichment effect.

In addition, due to the specificity of different tumor targets, these labeling methods lack effective targeting methods for new tumors formed after systemic metastasis of tumor cells.

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