Chicken growth performance breeding molecular marker GHR (growth hormone receptor) gene and application thereof

A technology of molecular markers and growth performance, applied in the field of genetic engineering of animal molecular breeding, can solve problems such as growth retardation, lack of effective combination of GH and GHR, slow growth, etc.

Inactive Publication Date: 2016-03-30
YUNNAN AGRICULTURAL UNIVERSITY
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Problems solved by technology

[0004] In the study of the GHR gene, human LTD dwarfism and sex-linked dwarf chickens are two well-studied examples of slow growth and short stature caused by GHR gene mutations. The liver lacks effective GHR, or GHR gene mutations, The effective combination of GH and GHR is deficient, leading to the interruption of the growth axis pathway, and finally leads to the low level of IGF-1. Even if the plasma GH concentration is significantly higher than that of normal chickens, the growth is still hindered, so the body size of SLD chickens is significantly lower than that of normal chickens individual

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  • Chicken growth performance breeding molecular marker GHR (growth hormone receptor) gene and application thereof
  • Chicken growth performance breeding molecular marker GHR (growth hormone receptor) gene and application thereof
  • Chicken growth performance breeding molecular marker GHR (growth hormone receptor) gene and application thereof

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Embodiment Construction

[0021] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the embodiments of the present invention and the accompanying drawings. Obviously, the described embodiments are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0022] 1. Determination of body weight traits

[0023] In this experiment, 100 20-week-old Daweishan miniature chickens and 100 Wuding chickens, half male and half female, were used for body weight measurement. The body weight of 20-week-old Wuding chickens was significantly higher than that of Daweishan miniature chickens.

[0024] Table 1 Comparative analysis of body weight and body size traits of different breeds of chickens

[0025]

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Abstract

The invention relates to the gene engineering technology for molecular breeding of animals, in particular to a chicken growth performance breeding molecular marker GHR (growth hormone receptor) gene and an application technology thereof. Wuding chickens and Daweishan mini-chickens specific to the Yunnan Province are used as research materials, an SNP (single nucleotide polymorphism) site related to the growth performance of the Daweishan mini-chickens and the Wuding chickens is screened out and identified with a target area deep re-sequencing method in combination with bioinformatics analysis, molecular marking is performed, a 571A / G mutation site (the 75630 site of the GHR gene) significantly related to the weight is screened out of an intron 5 of the GHR gene and used as a molecular marker for assisted selection for chicken breeding, and the important science reference is provided for breeding of local chickens in the Yunnan Province.

Description

technical field [0001] The invention relates to the genetic engineering technology of animal molecular breeding, in particular to a chicken growth performance selective breeding molecular marker GHR gene and its application technology. Background technique [0002] Growth hormone receptor (GHR) is located on the GH-GHR-IGF axis, and regulates the expression of IGFs by mediating growth hormone (GH), thus playing an important role in regulating growth and development in vivo. The combination of GH and GHR can regulate animal growth. It has the functions of regulating nutrient distribution, promoting protein synthesis, reducing fat deposition, promoting skeletal muscle growth, increasing animal growth speed and feed remuneration, and participating in animal immunity, reproduction, lactation and other physiological functions and metabolism. adjustment. [0003] GHR is necessary for normal development of animals. GH plays an important role in promoting metabolic processes such ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68C12N15/11
CPCC12Q1/6888C12Q2600/124C12Q2600/156
Inventor 荣华曹振辉刘丽仙贾俊静豆腾飞汪善荣赵筱张彦华李琦华李正田徐志强谷大海林秋叶佟荟全葛长荣
Owner YUNNAN AGRICULTURAL UNIVERSITY
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