In-vitro determination test method for thrombolytic drug individual application dosage
A thrombolytic drug and in vitro measurement technology, applied in the field of clinical medicine, can solve the problems of affecting the effect of thrombolytic therapy, application limitations, fatal bleeding complications of thrombolytic drugs, etc.
Inactive Publication Date: 2016-04-06
KAILUAN GENERAL HOSPITAL
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Problems solved by technology
Thrombolytic therapy is currently the most promising treatment for ischemic cardiovascular and cerebrovascular diseases, but it has the characteristics that excessive doses of thrombolytic drugs can lead to fatal bleeding complications, while too small doses will affect the effect of thrombolytic therapy. , so its application is greatly limited, so it is necessary to solve the problem of safe and effective individualized dosage of thrombolytic drugs for each specific patient at different times from the aspect of technical methods
Method used
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Experimental program
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Embodiment Construction
[0017] The present invention will be further described below in conjunction with embodiments, but this embodiment does not constitute any limitation on the present invention.
[0018] The test method for in vitro determination of the individual applied dose of thrombolytic drugs described in this embodiment is carried out according to the following steps:
[0019] (1) Equipment preparation:
[0020] Blood mixer, electronic balance, vortex mixer, pipette, etc.
[0021] (2) Experimental supplies:
[0022] Urokinase for injection, r-TPA, 0.9% saline, Chancler rotating ring, blood collection device, filter paper, EP tube, etc.
[0023] (3) Experimental preparation:
[0024] (1) Preparation of the experimental instrument: turn on the blood mixer to warm up for 20 minutes to 37 degrees for standby, and adjust the electronic balance to level calibration for standby;
[0025] (2) Preparation of thrombolytic drugs: Take 100,000 units of urokinase for injection or 20 mg of r-TPA, divide them into 20...
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The invention relates to an in-vitro determination test method for thrombolytic drug individual application dosage. The method is characterized by comprising the steps that venous blood of an inspected patient is drawn and added into eight rotary rings, wherein the first rotary ring is empty, the second rotary ring contains normal saline and the third to eighth rotary rings contain thrombolysis drug reagents with the concentration from low to high; the eight rotary rings are placed into a blood mixing instrument, and the mixing instrument is started; the rotary rings are taken out of the mixing instrument, formed thrombi and residual blood in the rotary rings are taken out to be placed on the surface of filter paper, the form, volume and weight of the thrombi taken out of the eight rotary rings are observed in sequence, and the formed thrombus with the maximum volume and weight or the concentration of thrombolytic drug which exits correspondingly when no thrombus is formed are recorded; according to the formula, the intravenous thrombolytic drug dosage at the time is equal to 2 / 3*the body weight*thrombolytic drug concentration, and the dosage of the inspected patient is calculated. According to the in-vitro determination test method, the effective thrombolysis of the inspected patient can be determined, bleeding and other complications can be avoided, and therefore intravenous thrombolysis treatment on patients with acute heart and cerebral infarction is guided.
Description
Technical field [0001] The invention relates to an in vitro test method for the individualized applied dose of thrombolytic drugs, which is used to guide the acute arterial infarction in brain, heart and other parts, suitable for intravenous thrombolytic therapy with thrombolytic drugs such as urokinase and r-TPA. It belongs to the field of clinical medicine technology. Background technique [0002] The morbidity, disability and mortality of acute thrombotic diseases in the heart, cerebrovascular and other parts of human beings have risen sharply. It has become the first cause of human death and has a trend of youthfulness, which has seriously threatened humanity. Health. Therefore, it is urgent to improve the prevention and treatment of thrombotic diseases and reduce the cost of treatment, and it has attracted worldwide attention. Thrombolytic therapy is currently the most promising treatment method for ischemic cardiovascular and cerebrovascular diseases, but because it has t...
Claims
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IPC IPC(8): G01N33/48
CPCG01N33/48G01N2800/2871
Inventor 元小冬
Owner KAILUAN GENERAL HOSPITAL