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A kind of glucose-free electrolyte injection and preparation method thereof

A technology of electrolyte injection and glucose, which is applied in the field of electrolyte injection, can solve the problems of exacerbation and aggravation of metabolic acidosis, and achieve the effects of restoring buffering effect, fast metabolism, and scientific and reasonable prescription

Active Publication Date: 2019-01-08
CHANGSHA LIXING MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The purpose of the present invention is to provide a brand-new electrolyte injection to replace the existing electrolyte injection, so as to solve the problem of changing from one electrolyte imbalance to another electrolyte imbalance due to insufficiency or improper concentration of elements required for supplementing physiology. ;Prevent the aggravation of metabolic acidosis due to the low pH value of the medicinal solution or the improper use of acid-correcting drugs; avoid the serious adverse reactions induced by the use of glucose to aggravate the existing hyperglycemia symptoms

Method used

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  • A kind of glucose-free electrolyte injection and preparation method thereof
  • A kind of glucose-free electrolyte injection and preparation method thereof
  • A kind of glucose-free electrolyte injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1: prepare 20 bottles, every bottle 500ml:

[0035] Sodium chloride

57.3g

potassium chloride

3g

Magnesium Chloride (MgCl 2 ·6H 2 O)

3g

Calcium Chloride (CaCl 2 2H 2 O)

3.7g

Sodium acetate (C 2 h 3 NaO 2 ·3H 2 O)

34 g

Sodium citrate (C 6 h 5 Na 3 o 7 2H 2 O)

18.6g

Zinc sulfate (ZnSO 4 ·7H 2 O)

46 mg

Water for Injection

Add to 10L

[0036] Preparation:

[0037] 1. Take 10L water for injection at about 100°C, first add calcium chloride to stir the solution to clarify, then weigh in other ingredients in the prescribed amount in turn, stir to dissolve, add 0.1% activated carbon for needles, stir for 15 minutes, filter with 0.45μm membrane Filter to decarb.

[0038] 2. Add water for injection to the filtrate to make the volume of the liquid medicine 10L, and stir well.

[0039] 3. Fine filtration of liquid medicine with 0.22μm filter membrane.

...

Embodiment 2

[0045] Embodiment 2: prepare 20 bottles, every bottle 500ml:

[0046] Sodium chloride

55g

potassium chloride

3g

Magnesium Chloride (MgCl 2 ·6H 2 O)

3g

Calcium gluconate (C 12 h 22 CaO 14 ·H 2 O)

11.2g

Sodium acetate (C 2 h 3 NaO 2 ·3H 2 O)

34g

sodium gluconate

50g

Zinc gluconate

73mg

Water for Injection

Add to 10L

[0047] Preparation:

[0048] 1. Take 8L water for injection at about 50°C, weigh in the ingredients of the prescribed amount in turn, stir to dissolve, add 0.1% activated carbon for needles, stir well, let stand for 30 minutes, and decarbonize through 0.45μm membrane filtration.

[0049] 2. Add water for injection to the filtrate to make the volume of the liquid medicine 10L, and stir well.

[0050] 3. Fine filtration of liquid medicine with 0.22μm filter membrane.

[0051] 4. The fine filtrate is potted and sealed in infusion bottles, 500ml per bottle.

...

Embodiment 3

[0056] Embodiment 3: prepare 20 bottles, every bottle 500ml:

[0057] Sodium chloride

49.8g

potassium chloride

3.7g

Magnesium Chloride (MgCl 2 ·6H 2 O)

1.3g

Calcium Chloride (CaCl 2 2H 2 O)

4.0g

Sodium acetate (C 2 h 3 NaO 2 ·3H 2 O)

34g

sodium gluconate

76g

Zinc sulfate (ZnSO 4 ·7H 2 O)

88mg

Water for Injection

Add to 10L

[0058] Preparation:

[0059] 1. Take 6L of water for injection at about 70°C, weigh the ingredients in the prescribed amount in turn, stir to dissolve, add 0.1% activated carbon for needles, stir well, let stand for 20 minutes, and decarbonize through 0.45μm membrane filtration.

[0060] 2. Add water for injection to the filtrate to make the volume of the liquid medicine 10L, and stir well.

[0061] 3. Fine filtration of liquid medicine with 0.22μm filter membrane.

[0062] 4. The fine filtrate is potted and sealed in infusion bottles, 500ml per bo...

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Abstract

The invention discloses a glucose-free novel electrolyte injection and relates to the technical field of chemical drugs. Inorganic salts of macroelements including Na, K, Mg, Ca and Cl, an inorganic salt of a trace element Zn and a representative acidosis correction drug which are required by fluid infusion therapy for isotonic dehydration are adopted for composition according to the pathology of a patient after a trauma or operation, clinical signs and basic features of organism metabolic reactions, the concentration of inorganic salt ions in a solution of the injection is consistent with the normal concentration of human blood, and pH is closer to the normal pH of the human blood. The glucose-free novel electrolyte injection is clinically used for maintaining water and electrolyte balance of the patient after the trauma or operation, improving the cycling capacity and correcting metabolic acidosis and has great clinical application significance in stabilization of an intracellular environment, guarantee of physiological functions of important vital organs and life sustaining.

Description

technical field [0001] The present invention relates to containing Na + 、K + , Mg 2+ , Ca 2+ , Zn 2+ , Cl - and acid correcting drugs, electrolyte injection without sugar and preparation method thereof. Specifically, the present invention supplements the macroelements, trace elements and acid-correcting drugs necessary for the physiology of the body according to the pathology, clinical signs, and metabolic reactions of the patient after trauma and surgery, so as to maintain the balance of water and electrolytes in the body, Restore circulation capacity, correct metabolic acidosis, and prevent adverse reactions caused by infusion of glucose. Background technique [0002] Clinical rehydration therapy is mainly to supplement crystal solution and colloid solution. With the development of clinical medicine and the popularization of minimally invasive surgery, the amount of blood loss caused by surgery is getting less and less. Most of the operations can control the hemoglo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/14A61K9/08A61P3/02A61K33/06A61K31/19A61K31/194A61K31/191A61K31/315
CPCA61K9/0019A61K9/08A61K31/19A61K31/191A61K31/194A61K33/06A61K33/14A61K33/30A61K2300/00
Inventor 谭安德张奇华
Owner CHANGSHA LIXING MEDICAL TECH CO LTD
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