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Preparation method of externally applied functional ointment for traumatic wounds

A functional and invasive technology, applied in pharmaceutical formulations, pharmaceutical science, drug delivery, etc., can solve problems such as decreased biocompatibility, improve antibacterial properties, reduce costs, and make up for weak antibacterial properties.

Active Publication Date: 2016-04-20
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Chinese patent application CN201310695850.3 discloses "a kind of self-crosslinking gel and its preparation method and application", which has the disadvantages of decreasing biocompatibility due to containing polyethylene oxide, polyvinyl alcohol and aluminum salt alum

Method used

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  • Preparation method of externally applied functional ointment for traumatic wounds
  • Preparation method of externally applied functional ointment for traumatic wounds
  • Preparation method of externally applied functional ointment for traumatic wounds

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The preparation method is as follows:

[0039]The first step, take by weighing sodium alginate 5Kg and carboxymethylated chitin 50Kg respectively, standby;

[0040] Put sodium alginate in a container, add distilled water to prepare 500Kg of a sodium alginate aqueous solution with a concentration of 1% by mass; place carboxymethylated chitin in a container, add distilled water to prepare a concentration of 10% by mass modified chitin aqueous solution 500Kg;

[0041] Then, the above-mentioned modified chitin aqueous solution was added to the above-mentioned sodium alginate aqueous solution while stirring; and the stirring was continued for 60 minutes, so that the fit reaction between the two was complete, and after concentration, the hygroscopic supramolecular GCP was obtained;

[0042] In the second step, press Ag + The mass ratio to GCP is 3:1000, add silver nitrate solution to the hygroscopic supramolecular GCP, and stir for 30-60 minutes to make the two undergo a co...

Embodiment 2

[0047] Except that silver nitrate is replaced with silver acetate; All the other are with embodiment 1.

Embodiment 3

[0049] Except that ascorbic acid 296.5g is replaced with vanillin 256.1g; all the other are the same as in Example 1.

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Abstract

The invention discloses a preparation method of an externally applied functional ointment for traumatic wounds. The method comprises the steps that marine biological resource sodium alginate and modified chitin are taken as the raw materials, an ionic bonding reaction, a silver ion complexing reaction and a nano-silver reaction are conducted, a natural antibacterial enhancer capable of moistening and repairing skin injuries and a nano-silver anti-photosensitivity agent are added, and the externally applied functional ointment, namely, a silver liquid band-aid product with a golden appearance, for the traumatic wounds is prepared, wherein the functional ointment is capable of meeting an emergency, convenient to use, rapid in film formation, rapid in hemostasis and sterilization and capable of bonding, relieving itching and moistening and repairing the skin injuries. The prepared product can serve as a liquid band-aid, has the effects of stopping bleeding, relieving itching, repairing skin, promoting healing and reducing scars and has the advantages of being rapid in film formation, easy to remove, free of off-flavors, suitable for hemostasis and sterilization of skin traumas and suitable for an adjuvant therapy of skin itching relieving or dermatophytosis or eczema and an adjuvant therapy of skin injury surfaces of scalds, burns and the like.

Description

technical field [0001] The invention relates to a preparation method of a functional ointment for external application on wounds, belonging to the field of marine biopharmaceuticals. Background technique [0002] It is unavoidable for people to suffer slight injuries to their limbs during work, life and sports. If left untreated or improperly handled, infection can occur and leave visible scars. Therefore, there have been many inventions of swords, guns and wound medicine since ancient times, and there are also emergency techniques such as pressing soil on the wound, pressing plant ash, and squid bone powder invented by ordinary people. Of course, the success rate is low and the sequelae are self-evident. [0003] At the beginning of the 20th century, the American Johnson & Johnson (J&J) company invented the Band-Aid (Bundy) with a bandage. Band refers to bandages, and Aid means first aid. This is the prototype of the Band-Aid that is currently sweeping the world. In the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0004A61L26/0023A61L26/0057A61L26/0066A61L26/008A61L2300/104A61L2300/404A61L2300/418A61L2300/45A61L2400/04C08L5/04C08L5/08
Inventor 李子超郭培志李群薛云刘芳芳王力平朱善富李姣
Owner QINGDAO UNIV