Tissue structure-guided composite regularized bioluminescence tomography reconstruction method
A technology of tissue structure and bioluminescence, applied in the field of medical image processing, can solve problems such as equalization
Active Publication Date: 2018-06-01
BEIJING UNIV OF TECH
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In addition, when the tissue where the tumor is located cannot be determined, the tissue weight may need to be equally divided
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[0047] The present invention will be described in more detail below in conjunction with the accompanying drawings and embodiments.
[0048] In order to test the validity of the method proposed by the present invention, it is verified by phantom experiments. In the experiment, considering the spectral distribution, the two selected spectral bands are 600nm and 630nm respectively, and it is considered that the optical characteristic parameters of biological tissues are known. The detailed parameters are shown in Table 1, and the specific structure diagram is shown in figure 1 and figure 2 shown.
[0049] Table 1 Optical characteristic parameters of biological tissue
[0050]
[0051] The present invention uses a finite element method to generate forward boundary measurement data. In order to effectively avoid "reverse behavior", when generating forward data, the grid of forward data contains 3508 nodes, and the grid required for reconstruction contains 1309 nodes.
[0052]...
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The invention provides a tissue structure guided composite regularization BLT (Bioluminescence Tomography) rebuilding method, and belongs to the field of medical image processing. By aiming at the problems in the existing BLT rebuilding algorithm, the light source rebuilding can be well realized under the conditions that a biological tissue at which a tumor grows is known but the concrete position is known by the method; and under the condition that the biological tissue at which the tumor grows is unknown, the rebuilding is realized through an equal division weight coefficient. Firstly, a finite element method is used for emulating the transmission of light in biological tissues; on the basis of the sparse distribution features of a light source in the BLT imaging, more prior information is fused by using a structure imaging guided composite regularization method so as to reduce the morbidity of the BLT rebuilding; and finally, the accurate rebuilding of a fluorescent light source is realized on the basis. Two light sources are arranged in the two wave bands for performing a simulation experiment so as to verify the effectiveness and the accuracy of the algorithm. The method has the advantages that the fluorescent light source can realize accurate rebuilding and positioning, and the calculation efficiency can be greatly improved.
Description
technical field [0001] The invention belongs to the field of medical image processing, and relates to a composite regularized bioluminescent tomography reconstruction algorithm guided by tissue structure. Background technique [0002] Optical molecular imaging is a rapidly developing molecular imaging technology. It combines optical processes with certain molecular properties to analyze and process bioluminescence or excited fluorescence in the target body, and conduct qualitative and quantitative research. [0003] The most representative imaging methods in optical molecular imaging technology are fluorescence imaging technology (Fluorescence Imaging) and bioluminescence imaging technology (Bioluminescence Imaging, BLI). They are all two-dimensional bioluminescent imaging technologies. Although this imaging technology is convenient and simple to apply, there are limitations in the application of this two-dimensional imaging method, especially for the limitation of imaging d...
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IPC IPC(8): A61B5/00
CPCA61B5/72
Inventor 冯金超魏慧军贾克斌
Owner BEIJING UNIV OF TECH