Preparation method of novel oxycellulose hemostatic product

A technology for oxidizing cellulose and cellulose, applied in the fields of pharmaceutical formulation, application, medical science, etc., can solve problems such as harm to the human body and the environment, and achieve the effects of strong liquid absorption, soft texture, and increased specific surface area.

Active Publication Date: 2016-05-11
ZHEJIANG UNIVERSITY OF SCIENCE AND TECHNOLOGY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the general sponge is composed of polystyrene, polyurethane and

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Wood fiber is used as raw material, and the fiber fineness is 0.5 denier.

[0039] 1. The cellulose fibers are pretreated with a 1% sodium hydroxide solution, and after removing possible impurities, the surface of the fibers is further activated with an alkali solution.

[0040] 2. After pretreatment and activation, wash with deionized water until neutral, and air-dry the obtained cellulose product to obtain raw materials.

[0041] 3. Use 5% sodium hydroxide solution as a solvent, the dosage of cellulose product is 3% (in sodium hydroxide solution), then add 2% urea (in sodium hydroxide solution) and 2% ZnO ( (calculated as sodium hydroxide solution), fully dissolved at -15°C, and the system becomes viscose.

[0042] 4. After the fiber is completely dissolved in the solution and becomes viscose, slowly add the pore-forming agent sodium sulfate, and continue to stir for 20 minutes to make it a mixture of cellulose.

[0043] 5. Pour the cellulose mixture into the mold f...

Embodiment 2

[0055] Viscose fiber is used as raw material, and the fiber fineness is 1.0 denier.

[0056] 1. Pretreat the cellulose fibers with a 3% sodium hydroxide solution to remove impurities on the surface of the fibers, and then activate the surface of the fibers with an alkali solution.

[0057] 2. After pretreatment and activation, wash with deionized water until neutral, and air-dry the obtained cellulose product to obtain raw materials.

[0058] 3. Use 10% sodium hydroxide solution as a solvent, and the dosage of cellulose product is 5% (in sodium hydroxide solution), then add 2% urea (in sodium hydroxide solution) and 2% ZnO ( Calculated as sodium hydroxide solution), fully dissolved at -5°C, the system becomes viscose.

[0059] 4. After the fiber is completely dissolved in the solution and becomes viscose, slowly add the pore-forming agent sodium sulfate, and continue to stir for 20 minutes to make it a mixture of cellulose.

[0060] 5. Pour the cellulose mixture into the mol...

Embodiment 3

[0072] Cotton fiber is used as raw material, and the fiber fineness is 3.0 denier.

[0073] 1. Pretreat the cellulose fibers with a 5% sodium hydroxide solution, remove impurities on the surface of the fibers, and then activate the surface of the fibers with an alkali solution.

[0074] 2. After pretreatment and activation, wash with deionized water until neutral, and air-dry the obtained cellulose product to obtain raw materials.

[0075] 3. Use 20% sodium hydroxide solution as a solvent, the amount of cellulose product is 10% (in sodium hydroxide solution), then add 2% urea (in sodium hydroxide solution) and 2% ZnO ( (calculated as sodium hydroxide solution), fully dissolved at 5°C, and the system becomes viscose.

[0076] 4. After the fiber is completely dissolved in the solution and becomes viscose, slowly add the pore-forming agent sodium sulfate, and continue to stir for 20 minutes to make it a mixture of cellulose.

[0077] 5. Pour the cellulose mixture into the mold ...

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Abstract

The invention discloses a preparation method of a novel oxycellulose hemostatic product; the preparation method comprises the steps: pre-treating a cellulose product with a sodium hydroxide solution with the concentration of 1%-5%, removing lignin or impurities on a fiber surface, and further carrying out activation treatment on the fiber surface with an alkali solution; after pretreatment and activation, washing with deionized water to be neutral, and air-drying the obtained cellulose product in air to obtain a raw material; taking a sodium hydroxide solution with the concentration of 5%-20% as a solvent, taking the cellulose product with the amount of 3-10% of the sodium hydroxide solution, then adding urea with the amount of 2% of the sodium hydroxide solution and ZnO with the amount of 2% of the sodium hydroxide solution, and implementing other steps. The physical properties of cellulose fibers are directly changed, the porosity of the cellulose product is greatly increased, the specific surface area of the product is increased, the strength of the product is also increased, the crystalline morphology structure of cellulose is improved, and the changes are greatly beneficial for the next step of selective oxidation reaction of the product.

Description

technical field [0001] The invention relates to the field of cellulose hemostatic products, in particular to a preparation method of a novel oxidized cellulose hemostatic product (hemostatic sponge). Background technique [0002] Cellulose is a macromolecular polysaccharide composed of glucose. Insoluble in water and general organic solvents. It is the main component of plant cell walls. Cellulose is the most widely distributed and most abundant polysaccharide in nature, accounting for more than 50% of the carbon content in the plant kingdom. The cellulose content of cotton is close to 100%, which is the purest natural cellulose source. . Cellulose is a natural polymer compound formed by linking D-glucopyranose. [0003] Oxidized cellulose and oxidized regenerated cellulose, due to their good biocompatibility and degradability, can be used as hemostatic gauze products in the medical field. After the oxidized cellulose is made into medical gauze, its carboxyl group can cr...

Claims

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Application Information

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IPC IPC(8): A61L24/08
CPCA61L24/08A61L2400/04C08L1/02A61L24/0036C08B15/04C08L1/04
Inventor 张治国索艳格黄伟孙伟庆
Owner ZHEJIANG UNIVERSITY OF SCIENCE AND TECHNOLOGY
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