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System and signatures for multi-modal physiological stimulation and assessment of brain health

A stimulation device, user technology, applied in applications, psychological devices, electrical digital data processing, etc., can solve the problems of cumbersome equipment, a large number of operator training, etc.

Inactive Publication Date: 2016-05-18
CERORA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, formal laboratory-based EEG methods generally require extensive operator training, cumbersome equipment, and are primarily used to detect epilepsy

Method used

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  • System and signatures for multi-modal physiological stimulation and assessment of brain health
  • System and signatures for multi-modal physiological stimulation and assessment of brain health
  • System and signatures for multi-modal physiological stimulation and assessment of brain health

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0150] Example 1. TIRHR Concussion Study

[0151] In collaboration with the non-profit medical institution in the foothills near Lake Tahoe, under the supervision of the institutional review board, two groups of subjects were recruited in the clinical trial protocol approved by the institutional review board, wherein the first group of subjects ( Group A) were clinically diagnosed with concussion (mTBI) or mild traumatic brain injury, while a second control group of subjects (Group B) were recruited without any problems with concussion and were used as controls (CTL). Participants from both group A and group B were scanned identically using an electronic REM module comprising a single electrode EEG device as described in PCT patent application PCT / US2012 / 046723 filed on July 13, 2012. The 5 minute scanning protocol consisted of eyes closed for 30 seconds, eyes opened for 30 seconds, the King-Devick test performed for approximately 3 minutes and then concluded with eyes closed ...

example 2

[0155] Example 2. Lehigh University Sports Medicine Concussion Research

[0156]In collaboration with National Collegiate Athletic Association (NCAA) Division 1 universities, several cohorts of subjects were enrolled in an institutional review board-approved clinical trial protocol, where the first cohort of subjects (Cohort A) were clinically diagnosed with concussion (mTBI) or mild traumatic brain injury, a second control group of subjects (group B) without any concussion issues was recruited and used as a non-injured control subject (CTL), recruited from other Other athletes in the sport (Group C, etc.). As described in PCT Patent Application No. PCT / US2012 / 046723 filed on July 13, 2012, participants from Group A, Group B, Group C, and others were assessed using an electronic REM module that included a single-electrode EEG device. Same scan. The 22- to 24-minute scanning protocol included 1 minute with eyes closed, 1 minute with eyes open, and automated application from t...

example 3

[0168] Example 3. Rothman Concussion Study

[0169] In collaboration with clinical practice and concussion experts, two groups of subjects were recruited in an institutional review board-approved clinical trial protocol, in which the first group of subjects (Group A) were clinically diagnosed with concussion (mTBI) or mild trauma With brain injury, a second control group of subjects recruited (Group B) did not have any issues with concussion and was used as a control (CTL) and was recruited under the supervision of an institutional review board. Participants from Group A, Group B were scanned identically as described in PCT Patent Application No. PCT / US2012 / 046723 filed on July 13, 2012, using an electronic REM module comprising a single electrode EEG device. The 25-minute scanning protocol consisted of 1 minute with eyes closed, 1 minute with eyes open, and then when the student-athlete was using the head electronics REM module that streamed the EEG data to a nearby periphera...

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Abstract

A system and diagnostic signatures which are derived from the data collected in the system captures multiple streams of biological sensor data for assessing brain health and functionality of a user. The system includes a plurality of biological sensors adapted to collect biological sensor data from the user as well as the ability to stimulate the brain in a variety of sensory, cognitive, physical, and chemical challenges. The biological sensors include an active brainwave sensor that collects at least one channel of EEG brainwave data in addition to one or more additional biological sensor data streams selected from among accelerometer measures of balance and movement, microphone measurements of voice and response, image sensor to track eye movement and biometric identification, pulse oximetry measurements of heart rate, heart rate variability, and arterial oxygen, Galvanic skin conductance (or Dermal skin conductance) for emotional and mood information, cognitive data in the form of key strokes, and mouse clicks or touch screen events during cognitive challenges. A plurality of the biological sensors are accommodated in an electronics module mounted on the user's head.

Description

[0001] Cross References to Related Applications [0002] This application claims U.S. Provisional Application No. 61 / 799,842, filed March 15, 2013, U.S. Provisional Application No. 61 / 836,294, filed June 18, 2013, and U.S. Provisional Application No. 61 / 836,294, filed January 29, 2014. Application No. 61 / 932,915 benefits. The contents of these patent applications are hereby incorporated by reference in their entirety. technical field [0003] The present invention relates to the diagnosis and analysis of brain health by using activated tasks and stimuli in a system to dynamically assess an individual's brain state and function. Background technique [0004] The proper function of the brain and central nervous system is essential to a healthy, enjoyable and productive life. Disorders of the brain and central nervous system are among the most dreadful diseases. Many neurological conditions, such as stroke, Alzheimer's disease, and Parkinson's disease, are insidious and prog...

Claims

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Application Information

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IPC IPC(8): A61B8/00A61B5/00A61B5/05G10L13/00G10L21/00G06F15/00
CPCA61B5/024A61B5/1118A61B5/14542A61B5/16A61B5/4064A61B5/4088A61B5/163A61B5/02405A61B5/0533A61B5/6803A61B5/381A61B5/38A61B5/378A61B5/291
Inventor 亚当·J·西蒙
Owner CERORA