Method for preparing antimicrobial surface on biological medical material surface

A biomedical material, surface amination technology, applied in coating and other directions, can solve the problems of complex reaction process and limited substrate, and achieve the effect of simple operation, wide applicability, and easy reaction conditions

Active Publication Date: 2016-05-25
JIANGSU BIOSURF BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to overcome the problems of complex reaction process and limited substrates in the existing antibacterial surface preparation methods, and provide a simple and universal antibacterial surface preparation method

Method used

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  • Method for preparing antimicrobial surface on biological medical material surface
  • Method for preparing antimicrobial surface on biological medical material surface

Examples

Experimental program
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Effect test

Embodiment 1

[0060] Combining layer-by-layer assembly technology and host-guest interaction to prepare antibacterial surfaces on the surface of single crystal silicon wafers

[0061] The monocrystalline silicon wafers cleaned ultrasonically with acetone solution were pretreated with "piranha" solution (sulfuric acid: hydrogen peroxide = 7:3, volume ratio), and then placed in 3-aminopropyl-triethoxysilane (APTES) react in a toluene solution for 18 hours to obtain a monocrystalline silicon wafer with surface amination. A polyanion P(AA-Ada) solution and a polycation PAH solution were prepared respectively, and the solvent was acetic acid / sodium acetate buffer solution with a pH value of 5.0 and a concentration of 0.05 mol / liter. Soak the aminated monocrystalline silicon wafer in the P(AA-Ada) solution, wash it with acetic acid / sodium acetate buffer solution to remove the weakly bonded polymer, and then soak it in the PAH solution. After cleaning, a P (AA-Ada) / PAH bimolecular layer, this pro...

Embodiment 2

[0065] Combining layer-by-layer assembly technology with host-guest interaction to prepare antibacterial surface on glass surface

[0066] The glass slides ultrasonically cleaned with acetone solution were pretreated with "piranha" solution (sulfuric acid: hydrogen peroxide = 7:3, volume ratio), and then placed in 3-aminopropyl-triethoxysilane (APTES) toluene After reacting in the solution for 18 hours, the surface-aminated glass flakes were obtained. A polyanion P(AA-Ada) solution and a polycation PAH solution were prepared respectively, and the solvent was acetic acid / sodium acetate buffer solution with a pH value of 5.0 and a concentration of 0.05 mol / liter. Soak the aminated glass piece in the P(AA-Ada) solution, wash it with acetic acid / sodium acetate buffer solution to remove the weaker polymer, and then soak it in the PAH solution. After cleaning, a P(AA-Ada) is obtained on the surface. -Ada) / PAH bimolecular layer, this process is repeated several times to finally reac...

Embodiment 3

[0070] Combining layer-by-layer assembly technology with host-guest interaction to prepare antibacterial surface on the surface of gold-plated single crystal silicon wafer

[0071] Pretreat the gold-plated single crystal silicon wafers cleaned by the UV-ozone meter with a mixed solution of ammonia, hydrogen peroxide and deionized water (ammonia: hydrogen peroxide: deionized water = 1:1:5, volume ratio), and then place React overnight in an aqueous solution of mercaptoethylamine hydrochloride to obtain a gold-plated single-crystal silicon chip whose surface is aminated. A polyanion P(AA-Ada) solution and a polycation PAH solution were prepared respectively, and the solvent was acetic acid / sodium acetate buffer solution with a pH value of 5.0 and a concentration of 0.05 mol / liter. Soak the aminated gold-plated single crystal silicon wafer in the P(AA-Ada) solution, wash it with acetic acid / sodium acetate buffer solution to remove the weakly bonded polymer, and then soak it in th...

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Abstract

The invention relates to a method for preparing antimicrobial surface on a biological medical material surface. The method comprises the following steps: carrying out amination treatment on multiple substrates with different properties; depositing a polyelectrolyte containing guest molecule adamantyl group onto the aminated substrate surface by a layer-by-layer packaging technique to prepare a polyelectrolyte multilayer film; and finally, immobilizing quaternary-ammonium-salt-modified beta-cyclodextrin derivatives on the polyelectrolyte multilayer film surface under the mutual actions of the host and guest, thereby finally preparing the antimicrobial surface. The method has universality, and is suitable for multiple substrates with different properties and shapes. The prepared antimicrobial surface has broad-spectrum mold resistance.

Description

technical field [0001] The invention relates to the field of biomedical functional polymer materials, in particular to a method for preparing an antibacterial surface by combining layer-by-layer assembly technology and host-guest interaction. Background technique [0002] The adhesion of bacteria on the surface of biomaterials and the subsequent formation of biofilms can cause a series of biological infection problems such as failure of medical implanted devices, tissue infection and inflammation. Therefore, how to simply, efficiently and universally modify the surface of biomaterials to construct antibacterial surfaces is of great significance. [0003] In the past few decades, many methods for constructing antibacterial surfaces have been proposed, including graft polymerization, self-assembled monolayer method, layer-by-layer assembly method, etc. Among them, the layer-by-layer assembly method is a modification method that alternately deposits oppositely charged polymers...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/12C08J7/14C03C17/42C08L83/04C08L75/04
CPCC03C17/42C03C2217/70C03C2218/111C03C2218/31C08J7/12C08J7/14C08J2375/04C08J2383/04
Inventor 陈红于谦韦婷占文俊曹利敏渠阳翠胡昌明
Owner JIANGSU BIOSURF BIOTECH CO LTD
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