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Application of thymoquinone to preparation of drug for prevention and treatment of brain damage caused by status epilepticus

A technology for status epilepticus and thymoquinone is applied in the application field of thymoquinone in the preparation of drugs for preventing and treating brain injury in status epilepticus

Inactive Publication Date: 2016-06-01
JINSHAN HOSPITAL FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no report on the role of thymoquinone in the prevention and treatment of brain injury in status epilepticus

Method used

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  • Application of thymoquinone to preparation of drug for prevention and treatment of brain damage caused by status epilepticus
  • Application of thymoquinone to preparation of drug for prevention and treatment of brain damage caused by status epilepticus
  • Application of thymoquinone to preparation of drug for prevention and treatment of brain damage caused by status epilepticus

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Embodiment 1

[0024] 1 Research Methods

[0025] 1.1 Establishment of procarpine-lithium chloride-induced status epilepticus rat model

[0026] Male SD rats, 160-180g. Rats were intraperitoneally injected with lithium chloride (3mg / kg), and then intraperitoneally injected with pilocarpine (30mg / kg) after 20 hours. About 15 minutes after the injection of pilocarpine, the rats will appear seizure behavior. The seizure records and grades are in accordance with the Racine scoring standard: grade 0: no reaction; grade 1: fixed behavior, facial muscle twitching; grade 2: nodding and wet dog grade 3: bilateral forelimb clonus; grade 4: forelimb clonus and hind limb stance; grade 5: stand and fall. After the rats had continuous seizures of grade 4 or above and lasted for 60 minutes, diazepam (10 mg / kg) was given to terminate the seizures. During modeling, the control group was given an equal volume of normal saline by intraperitoneal injection. Two days before modeling, the rats were given past...

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Abstract

The invention relates to application of thymoquinone to preparation of a drug for prevention and treatment of brain damage caused by status epilepticus. Observations of the influence of thymoquinone on rate brain damage caused by status epilepticus show that the death of an animal caused by status epilepticus is effectively reduced after the animal is fed with thymoquinone before status epilepticus chemical kindling, the animal electroencephalogram seizure incubation period and total power are obviously reduced, Racine grading is obviously lowered, the incubation periods in a water maze test and a dark avoidance test are obviously shortened, and expressions of Nrf2, HO-1 and SOD are obviously increased. The results prove that thymoquinone can improve the brain electricity, seizure grade and learning and memory ability during status epilepticus, thereby having a prevention and treatment function on brain damage caused by status epilepticus and being remarkable in the prevention and treatment effect.

Description

technical field [0001] The invention relates to a new pharmaceutical application of the compound, in particular to the application of thymoquinone in the preparation of drugs for preventing and treating brain injury in status epilepticus. Background technique [0002] Status epilepticus (status epilepticus, SE) refers to frequent epileptic seizures without complete recovery of consciousness between consecutive seizures, or seizures that last for more than 30 minutes and do not stop spontaneously. Status epilepticus can produce permanent brain damage, and a grand mal status epilepticus can reduce the patient's cognitive function by 8% to 26%. Clinical studies have found that patients with status epilepticus have seizure-related neurological deficits and corresponding imaging changes, such as T2WI hyperintensity and brain atrophy. Pathological studies have also confirmed the presence of pathological changes in the hippocampus, limbic system, cortex, and cerebellum in patients...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/122A61P25/08A61P25/28
CPCA61K31/122
Inventor 陈英辉邵一叶李炳罗琼谢阳梅
Owner JINSHAN HOSPITAL FUDAN UNIV