Alkyne compounds as well as preparation method and application thereof

A technology of alkyne compounds and compounds, which is applied in the field of extraction of alkyne compounds and active ingredients of traditional Chinese medicine, and can solve the problems of no activity or toxicity of other compounds
CN105646151AActive Publication Date: 2016-06-08SHANXI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANXI UNIV
Publication Date
2016-06-08

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Abstract

The invention provides alkyne compounds as well as a preparation method and an application thereof and belongs to the technical field of extraction of alkyne compounds and effective ingredients of traditional Chinese medicines. Specifically, new compounds I, II and IV as well as a reported compound III are obtained from dried roots of Umbeliferae Bupleurum Radix Bupleuri through extraction and separation. In-vitro monoamine neurotransmitter reuptake inhibition experiments are conducted on the compounds, results indicate that the compounds I, II, III and IV have inhibition effects on reuptake of NA (noradrenaline), have the inhibition effects equivalent to that of positive control drug desipramine and have different degrees of inhibition effects on reuptake of 5-HT (5-hydroxytryptophan). The four compounds have anti-depression activity and are expected to be developed into drugs or prodrugs for preventing and treating anti-depression related diseases.
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Description

technical field

[0001] The invention relates to the technical field of extraction of acetylenic compounds and active ingredients of traditional Chinese medicines, in particular to an acetylenic compound, a method for separating the acetylenic compound from Bupleurum bupleuri, and the use of the acetylenic compound. Background technique

[0002] Depression is a common mental illness characterized by high morbidity, relapse and disabling rates. Modern medical research shows that the pathogenesis of depression is complex, with many causes and various clinical symptoms. Most experts and scholars believe that the monoamine hypothesis of depression is that depression is caused by the deficiency of monoamine neurotransmitters in the human brain, 5-HT, NA or DA. The main antidepressants currently used clinically increase the concentration of monoamine transmitters in the synaptic cleft by inhibiting the reuptake of 5-HT and NA in the synaptic cleft. However, synthetic antidepressa...

Claims

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