Chemical synthesis process of hydroxy quinocetone

A chemical synthesis and quinolone technology, applied in the chemical synthesis process field of quinolone, can solve the problems of not being suitable for large-scale production, low production efficiency, complicated production process, etc. efficiency, improve work efficiency, and overcome the effect of more processes

Inactive Publication Date: 2016-06-08
吕艳
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Problems solved by technology

In the current quinolone synthesis process method, the technological process is not easy to implement, the resulting quinolone product has low purity, the single-pass conversi

Method used

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Embodiment

[0011] The chemical synthesis process of the quinolone of the present embodiment comprises the following steps:

[0012] (1) Dissolve 14.3g of o-nitroaniline in 50g of methanol, add 24.3g of 70% sodium hydroxide aqueous solution, continue to stir at 15°C, slowly add 107g of sodium hypochlorite aqueous solution, after the dropwise addition is completed, under 15°C Stirring was continued for 2 hours, and the aqueous phase was separated. The methanol solution of benzofurazan-1-oxide was obtained, washed with water, and filtered to obtain benzofurazan-1-oxide;

[0013] (2) Dissolve 14.2g of benzofurazan-1-oxide and 11.5g of acetylacetone in 40ml of triethylamine, let the solution stand at room temperature, collect the precipitate, and dry it to obtain 2-acetyl Base-2 methylquinoxaline-1,4 dioxide, recrystallized with methanol to obtain pure product;

[0014] (3) Dissolve 5g of 2-acetyl-2-methylquinoxaline-1,4 dioxide in 20ml of 1,6-dioxane, add 3g of salicylaldehyde, at 90°C, sl...

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Abstract

The present invention discloses a chemical synthesis process of hydroxy quinocetone. In the existing synthesis technology, the substituted derivatives of a variety of quinoxaline compounds are selected, but the compounds have high toxic-side effects, and the requirements cannot be met by simply changing the side chains. According to the present invention, heavy ion beam is used to transform the structure of quinoxaline to generate the new compound molecule, and with the pharmacodynamic research, the standard sample is separated and chemical synthesis is performed; three synthesis routes are designed and are corresponding to three chemical synthesis processes, the new compound is subjected to spectroscopy identification, the new compound is determined as hydroxy quinocetone, and the further growth promoting and toxicity test results show that the hydroxy quinocetone provides significant improvement compared with the lead compound quinocetone; and the process has beneficial effects of substantially-shortened research period and substantially-saved research cost, and the research results show that the hydroxy quinocetone is the extremely viable veterinary feed additive.

Description

technical field [0001] The invention belongs to the technical field of chemical synthesis, and in particular relates to a chemical synthesis process of quinolone. Background technique [0002] The chemical synthesis process of quinolone at least includes processes such as suction filtration, precipitation, washing, and filtration. In the current quinolone synthesis process method, the technological process is not easy to implement, the resulting quinolone product has low purity, the single-pass conversion rate of the reactant is low, the production process is complicated, the production efficiency is low and the cost is high, and it is not suitable for large-scale production. . Contents of the invention [0003] In order to overcome the above-mentioned technical problems existing in the prior art field, the object of the present invention is to provide a kind of chemical synthesis process of quinolone. The present invention not only has simple production process and i...

Claims

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Application Information

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IPC IPC(8): C07D241/52
Inventor 吕艳
Owner 吕艳
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