Polyamino acid gel and preparation method and application thereof

A technology of polyamino acid gel and polyamino acid, applied in pharmaceutical formulations, cosmetic preparations, dressing preparations, etc., can solve the problems of non-compliance with new zero additives, narrow application fields, single dosage forms, etc., to increase skin elasticity , Improve the effect of mechanical strength and toughness

Active Publication Date: 2016-06-22
NANJING SHINEKING BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the hydrogel prepared by a single γ-polyglutamic acid has no antibacterial function, a single dosage form, and narrow application fields, and does not meet the requirements of new zero-additive skin care products.

Method used

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  • Polyamino acid gel and preparation method and application thereof
  • Polyamino acid gel and preparation method and application thereof
  • Polyamino acid gel and preparation method and application thereof

Examples

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Comparison scheme
Effect test

preparation example Construction

[0052] A preparation method of a polyamino acid gel, the preparation method comprising the following steps: putting the above components into a reactor with stirring function, adding a small amount of hydrochloric acid or sodium hydroxide to adjust the pH of the solution to 3-13, stirring for 15 ~60min, repeatedly adjust the pH of the solution, and let it stand at room temperature for 12~36h to complete the self-assembly of macromolecules and form a paste-like polyamino acid gel.

[0053] The application of the polyamino acid gel of the present invention in the preparation of facial mask or lotion, nutritional cream, essence, eye cream, hand cream, shampoo, hair conditioner and sunscreen.

[0054] Such as figure 1 As shown, the polyamino acid hydrogel facial mask of the present invention is a double network hydrogel made of the polyamino acid gel of the present invention, and the double network hydrogel includes at least one layer made of cyclodextrin The formed self-assemble...

Embodiment 1

[0060] A polyamino acid gel, calculated in parts by mass, its composition and consumption are as follows:

[0061]

[0062] The preparation method specifically comprises the following steps:

[0063] Weigh the above raw materials respectively and put them into the reaction equipment with stirring function, add a small amount of hydrochloric acid to adjust the pH to 6.5, stir for 30 minutes, and rotate at 100 rpm, then adjust the pH of the material liquid to 6.5, and let it stand at room temperature for 24 hours to form a transparent, uniform Liquid polyamino acid gel.

[0064] The obtained polyamino acid gel is added to the basic emulsion, which has a significant multiplied moisturizing effect on the active ingredients, which increases the overall moisturizing effect of the product by 45%, and improves the long-term moisturizing effect of the product.

Embodiment 2

[0066] A polyamino acid gel, calculated in parts by mass, its composition and consumption are as follows:

[0067]

[0068] The preparation method specifically comprises the following steps:

[0069] Weigh the above raw materials respectively and put them into the reaction equipment with stirring function, add a small amount of sodium hydroxide to adjust the pH to 8, stir for 40 minutes, and the rotation speed is 120rpm, then adjust the pH of the material liquid to 8, and let it stand at room temperature for 30 hours to obtain a transparent, viscous polyamino acid gel.

[0070] Adding the above-mentioned polyamino acid gel to the basic emulsion has a significant multiplied moisturizing effect on the active ingredients, which increases the overall moisturizing effect of the product by 45%, and improves the long-term moisturizing effect of the product to nourish the skin. Remove fine lines and solve the five major problems of light and mature skin.

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Abstract

The invention discloses a polyamino acid gel and a preparation method and an application thereof. The polyamino acid gel is prepared from the following raw materials in percentage by mass: 1% to 8% of gamma-polyglutamic acid, 1% to 4% of epsilon-polylysine, 3% to 18% of alpha-cyclodextrin, 70% to 95% of water and the balance of functional ingredients. The polyamino acid gel has the advantages that the polyamino acid gel can be applied into masks or emulsions, nourishing creams, essences, eye creams, hand creams, cream shampoos, hair conditioners and sun creams, and can be used as an additive; the polyamino acid gel can be used as a washing-free mask, and can also be irradiated to obtain a polyamino acid gel mask with a double-network structure; by utilizing macromolecule self-assembly and chemical crosslinking, the cream type polyamino acid gel is obtained, the mechanical strength of a polymer gel is improved, and the introduction of harmful chemical matters caused by using a hair initiator in the polymerizing process is avoided.

Description

technical field [0001] The invention relates to the field of biopolymer daily chemical products, in particular to a polyamino acid gel and its preparation method and application. Background technique [0002] The facial masks currently on the market can be classified into the following types: washing facial masks, hard masks, soft masks, cream masks, and sticking masks, etc., which are cumbersome to use, have certain risks, and cause damage to the skin. Existing popular non-woven fabrics and silk masks have shortcomings such as dripping essence, poor moisturizing effect, and poor air permeability. γ-polyglutamic acid and ε-polylysine are currently the only two naturally occurring homopolymers of amino acids, both of which are produced by microbial fermentation and can be degraded into amino acid monomers in vivo. Absorbed by the body, no toxic side effects. γ-polyglutamic acid, ε-polylysine and α-cyclodextrin have obvious advantages compared with traditional gel materials,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/88A61K8/04A61K8/73A61K8/97A61K8/64A61K8/67A61Q19/00A61Q19/02A61Q5/02A61Q5/12A61Q17/04A61P37/08A61P17/10
CPCA61K8/042A61K8/64A61K8/676A61K8/73A61K8/735A61K8/738A61K8/88A61K8/97A61Q5/02A61Q5/12A61Q17/04A61Q19/00A61Q19/005A61Q19/02
Inventor 徐虹詹伊婧任战坤殷文锋冯小海
Owner NANJING SHINEKING BIOTECH CO LTD
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