Method for ensuring traditional Chinese medicine quality uniformity through intelligent traditional Chinese medicine fingerprint analysis

A fingerprint and intelligent analysis technology, applied in the field of intelligent analysis of traditional Chinese medicine fingerprints, can solve the problems of manual input of component content, no automation, intelligent calculation, etc., and achieve the effect of convenient observation and analysis.

Inactive Publication Date: 2016-06-22
JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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AI Technical Summary

Problems solved by technology

Most of these methods can only calculate a single solution, a suboptimal solution or a local optimal solution of the blending scheme, and the composition content of each batch of traditional Chinese medicine needs to be manually input, and there is no system from the chromatographic detection to the quality uniformity control of traditional Chinese medicine. An Integrated Approach to Automated, Intelligent Computing

Method used

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  • Method for ensuring traditional Chinese medicine quality uniformity through intelligent traditional Chinese medicine fingerprint analysis
  • Method for ensuring traditional Chinese medicine quality uniformity through intelligent traditional Chinese medicine fingerprint analysis
  • Method for ensuring traditional Chinese medicine quality uniformity through intelligent traditional Chinese medicine fingerprint analysis

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Experimental program
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Effect test

Embodiment Construction

[0105] A fully automatic and intelligent method for blending Chinese herbal medicines to ensure the stability of their ingredients. Taking the blending of kudzu root pieces as an example to introduce the specific implementation process:

[0106] 1. Utilize the high performance liquid phase method (HPLC) to detect the content of the active ingredients of each batch of kudzu root decoction pieces, including: puerarin and daidzin;

[0107] 2. Read the potential data of each batch of traditional Chinese medicine on the detection device, open the data in the memory, and generate the fingerprint of the traditional Chinese medicine. The peak area of ​​the component of the average fingerprint is used as the blending target, and the peak area of ​​the component of the fingerprint of each batch of traditional Chinese medicine is used as the target. Blending data to form a blending data table, see the table below:

[0108]

[0109] 3. Set the blending error, set the maximum allowable ...

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Abstract

The invention provides a method for ensuring traditional Chinese medicine quality uniformity through intelligent traditional Chinese medicine fingerprint analysis. The method includes the steps of obtaining potential data of traditional Chinese medicine of all batches through a chromatographic instrument, converting the potential data into fingerprint spectrum bitmap files, loading the files to a fingerprint spectrum list, directly reading component content data generated by a detection device in an internal storage through interface software, showing the data in the form of tables, displaying overlaid fingerprint spectrum bitmaps in a fingerprint spectrum overlaying and displaying module, displaying mean-value fingerprint spectrums through a fusion fingerprint spectrum module, conducting similarity analysis on all the fingerprint spectrum bitmaps through a fingerprint spectrum similarity analysis module, conducting component peak analysis on all the fingerprint spectrums through a component peak/difference peak module, and blending traditional Chinese medicine of all batches through an intelligent Chinese herbal medicine blending and calculating module. A blending scheme calculated through the method is accurate, reliable and repeatable, and efficiency of the calculation method can be multiplied.

Description

technical field [0001] The invention relates to a method for intelligently analyzing the fingerprints of traditional Chinese medicines to ensure the quality uniformity of traditional Chinese medicines. Background technique [0002] Traditional Chinese medicine is a treasure that the Chinese nation has used for thousands of years to treat diseases and keep fit. The stability of the content of Chinese medicine ingredients is the main requirement in the quality control process of Chinese medicine production, and it is also the premise of whether Chinese medicine can play a key therapeutic role. The problem of stable content of Chinese medicine ingredients is the problem of quality uniformity control of Chinese medicine. How to realize the uniformity control of traditional Chinese medicine in the production process of traditional Chinese medicine is a top priority for pharmaceutical manufacturers. Therefore, it has certain practical significance and economic value to realize a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
CPCG01N30/02G01N2030/027
Inventor 朱明峰杜建强王金钱聂斌王跃生饶毅
Owner JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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