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A method for rapid location of cell nuclei in pathological images

A technology of pathological image and positioning method, which is applied in the field of digital image processing of cell nucleus center positioning in digital pathological images, can solve the problem that the processing speed is difficult to meet the computer-aided analysis of digital pathological full slices, and achieves easy implementation, stable performance, and complex time small effect

Active Publication Date: 2018-08-21
BEIHANG UNIV
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Problems solved by technology

[0005] The present invention is a fast nuclei positioning method for pathological images. Aiming at the problem that the processing speed of the traditional nuclei positioning method is difficult to meet the computer-aided analysis of digital pathological full slices, the digital pathological image can be quickly and accurately positioned without segmenting the nuclei. nuclei in

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  • A method for rapid location of cell nuclei in pathological images
  • A method for rapid location of cell nuclei in pathological images
  • A method for rapid location of cell nuclei in pathological images

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[0016] In order to better understand the technical solutions of the present invention, the present invention will be described in detail below with reference to the accompanying drawings and specific embodiments.

[0017] The present invention is a method for rapidly locating cell nuclei in pathological images, and the method mainly includes the following steps:

[0018] 1. Scan the pathological sections used for tissue biopsy into a computer with a section scanner, and store them as a digital image matrix in the form of RGB three channels.

[0019] 2. Using the color deconvolution matrix, calculate the color deconvolution mapping table.

[0020] 3. Use the color deconvolution mapping table in step 2 to extract the nuclear components in the digital pathological slice to obtain a nuclear component image.

[0021] 4. Perform mixed Gaussian filtering on the image of the cell nucleus components obtained in step 3 to obtain a filtered image.

[0022] 5. Find local maxima in the f...

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Abstract

The invention discloses a quick and stable cell nucleus location method in order to solve the problem that the processing speed of the traditional cell nucleus location algorithm can hardly meet the requirement of large-scale digital pathological full-slice computer-aided analysis. First, a color de-convolution algorithm is used to extract the cell nucleus component in a pathological image; then, the center position of the cell nucleus is highlighted by a mixed Gaussian filter; and finally, the local maximum value is found in the filtered cell nucleus image, and the position of the cell nucleus is determined through adaptive threshold judgment. The method has the advantages of clear process, easy implementation, low time complexity, fast execution and stable location effect, and is of great significance in digital pathological full-slice computer-aided analysis.

Description

technical field [0001] The invention relates to a method for quickly locating cell nucleus in a pathological image, belonging to the field of digital image processing, in particular to a digital image processing technology for locating cell nucleus in a digital pathological image. Background technique [0002] The digital pathological full slide is to convert the pathological slide into a high-magnification large-scale digital image that can be displayed, transmitted and processed by a computer through a special scanning imaging system. In the diagnosis of cancer based on digital pathology whole sections, the morphological characteristics of nuclei and the distribution of different types of nuclei in tissues are the main basis for cancer diagnosis. Accordingly, many computer-aided cancer diagnosis methods start from the precise positioning and segmentation of the nucleus, analyze the characteristics of the tissue in the digital whole section, and carry out the auxiliary diag...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G06T7/00
CPCG06T7/0012G06T2207/10024G06T2207/20024G06T2207/30024
Inventor 姜志国郑钰山张浩鹏麻义兵
Owner BEIHANG UNIV
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