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A composite vitamin ADE oil injection for veterinary use and a preparing method thereof

A technology for multivitamins and injections, which is used in medical preparations, drug combinations, and pharmaceutical formulations containing active ingredients, and can solve the problems of poor antioxidant effect and easy oxidation.

Inactive Publication Date: 2016-07-13
CHONGQING BULL ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the ingredients contained in fat-soluble vitamins are sticky and difficult to dissolve, especially insoluble in water and easily oxidized, general additives such as co-solvents cannot help them dissolve in water to form a clear solution, and the effect of antioxidants is not satisfactory.

Method used

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  • A composite vitamin ADE oil injection for veterinary use and a preparing method thereof
  • A composite vitamin ADE oil injection for veterinary use and a preparing method thereof
  • A composite vitamin ADE oil injection for veterinary use and a preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The veterinary complex vitamin ADE oil injection of the present embodiment, every 100mL injection is made up of following components:

[0026] Vitamin A palmitate 8 million IU;

[0027] Vitamin D 3 400,000 IU;

[0028] Vitamin E acetate 2g;

[0029] Butylated hydroxyanisole 0.02g;

[0030] The balance is oil for injection.

[0031] The preparation method of the veterinary complex vitamin ADE oil injection of the present embodiment may further comprise the steps:

[0032] (1) Accurately weigh the prescribed amount of vitamin E acetate and take the prescribed amount of vitamin D 3 Stir to dissolve, and then stir and mix with the prescribed amount of vitamin A palmitate;

[0033] (2) Heat and dissolve the prescribed amount of butyl hydroxyanisole with a small amount of oil for injection, add it to the mixed solution in step (1), add oil for injection to the full amount, and stir evenly to obtain the complex vitamin ADE oil injection.

Embodiment 2

[0035] The veterinary complex vitamin ADE oil injection of the present embodiment, every 100mL injection is made up of following components:

[0036] Vitamin A palmitate 5 million IU;

[0037] Vitamin D 3 200,000 IU;

[0038] Vitamin E acetate 1g;

[0039] Butylated hydroxyanisole 0.01g;

[0040] The balance is oil for injection.

[0041] The preparation method of the veterinary complex vitamin ADE oil injection of the present embodiment may further comprise the steps:

[0042] (1) Accurately weigh the prescribed amount of vitamin E acetate and take the prescribed amount of vitamin D 3 Stir to dissolve, and then stir and mix with the prescribed amount of vitamin A palmitate;

[0043] (2) Heat and dissolve the prescribed amount of butyl hydroxyanisole with a small amount of oil for injection, add it to the mixed solution in step (1), add oil for injection to the full amount, and stir evenly to obtain the complex vitamin ADE oil injection.

Embodiment 3

[0045] The veterinary complex vitamin ADE oil injection of the present embodiment, every 100mL injection is made up of following components:

[0046] Vitamin A palmitate 15 million IU;

[0047] Vitamin D 3 700,000 IU;

[0048] Vitamin E acetate 4g;

[0049] Butylated hydroxyanisole 0.05g;

[0050] The balance is oil for injection.

[0051] The preparation method of the veterinary complex vitamin ADE oil injection of the present embodiment may further comprise the steps:

[0052] (1) Accurately weigh the prescribed amount of vitamin E acetate and take the prescribed amount of vitamin D 3 Stir to dissolve, and then stir and mix with the prescribed amount of vitamin A palmitate;

[0053] (2) Heat and dissolve the prescribed amount of butyl hydroxyanisole with a small amount of oil for injection, add it to the mixed solution in step (1), add oil for injection to the full amount, and stir evenly to obtain the complex vitamin ADE oil injection.

[0054] For the different batc...

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Abstract

A composite vitamin ADE oil injection for veterinary use and a preparing method thereof are disclosed. Each 100 mL of the injection comprises 5 million IU to 15 million IU of vitamin A palmitate, 100 thousand IU to 800 thousand IU of vitamin D3, 1-5 g of vitamin E acetate and 0.01-0.1 g of butylated hydroxyanisole, with the balance being oil used for injections. In normal shelf life, the injection keeps a clear state and is free of turbidness, layering and other instable phenomena. Lipid-soluble vitamins are prepared into the oil injection that is good in stability, and therefore difficult problems of dissolving the lipid-soluble vitamins and keeping a clear solution state are overcome.

Description

technical field [0001] The invention belongs to the technical field of veterinary drugs, and in particular relates to a veterinary compound vitamin ADE oil injection and a preparation method thereof. Background technique [0002] Vitamins are trace organic compounds necessary to maintain the normal physiological functions of the body. They play an important role in the growth, metabolism, and development of the body. The content of vitamins in the body is small, but they are indispensable. Although the chemical structures and properties of various vitamins are different, they have some things in common: 1. Vitamins are ubiquitous in food; 2. The role of vitamins is mainly to participate in the regulation of body metabolism; Synthesis or insufficient synthesis can not meet the needs of the body and must be obtained from the outside world. [0003] According to the solubility, vitamins are divided into two categories: water-soluble and fat-soluble. Fat-soluble vitamins refer...

Claims

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Application Information

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IPC IPC(8): A61K31/593A61K9/08A61P3/02A61K31/355A61K31/232
Inventor 吴俊伟姜波陈红伟邓开峰
Owner CHONGQING BULL ANIMAL PHARMA
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