Application of hydrogen sulfide and donor of hydrogen sulfide in preparing medicine for treating achalasia of cardia
A technology for achalasia and hydrogen sulfide donor, which is applied in the directions of drug combination, digestive system, pharmaceutical formulation, etc., can solve the problems of poor curative effect, serious adverse reactions, and inability to combine drugs in achalasia, and reduce the number of surgeries. rate, improve dysphagia, reduce side effects
Inactive Publication Date: 2016-07-13
GENERAL HOSPITAL OF TIANJIN MEDICAL UNIV
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Problems solved by technology
[0006] The present invention aims to solve the problems of poor curative effect, serious adverse reactions, and inability to combine medications with existing drugs for treating achalasia, and proposes a use of hydrogen sulfide and its donor in the preparation of drugs for treating achalasia
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[0022] The present invention will be further described below in conjunction with the accompanying drawings and embodiments.
[0023] 1. Expression of esophageal hydrogen sulfide synthase in patients with achalasia and normal subjects
[0024] Twelve achalasia patients who underwent peroral endoscopic myotomy (POEM) were randomly selected as the achalasia group, and 8 patients with esophageal squamous cell carcinoma who underwent esophagectomy were selected as the control group. Patients with achalasia underwent POEM. During POEM, circular muscle specimens were taken under endoscopy. The achalasia group was further divided into: cardia group, LES group, 2cm above LES group, and 4cm above LES group. After esophagectomy in patients with esophageal squamous cell carcinoma, the circular muscle tissue at the LES site was taken as a control, in order to avoid the expression of hydrogen sulfide synthase (cystathionine-β-synthase CBS, cystathionine-γ-lyase CSE) in tumor tissue The spe...
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The invention discloses application of hydrogen sulfide and a donor of hydrogen sulfide in preparing a medicine for treating achalasia of cardia, and belongs to the field of medical preparations containing inorganic effective components. The donor of hydrogen sulfide is an exogenous hydrogen sulfide donor NaSH or GYY4137 and an endogenous hydrogen sulfide donor cysteine, N-acetylcysteine or allicin. Due to the application, problems that conventional medicines are poor in effect of treating achalasia of cardia, are serious in adverse reaction, cannot be used together, and the like can be solved. By adopting the hydrogen sulfide and the donor of the hydrogen sulfide, the symptom that a patient suffering from achalasia of cardia has dysphagia is greatly alleviated, the medicine can be not only independently used, but also used together with conventional treatment medicines, side effect is small, the living quality of patents can be greatly improved, and very great clinical values can be achieved.
Description
technical field [0001] The invention belongs to the field of medical preparations containing inorganic active ingredients, in particular to the use of hydrogen sulfide and its donor in the preparation of medicines for treating achalasia. Background technique [0002] Achalasia is a disease in which the lower esophageal sphincter is insufficient due to esophageal dysfunction caused by neuromuscular dysfunction in the esophageal cardia, and food cannot pass smoothly and stays, thereby gradually reducing esophageal tension, peristalsis, and esophageal dilation. The incidence of achalasia is not high, about 0.3-1.63 / 100,000 people / year, but because the disease does not affect the patient's life expectancy, the prevalence of the disease is not low, and it increases year by year. The main manifestations of patients are dysphagia, aspiration, severe malnutrition, weight loss, and even the occurrence of esophageal cancer due to long-term stimulation of esophageal contents. Because ...
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Login to View More IPC IPC(8): A61K33/04A61K31/255A61K31/198A61P1/00
CPCA61K33/04A61K31/198A61K31/255
Inventor 王邦茂赵威张莉莉郑忠青刘天宇
Owner GENERAL HOSPITAL OF TIANJIN MEDICAL UNIV