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Method for extracting pharmacodynamically active ingredients efficiently from root of Brassica rapa

A medicinal ingredient, the technology of turnip, which is applied in the field of efficient extraction of 4-butyric acid, can solve the problems of low utilization rate of raw materials and low extraction rate, and achieve the effects of improving low efficiency, no pollution of samples, and shortening extraction time

Active Publication Date: 2016-07-13
ANHUI NONGDA BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, as mentioned above, although there are many methods for extracting 4-(2-formyl-5-hydroxymethyl-1-hydro-pyrrol-1-yl)butanoic acid from different plant sources, there is a ubiquitous The problem of low extraction rate and low utilization rate of raw materials

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] A. Prepare materials

[0044] The turnip root is taken, washed with water, dried naturally, dehydrated and dried until the moisture content is less than 1%, crushed and ground, and passed through an 80-mesh sieve to obtain the turnip root powder.

[0045] B. Extraction

[0046] Get 0.1kg of turnip root powder and place it in an industrial microwave extraction kettle, add an aqueous solution of hydrochloric acid at pH=4 to wet the powder (the mass ratio of aqueous hydrochloric acid solution to turnip root powder is 1:9) and stir evenly, and then carry out Microwave radiation pretreatment for 7 minutes, microwave power 220W; after the pretreatment, add 1kg of extractant to it, the type of extractant is shown in Table 1 below, after mixing evenly, add 50g of auxiliary agent lauryl polyoxyethylene (7) ether, Direct microwave extraction at room temperature for 20 minutes, the microwave power is 350W, and then the extract is separated by filtration; after vacuum concentratio...

Embodiment 2

[0056] A. Prepare materials

[0057] The turnip root is taken, washed with water, dried naturally, dehydrated and dried until the water content is less than 2%, crushed and ground, and passed through a 70-mesh sieve to obtain the turnip root powder.

[0058] B. Extraction

[0059] Get 0.1kg of turnip root powder and place it in an industrial microwave extraction kettle, add an aqueous hydrochloric acid solution with pH=3 to wet the powder (the mass ratio of aqueous hydrochloric acid solution to turnip root powder is 1:8) and stir evenly, and then carry out Microwave radiation pretreatment for 7 minutes, microwave power 220W; after the pretreatment, add 1kg of extractant 1-butyl-1-methylpyrrolidine chloride, mix well, then add 60g of additives, the type of additives See Table 2 below. Direct microwave extraction at room temperature for 15 minutes with a microwave power of 350W, and then filter and separate the extract; It was 550W, and the crude product was obtained.

[0060...

Embodiment 3

[0070] A. Prepare materials

[0071] The turnip root is taken, washed with water, dried naturally, dehydrated and dried until the water mass content is less than 1%, crushed and ground, and passed through a 90-mesh sieve to obtain the turnip root powder.

[0072] B. Extraction

[0073] Get 0.1kg of turnip root powder and place it in an industrial microwave extraction kettle, add an aqueous hydrochloric acid solution with pH=5 to wet the powder (the mass ratio of aqueous hydrochloric acid solution to turnip root powder is 1:7) and stir evenly, and then carry out Microwave radiation pretreatment for 7 minutes, microwave power 220W; after pretreatment, add extractant 1-butyl-1-methylpyrrolidine chloride salt, the amount of extractant is shown in Table 3 below, after mixing evenly, add 45g of auxiliary lauryl alcohol polyoxyethylene (7) ether, direct microwave extraction at room temperature for 20min, the microwave power is 350W, and then filter and separate to obtain the extract...

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Abstract

The invention relates to a process for pharmacodynamically active ingredients efficiently from root of Brassica rapa.A pyrrolidine salt is used as an extracting agent, a nonionic surfactant (fatty alcohol-polyoxyethylene ether) is used as an extracting aid, an extracting separating mode combining microwave-assisted extraction and efficient counter-current chromatography, the unique functions of microwave such as plant tissue extracting, electromagnetic heating and microwave shaping and cleaning are given to full play, dissolution rate of a target is effectively increased, and the process has the advantages of high efficiency, high speed, no pollution to samples and the ability to mass separation, extracting yield is greatly increased, and the process has promising industrial application prospect and market prospect.

Description

technical field [0001] The invention belongs to the technical field of extracting effective active ingredients of medicines from natural plants. More specifically, the present invention relates to a process for efficiently extracting 4-(formyl-5-hydroxymethyl-1-hydrogen-pyrrol-1-yl)butyric acid from turnip, which belongs to the natural plant of medicinal active ingredients Extract fields. Background technique [0002] 4-(2-formyl-5-hydroxymethyl-1-hydro-pyrrol-1-yl)butanoic acid is an important active ingredient of medicines, which has many biological activities such as protecting the liver and increasing peripheral blood flow, and has been It is widely used in related fields such as medicine and preparation, and its structure is as follows: [0003] There have been many reports on the extraction of 4-(2-formyl-5-hydroxymethyl-1-hydrogen-pyrrol-1-yl)butyric acid in the prior art, which mainly optimize the extraction process for different plant sources . For example: ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D207/333
CPCC07D207/333
Inventor 司红康
Owner ANHUI NONGDA BIOLOGICAL TECH CO LTD
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