Preparation method of D-p-chlorophenylalanine
A technology of p-chlorophenylalanine and hydrochloric acid is applied in the field of preparation of D-p-chlorophenylalanine, can solve the problems of large reaction volume, increased concentration cost, low solubility and the like, and achieves low cost, simple method, high yield effect
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[0015] A preparation method of D-p-chlorophenylalanine, the method comprises the steps:
[0016] 1. Synthesis of acetylated D, L-p-chlorophenylalanine:
[0017] D,L-p-Chlorophenylalanine, dissolved in water, adjusted pH to 10 with alkali, temperature controlled at 0-5°C, acetic anhydride was added dropwise, pH was controlled with 5N sodium hydroxide during the reaction, and indene was used in the reaction solution The triketone develops color until the amino acid no longer develops color, indicating that all the amino acids are acetylated. Add hydrochloric acid to adjust the pH to 1-2, and a large amount of precipitated product appears. The crystals are collected by filtration, washed with acid water, and dried. The yield is 90%.
[0018] 2. Dissolve the acetylated D,L-p-chlorophenylalanine at 80°C, the concentration can reach 0.7M, add purified L-high temperature acylase, react for 48 hours, and separate by liquid phase detection The degree of deacetylation of D-p-chlorophe...
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