Cytogene translation process modeling method

A translation process, cell gene technology, applied in the field of computer virtual reality, biological information technology, can solve the problem of differences in the degree of modeling refinement, to achieve the effect of reliable performance

Inactive Publication Date: 2016-07-13
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
View PDF4 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Different modeling methods may choose different degrees of abstraction, and the degree of modeling refinement varies

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Cytogene translation process modeling method
  • Cytogene translation process modeling method
  • Cytogene translation process modeling method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0043] The present invention will be further described in detail below in conjunction with the examples.

[0044] The invention comprises the following steps: the abstraction of the biological process of gene translation; the mathematical modeling of related biological problems; and the fitting of biochemical reaction parameters with experimental data for related models.

[0045] According to the abstraction of the biological process of gene expression, several key reaction steps of gene expression are obtained. The process of ribosomal translation of mRNA is divided into three steps: initialization, extension, and termination, among which the initialization process has been simplified a lot. The whole process is marked by the state position of the ribosome. For example, the initialization process means that the ribosome is bound to the start site of the mRNA by discrete size subunits; at this time, the position mark of the ribosome becomes By analogy, when extending to site...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a cytogene translation process modeling method. The cytogene translation process modeling method comprises the following steps: tracking a state of each mRNA (Messenger Ribonucleic Acid) molecule and updating a count in real time to obtain the quantity of mRNAs which can be initialized among various mRNAs; tracking a state of each ribosomal molecule and updating a count in real time to obtain the quantity of ribosomes which can be moved on various mRNA sites; calculating a total initialization speed of the mRNA molecules; calculating a total extension speed of the ribosomal molecules on the corresponding mRNAs; obtaining a total probability of mRNA initialization and ribosome extension according to the total initialization speed and the total extension speed; randomly selecting an event according to the weight of an event probability to carry out a response; after the response is ended, updating a cell state. According to the cytogene translation process modeling method disclosed by the invention, the possibility of error translation is considered while a correct translation is considered by adopting a principle based on a totally asymmetric simple repulsion process and by considering the half-life period of molecules at the same time, such that the translation process is closer to the essence of the biological problem.

Description

technical field [0001] The invention relates to a method for modeling a gene translation process, which belongs to biological information technology, calculation method and computer virtual reality technology. Background technique [0002] Many basic life phenomena such as cell metabolism, growth and differentiation are regulated by intracellular genes, and the regulation of genes is realized through their corresponding protein products. As one of the most basic and critical reactions in cells, more and more experimental evidence shows that protein translation plays a key regulatory role in the normal function of genes in cells. The translation of proteins in cells is generally divided into three main steps: initiation, elongation and termination. The key substance responsible for gene translation is the ribosome: [0003] Ribosomes are composed of two subunits, one large and one small, each of which has a special structure for molecules such as peptide chains, mRNA, tRNA ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): G06F19/12
Inventor 李国辉张鼎林
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap