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Fractional flow reserve (FFR) index with adaptive boundary condition parameters

A technology of boundary conditions and indicators, applied in blood flow measurement, electrical digital data processing, instruments used for radiological diagnosis, etc., can solve the problems of non-constant resistance, estimation error, affecting FFR, etc.

Active Publication Date: 2016-07-13
KONINKLJIJKE PHILIPS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in reality, this resistance is not constant, and it affects the FFR
Therefore, this method may cause estimation error

Method used

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  • Fractional flow reserve (FFR) index with adaptive boundary condition parameters
  • Fractional flow reserve (FFR) index with adaptive boundary condition parameters
  • Fractional flow reserve (FFR) index with adaptive boundary condition parameters

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Embodiment Construction

[0014] An iterative method for determining the FFR metric is described below. The method involves first assuming that all vessels are healthy, and using CFD simulation with resistance boundary condition estimation to determine the FFR index. Next, the resistance boundary condition is iteratively corrected according to the severity of stenosis estimated by the FFR index from the previous iteration. Subsequent FFR metrics are then determined based on the corrected boundary conditions. The iterative process of correcting the resistance boundary conditions and computing another FFR metric continues until the stopping criterion is satisfied. Then output the final FFR index.

[0015] figure 1 An imaging system 100 such as a CT scanner is schematically illustrated. Imaging system 100 includes a generally fixed gantry 102 and a rotating gantry 104 rotatably supported by fixed gantry 102 and rotating about an examination region 106 about a z-axis. A subject support 108 , such as a...

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Abstract

A method includes obtaining a boundary condition estimate. The boundary condition estimate includes at least an estimated outlet resistance of a vessel with a stenosis. The method further includes correcting the boundary condition estimate based on a severity of the stenosis, thereby creating a corrected boundary condition. The method further includes determining an FFR index based on the corrected boundary condition. The method further includes displaying the FFR index. A computing system (122) includes a computer readable storage medium (126) with instructions (124) that iteratively determine at least an FFR index based on a severity of a stenosis of a vessel. The computing system further includes a computer processor (120) that processes the instructions and generates the FFR index based on the severity of the stenosis of the vessel.

Description

technical field [0001] The following relates generally to fractional flow reserve (FFR) metrics and more specifically to the use of adaptive boundary conditions to determine FFR metrics, and is described with a specific application to computed tomography (CT). However, the following also applies to other imaging modalities, including X-ray, Magnetic Resonance Imaging (MRI), and / or other imaging modalities. Background technique [0002] The FFR index is an indicator of the functional severity of coronary stenosis, which is calculated from pressure measurements taken during coronary angiography and is defined as the distal relative to the proximal (near the orifice) pressure under hyperemic conditions (narrow back) blood pressure. That is, the FFR index expresses the maximum flow along a blood vessel in the presence of a stenosis as compared to the maximum flow assuming no stenosis. FFR values ​​are absolute numbers between 0 and 1, where a value of 0.50 indicates that a giv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/02A61B6/00G06F19/00
CPCA61B6/5217A61B5/02007A61B6/032A61B5/026A61B5/055G16H50/50A61B6/504G16H50/30A61B6/03
Inventor G·吉勒博阿Y·拉马什L·戈申
Owner KONINKLJIJKE PHILIPS NV