A method of using pdcl2 (cod) to synthesize pharmaceutical intermediate phenanthrene compounds

A compound and catalyst technology, which is applied in the direction of hydrocarbons, hydrocarbons, carbon compound catalysts, etc., can solve the problems of insufficient utilization of raw materials, low production efficiency, and inability to meet production needs, and achieve broad industrial application prospects and high yields Effect
CN105801337BActive Publication Date: 2018-08-14上海芃蒎生物科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
上海芃蒎生物科技有限公司
Publication Date
2018-08-14

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Abstract

The invention relates to a method for synthesizing a phenanthrene compound shown in the formula (I) in the specification from (1,5-cyclooctadiene) palladium chloride. The method comprises steps as follows: a compound in the formula (II) and a compound in the formula (III) are subjected to a reaction in a solvent in an inert atmosphere in the presence of a catalyst containing (1,5-cyclooctadiene) palladium chloride, an organic ligand and alkali, and the compound in the formula (I) in the specification is obtained, wherein each of R1 and R2 is independently H, C1-C6 alkyl groups, C1-C6 alkoxy groups or halogens, R3 is C6-C10 aryl groups or C5-C8 heteroaryl, C6-C10 aryl groups or C4-C8 heteroaryl are optionally substituted by 1-3 substituent groups, and the substituent groups are C1-C6 alkyl groups or halogens. The method has a good effect through proper selection of the catalyst, the organic ligand, alkali and the solvent and has wide industrial application prospect.
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Description

[0001] The application of the present invention is a divisional application of the application number 201510100568.5 (a method for synthesizing pharmaceutical intermediate phenanthrene compounds) filed on March 6, 2015. technical field

[0002] The invention relates to a method for synthesizing condensed ring compounds, more specifically to a method for synthesizing a pharmaceutical intermediate phenanthrene compound, and belongs to the fields of organic synthesis and pharmaceutical intermediate synthesis. Background technique

[0003] Fused ring compounds such as naphthalene, anthracene, phenanthrene and other compounds have attracted the attention and attention of pharmaceutical researchers due to their ubiquitous biological activities. Among them, phenanthrene and its derivatives are an important class of aromatic compounds, which have been widely used in the fields of drug design and synthesis, and material research and development.

[0004] It is precisely because of su...

Claims

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