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Application of monodisperse polymeric silica gel in the purification of rg1, re and rb1

A technology of polymerized silica gel and monodisperse, applied in the field of pharmaceutical invention, can solve the problem of low purity of ginsenoside Rb1, and achieve the effect of extremely low toxicity

Active Publication Date: 2018-12-18
GUANGXI WUZHOU PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Aiming at the problem that the purity of the existing ginsenoside Rg1, ginsenoside Re and ginsenoside Rb1 is not high, the inventor finally proposed the present invention after extensive research

Method used

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  • Application of monodisperse polymeric silica gel in the purification of rg1, re and rb1
  • Application of monodisperse polymeric silica gel in the purification of rg1, re and rb1
  • Application of monodisperse polymeric silica gel in the purification of rg1, re and rb1

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1: the preparation method of Panax notoginseng saponins

[0037] Take 1000g of Panax notoginseng medicinal material, add 60% ethanol 5 times the weight of Panax notoginseng, heat and reflux at 60°C to extract twice, the first time is 3 hours, the second time is 2 hours, the extracts are combined, filtered, and the filtrate is concentrated to a relative density of 1.20, After degreasing the concentrated solution, the obtained extract is adsorbed and eluted by D101 macroporous adsorption resin, and the eluate is adsorbed and decolorized by alumina and activated carbon, then concentrated and dried to obtain total saponins of Panax notoginseng.

Embodiment 2

[0038] Embodiment 2: the preparation method of Panax notoginseng saponins

[0039] Take notoginseng and grind it into coarse powder 1000g, add 80% ethanol 8000ml to extract for 7 hours, collect the extract, filter, take the filtrate to recover ethanol until it has no alcohol smell, add water to make a solution containing 0.5g of crude drug per 1ml, pass through a macroporous resin column and alumina adsorption, eluting with 65% ethanol, concentrating and drying the eluent to obtain total saponins of Panax notoginseng.

Embodiment 3

[0040] Embodiment 3: the preparation method of Panax notoginseng saponins

[0041] Take Panax notoginseng, make 20 mesh coarse powder, extract 2 times with ethanol, add 10 times of 70% ethanol each time, extract 3 hours each time, combine the extracts, filter, take the filtrate to recover ethanol until it has no alcohol smell, pass Adsorb on a macroporous adsorption resin column with 8 times the weight of Panax notoginseng, collect the eluent, absorb and decolorize, recover the solvent, concentrate, and dry at low temperature to obtain the total saponins of Panax notoginseng.

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Abstract

The invention relates to an application of monodispersed polysilica gel to purification of Rg1, Re and Rb1. High-degree separation and purification of Rg1, Re and Rb1 from Panax notoginsenosides are carried out mainly by using monodispersed polysilica gel in purification of Rg1, Re and Rb1.

Description

technical field [0001] The invention relates to the field of medical inventions, in particular to the use of monodisperse polymerized silica gel in the purification of ginsenoside Rg1, ginsenoside Re and ginsenoside Rb1. Background technique [0002] Panax notoginseng total saponins are derived from Panax notoginseng medicinal materials, and the main components include notoginseng saponin R1, ginsenoside Rg1, ginsenoside Re, ginsenoside Rb1 and ginsenoside Rd. It is often used for promoting blood circulation and removing blood stasis, dredging channels and collaterals, and has pharmacological effects on hyperlipidemia, hyperviscosity, and hypertension. In clinical practice, the whole ingredients are mainly prepared into preparations, and there is no single ingredient or combination preparations. [0003] It has preventive and therapeutic effects on cardiovascular and cerebrovascular diseases. Patent application CN101116669 discloses adjuvant drugs for preventing leukopenia...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J17/00
Inventor 兰星李钊文黄宇声徐卓张栩颜
Owner GUANGXI WUZHOU PHARMA GRP