Tyrosine hydroxylase inhibitor for treating intestinal hyperpermeability
A tyrosine hydroxylase inhibitor, a technology of tyrosine hydroxylase, which is applied in the directions of non-central analgesics, anhydride/acid/halide active ingredients, and non-active ingredients medical preparations, etc. Proven safe and effective
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[0042] Initially 200 patients were screened. Thirty subjects who met the study criteria consented. Nine (9) subjects had high blood sugar levels (hyperglycemia) prior to consent to the study.
[0043]High blood glucose levels (hyperglycemia) were defined as fasting plasma glucose levels of 126 mg / dl or greater on two separate occasions. The mean patient age was 62 years, and the median patient age was 60 years. Six patients were female and three patients were male. Five patients were 50-60 years old, and 4 patients were over 60 years old.
[0044] Patients in the study were administered drugs including tyrosine hydroxylase inhibitors (i.e., α-methyl-DL tyrosine), melanin boosters (i.e., melanotan II), p450 3A4 boosters (i.e., 5 , 5-diphenylhydantoin) and leucine aminopeptidase inhibitors (ie, N-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutyryl]-L- leucine) treatment options. The compounds were administered each of 5 days per week for a period of 6 weeks with 1 or 2 days of rest...
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