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Application of sharpleaf galangal fruit extract to preparation of medicines for treating inflammatory bowel diseases

A technology of extract and Yizhiren, which is applied in the field of medicine, can solve the problems of whether inflammatory bowel disease is effective and its mechanism has not been reported.

Inactive Publication Date: 2016-08-17
刘嫱
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, there is no report on whether it is effective and its mechanism alone in inflammatory bowel disease

Method used

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  • Application of sharpleaf galangal fruit extract to preparation of medicines for treating inflammatory bowel diseases
  • Application of sharpleaf galangal fruit extract to preparation of medicines for treating inflammatory bowel diseases
  • Application of sharpleaf galangal fruit extract to preparation of medicines for treating inflammatory bowel diseases

Examples

Experimental program
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Effect test

Embodiment 1

[0030] (1) Extraction of Yizhi Kernel Extract

[0031] Get Yizhiren 1.5kg, pulverize, cross 10 mesh sieves, put in a 10L round bottom flask, add 70% ethanol 9L to reflux and extract twice, each 1h, wherein the mass volume ratio of said Yizhiren and ethanol is (g / ml) was 1:6, filtered through gauze, combined the two filtrates, recovered the solvent under reduced pressure below 60°C, and obtained 108g of the alcoholic extract of Alpinia japonicus. Take by weighing 20g alcohol extract extract from extracted extract in 500ml beaker, then add water 200ml in beaker, wherein the mass volume ratio of said alcohol extract extract and water is (g / ml) is 1: 10. Stir with a glass rod to form an emulsion, then add the emulsion into a 1L separatory funnel through a funnel, sequentially extract with petroleum ether, chloroform, n-butanol, and ethyl acetate, and repeat this operation until 108g of immersion The cream is all extracted. The solvents were recovered and dried under reduced pre...

Embodiment 2

[0035] (1) Extraction of Yizhi Kernel Extract

[0036] Get Yizhiren 1.5kg, pulverize, cross a 10-mesh sieve, put in a 10L round bottom flask, add 4.5L of 70% ethanol to reflux and extract twice, each time for 1.5h, wherein the mass volume ratio of the Yizhiren and ethanol is (g / ml) was 1:3, filtered through gauze, combined the two filtrates, recovered the solvent under reduced pressure below 45°C, and obtained 100g of the alcoholic extract of P. Take by weighing 20g alcohol extract extract from extracted extract in 500ml beaker, then add water 200ml in beaker, wherein the mass volume ratio of said alcohol extract extract and water is (g / ml) is 1: 10. Stir with a glass rod to form an emulsion, then add the emulsion into a 1L separatory funnel through a funnel, extract with petroleum ether, chloroform, ethyl acetate, and n-butanol in sequence, and repeat this operation until 100g of The cream is all extracted. The solvents were recovered and dried under reduced pressure to obt...

Embodiment 3

[0040] (1) Extraction of Yizhi Kernel Extract

[0041] Get Yizhiren 1.5kg, pulverize, cross 10 mesh sieves, put in a 10L round bottom flask, add 70% ethanol 15L to reflux and extract twice, each 0.5h, wherein the mass volume ratio of said Yizhiren and ethanol is ( g / ml) was 1:10, filtered through gauze, combined the two filtrates, recovered the solvent under reduced pressure below 75°C, and obtained 106g of the alcoholic extract of Alpinia japonicus. Take by weighing 20g alcohol extract extract from extracted extract in 500ml beaker, then add water 200ml in beaker, wherein the mass volume ratio of said alcohol extract extract and water is (g / ml) is 1: 10. Stir with a glass rod to form an emulsion, then add the emulsion into a 1L separatory funnel through a funnel, sequentially extract with petroleum ether, chloroform, n-butanol, and ethyl acetate, and repeat this operation until 106g of The cream is all extracted. The solvents were recovered and dried under reduced pressure ...

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Abstract

The invention discloses an application of a sharpleaf galangal fruit extract to preparation of medicines for treating inflammatory bowel diseases, belonging to the field of medicines. An extraction method of the sharpleaf galangal fruit extract comprises the following steps: extracting the sharpleaf galangal fruit extract; and preparing each part of the sharpleaf galangal fruit alcohol extract to obtain the liquid of each part of the sharpleaf galangal fruit alcohol extract. The sharpleaf galangal fruit extract has certain curative effects on inflammatory bowel diseases and has treatment effects similar to the treatment effects of sulfasalazine.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of an extract of yizhiren in the preparation of medicine for treating inflammatory bowel disease. Background technique [0002] Yizhiren is the dry and mature fruit of Zingiberaceae plant Yizhi. It is mainly produced in Hainan and Guangdong. It likes warm and humid climates and grows in damp places under forests. Since ancient times, Yizhiren has been a commonly used medicinal material in TCM clinics. It has been recorded in many classical monographs on medicinal materials in my country. The environment for the growth of tropical medicinal plants in Hainan Island is extremely superior. Compared with other islands, the quality of Yizhi medicinal materials is obviously superior. [0003] Kuho M et al. reported that 50% ethanol extract of Yizhiren had anti-ulcer effect (Feng Shuxiang, Liu Yaoming, Dong Junxing. The progress of the chemical composition and pharmacological rese...

Claims

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Application Information

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IPC IPC(8): A61K36/9062A61K47/26A61P1/00
CPCA61K36/9062A61K47/26A61K2236/333A61K2236/39A61K2236/51
Inventor 刘嫱房磊臣谢毅强韦祎零小妹刘一鸣高新征
Owner 刘嫱
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