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Method for preparing traditional Chinese medicinal super-micro granule preparation for treating intestinal diseases of livestock and poultry

An intestinal disease, ultrafine powder technology, applied in antiviral agents, medical raw materials derived from angiosperm subphylum, antibacterial drugs, etc. , to achieve the effect of improving drug palatability, small particle size, and conducive to preservation

Inactive Publication Date: 2016-08-24
SHENYANG VICA ANIMAL HUSBANDRY TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the problems of drug residues and drug resistance that may be caused by antibiotics and chemically synthesized drugs, as well as the problems of large dosage and high cost of traditional Chinese medicine powders, and the inability to fully exert the drug effect, the present invention provides a natural, drug-free, and drug-free Preparation method of traditional Chinese medicine Andrographis paniculata superfine powder granule with significant control effect on intestinal diseases of livestock and poultry with side effects, dosage reduction and good curative effect

Method used

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  • Method for preparing traditional Chinese medicinal super-micro granule preparation for treating intestinal diseases of livestock and poultry
  • Method for preparing traditional Chinese medicinal super-micro granule preparation for treating intestinal diseases of livestock and poultry
  • Method for preparing traditional Chinese medicinal super-micro granule preparation for treating intestinal diseases of livestock and poultry

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: Get 5000g of Andrographis paniculata medicinal material decoction pieces, be ground into 100 mesh fine powder, pulverize again through superfine pulverizer, to 300 mesh sieve passing rate ≥ 95%, make Andrographis paniculata superfine powder; This superfine powder is placed in mixer , add 4700g of powdered sugar, 300g of flavoring agent, after mixing evenly, add an appropriate amount of 70% ethanol soft material, after the soft material is qualified, extrude and granulate through a swinging granulator (12-14 mesh), after drying, the whole Granules, packaging, inspection, that is, granular products.

[0017] Demonstration of clinical effect:

example 1

[0018] Example 1: Comparative test on the dissolution of active ingredients in Andrographis paniculata superfine powder granules and fine powder

[0019] Test unit: Shenyang Weijia Animal Husbandry Technology Co., Ltd.

[0020] Test drug: Andrographis paniculata superfine powder granule, Andrographis paniculata fine powder in the present invention

[0021] Test method: Accurately weigh 3 parts each of the same amount of superfine powder of Andrographis paniculata and fine powder of Andrographis paniculata, and dilute to volume with 40% methanol solution of the same amount respectively. Use the ZRS-8G intelligent dissolution apparatus to take 1ml of samples at 5, 10, 20, 30, 40, 50, 60, 80, 100, 120, and 140 minutes, and perform decolorization and degreasing with appropriate amount of petroleum ether, SPE column purification, and drying. Afterwards, dissolve and centrifuge with the mobile phase, and take the supernatant as the test sample. Agilent 1260 HPLC was used to determ...

example 2

[0029] Example 2: Clinical Trial for the Treatment of Pullorum

[0030] Test unit: Shenyang Weijia Animal Husbandry Technology Co., Ltd.

[0031] Test animals: 7-day-old healthy chicks

[0032] Test drug: Andrographis paniculata superfine powder granules

[0033] Comparative drug: Chuanxinlian powder

[0034] Test method: The test is divided into 5 groups, 50 chickens in each group, and the drug treatment and experimental treatment of chickens in each group are as follows in Table 1.

[0035] Table 1 Grouping of experimental chickens, drug treatment and experimental treatment

[0036]

[0037] Note: ① The percentages in the table are percentages by weight.

[0038] ② Adding 2% superfine powder particles is equivalent to 1% crude drug, and adding 4% superfine powder particles is equivalent to 2% crude drug.

[0039] After grouping, the chickens were challenged with Salmonella pullorum clinically isolated and identified, and diagnosed as pullorum according to the conditi...

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Abstract

The invention discloses a method for preparing a traditional Chinese medicinal super-micro granule preparation for treating intestinal diseases of livestock and poultry. The method is characterized in that the granule preparation is prepared by adding a proper amount of auxiliaries into traditional Chinese medicine herba andrographitis super-micro powder, wherein the herba andrographitis is a purely natural traditional Chinese medicinal material, is wide and sufficient in resource, easy to prepare and low in cost, and is subjected to superfine grinding to prepare granules for mixing or irrigating administration, and a relatively good curative effect for diarrhea diseases of livestock and poultry can be achieved. Compared with a current common medicine, the super-micro granule preparation has the advantages of high safety, good curative effect, no residue and the like, ensures animal-source food safety and human body health, and is a good product for treating intestinal diseases of livestock and poultry.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, and relates to a traditional Chinese medicine superfine powder granule preparation, in particular to a preparation method of a traditional Chinese medicine superfine powder granule for treating intestinal diseases of livestock and poultry. Background technique [0002] Enteric diseases of livestock and poultry mainly refer to intestinal infectious diseases of livestock and poultry, among which intestinal diseases caused by bacteria and viruses are particularly serious, such as poultry colibacillosis, pullorum, fowl typhoid, pullorum of piglets, yellow diarrhea of ​​piglets, swine enteritis, etc. . Diarrhea is the main symptom of these common and frequently occurring infectious diseases. After the onset, it affects animal feed intake, feed conversion rate, production capacity and quality of livestock and poultry products. In severe cases, it even causes a large number of deaths and brings huge l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/19A61K9/16A61P1/00A61P31/04A61P31/12A61P1/12
CPCY02A40/70
Inventor 田凯王洪礼赵宝凯虞正伟何凤艳
Owner SHENYANG VICA ANIMAL HUSBANDRY TECH
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