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Beclomethasone dipropionate pharmaceutical composition and application thereof in biological medicines

A technology of beclomethasone dipropionate and its composition, which is applied in the field of biomedicine, can solve the problems that have not yet been reported related to beclomethasone dipropionate, and achieve the effect of improving the hypoglycemic effect

Inactive Publication Date: 2016-08-31
陈斌
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] So far, there has been no report on the correlation between beclomethasone dipropionate and its pharmaceutical composition and diabetes

Method used

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  • Beclomethasone dipropionate pharmaceutical composition and application thereof in biological medicines
  • Beclomethasone dipropionate pharmaceutical composition and application thereof in biological medicines
  • Beclomethasone dipropionate pharmaceutical composition and application thereof in biological medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0021] Separation method: (a) Grind the dried tubers (2kg) of Alisma alisma, extract with 70% ethanol under hot reflux (15L×3 times), combine the extracts, concentrate until no alcohol smell (3L), and then use petroleum ether (3L ×3 times), ethyl acetate (3L×3 times) and water-saturated n-butanol (3L×3 times) were extracted to obtain petroleum ether extract, ethyl acetate extract and n-butanol extract respectively; (b) In the step (a), the ethyl acetate extract was removed with a D101 macroporous resin, and 9 column volumes were eluted with 20% ethanol, and then 10 column volumes were eluted with 65% ethanol, and the 65% eluent was collected. Concentrate under reduced pressure to obtain 65% ethanol elution concentrate; (c) 65% ethanol elution concentrate in step (b) is separated with normal phase silica gel, and the volume ratio is 65:1 (9 column volumes), 35: The dichloromethane-methanol gradi...

Embodiment 2

[0025] Embodiment 2: pharmacological action

[0026] 1. Materials and methods

[0027] 1.1 Materials and Instruments

[0028]Healthy male ICR mice, animal experiment center of Shenyang Medical College, weighing 18-22 g; beclomethasone dipropionate was purchased from China Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the preparation method is shown in Example 1. Streptozotocin (STZ) Sigma Chemical Company of the United States, made 1% STZ solution with citric acid buffer before use; other reagents were of domestic analytical grade. SW-CJ-2FD ultra-clean workbench Suzhou Purification Equipment Co., Ltd.; QYC-2112 large-scale double-layer full-temperature culture shaker Shanghai Tiancheng Experimental Instrument Manufacturing Co., Ltd.; SHY-2A dual-function water bath constant temperature oscillator Jiangsu Dongpeng Instrument Manufacturing Co., Ltd. ; TGL20W desktop high-speed refrigerated centrifuge Hunan Xiangyi Laborat...

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Abstract

The invention discloses a beclomethasone dipropionate pharmaceutical composition and an application thereof in biological medicines; the beclomethasone dipropionate pharmaceutical composition provided by the invention contains beclomethasone dipropionate and a natural product compound (I) having a novel structure and separated from dried tubers of alisma orientalis; the composition of the beclomethasone dipropionate and the compound (I) can significantly improve the sugar tolerance amount of diabetic model mice, inhibits alpha-glucosidase activity, and also improves the ability of the diabetic model mice to resist oxidative injury. The activity of the composition of the beclomethasone dipropionate and the compound (I) is stronger than single activity of the beclomethasone dipropionate or the compound (I); and the composition can be developed into a drug for treating diabetes, and has prominent substantive characteristics and obvious progress compared with the prior art.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of beclomethasone dipropionate, in particular to a pharmaceutical composition of beclomethasone dipropionate and its application in biomedicine. Background technique [0002] The chemical name of beclomethasone dipropionate is 16β-methyl-11β,17α,21-trihydroxy-9α-chloropregna-1,4-diene-3,20-dione-17,21-dipropionate . [0003] Beclomethasone dipropionate is a powerful external glucocorticoid drug, which has anti-inflammatory, anti-allergic and antipruritic effects, can inhibit bronchial exudate, eliminate bronchial mucosal swelling, and relieve bronchospasm. It has a stronger effect on skin vasoconstriction than hydrocortisone. The local anti-inflammatory effect is 5 times that of Fucaolin and Triamcinolone. Strong lipophilicity, easy to penetrate, it will take effect 30 minutes after applying to the affected area. There is no significant effect on body temperature and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/92A61K31/573A61P3/10A61K31/343
CPCA61K31/343A61K31/573C07D307/92A61K2300/00
Inventor 陈斌
Owner 陈斌
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