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Application of simiarenol

A technology of sago cuckoo alcohol and upper respiratory tract, which is applied in the field of medicine and can solve problems that have not yet been discovered

Active Publication Date: 2016-09-21
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, no reports involving sagodrugol in the treatment of upper respiratory tract infection have been found

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1: Experimental research on the antiviral effect of sagocurol in vitro

[0026] 1. Experimental materials

[0027] 1.1 Drugs

[0028] Rhododendron sago alcohol, with a purity of 91.15%, is extracted and purified from Artemisia argyi leaves, provided by Jiangsu Kangyuan Pharmaceutical Co., Ltd.;

[0029] Ribavirin: Shandong Sunlu Pharmaceutical Co., Ltd.

[0030] 1.2 Materials

[0031] Virus species: Influenza virus FM1 strain was provided by the Institute of Medical Biotechnology, Chinese Academy of Medical Sciences, passaged in MDCK dog kidney cells, and its titer was determined by lesions and chicken red blood cell hemagglutination; rhinovirus R14 was provided by the Virus Institute, Chinese Academy of Medical Sciences , passaged in KMB17 diploid cells, and measured; respiratory syncytial virus was purchased from the Institute of Virology, Chinese Academy of Preventive Medicine, and was RSV-N3 strain, amplified on Hep-2 cells, and measured; adenovirus type ...

Embodiment 2

[0048] Embodiment 2: Experimental research on the antibacterial effect of sago azalea alcohol in vitro

[0049] 1. Experimental materials

[0050] 1.1 Drugs

[0051] Rhododendron sago alcohol, with a purity of 91.15%, is extracted and purified from Artemisia argyi leaves, provided by Jiangsu Kangyuan Pharmaceutical Co., Ltd.;

[0052] Ciprofloxacin hydrochloride, Jiangjing New Pharmaceutical Co., Ltd.

[0053] 1.2 Materials

[0054] Standard strains: Staphylococcus aureus, Escherichia coli, Shigella, and Streptococcus beta were identified and provided by the Microbiological Reagent Factory of the Jiangsu Provincial Center for Disease Control and Prevention.

[0055] Clinical isolates: Staphylococcus aureus, Escherichia coli, Acinetobacter, Klebsiella pneumoniae, Staphylococcus epidermidis, and Staphylococcus hominis were provided by the isolation and identification of the Microbiology Department of Jiangsu Provincial People's Hospital.

[0056] Nutrient broth, Shanghai Zho...

Embodiment 3

[0066] Example 3: Experimental research on the mouse model of upper respiratory tract infection caused by sago cuckoo alcohol on influenza A virus

[0067] 1. Experimental materials

[0068] 1.1 Drugs

[0069] Rhododendron sago alcohol, with a purity of 91.15%, is extracted and purified from Artemisia argyi leaves, provided by Jiangsu Kangyuan Pharmaceutical Co., Ltd.;

[0070] Ribavirin: Shandong Sunlu Pharmaceutical Co., Ltd.

[0071] 1.2 Materials

[0072] AL104 electronic balance, Mettler-Toledo Instrument Co., Ltd.;

[0073] Centrifuge, Eppendorf 5424;

[0074] Microplate reader, molecular devices spectrumMax M2e;

[0075] Chicken embryo (9 days old), Nanjing Zhongmu Pharmaceutical Equipment Factory;

[0076] Mouse TNF-α test kit, Shanghai Yuanye Biotechnology Co., Ltd.;

[0077] Influenza A virus A / PR8 / 34 (H1N1), provided by the Institute of Virology, Chinese Academy of Preventive Medicine.

[0078] Animals: 90 ICR mice, male, weighing 13-16 g, purchased from Bei...

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Abstract

The invention provides an application of simiarenol in preparation of drugs for treatment of upper respiratory tract infection. Experiments prove that simiarenol has a certain inhibition effect on both respiratory tract infection related viruses and bacteria and also reduces the lung index, the TNF-alpha content, nasal mucosa inflammatory cell number and the nasopharyngeal lavage liquid colony number of mice with upper respiratory tract infection, and indicate that simiarenol has an obvious anti upper respiratory tract infection effect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a use of sagodactyl alcohol. Background technique [0002] Upper respiratory tract infection, referred to as upper flu, is a general term for inflammation of the nasal cavity, pharynx, and throat respiratory mucosa, including the common cold, acute sinusitis, acute otitis media, etc. The clinical manifestations are fever, headache, nasal congestion, sore throat, cough, etc. It is characterized by nasal edema and pharyngeal mucosa congestion. It is one of the most common infectious diseases in humans. It is prone to complications and involves adjacent organs, such as trachea, bronchi, ears, eyes, and cervical lymph nodes. If it is not treated in time, it will develop Become lower respiratory tract inflammation, is the first cause of death of children under 5 years old. [0003] Upper respiratory tract infection is mainly caused by viral infection, such as rhinovirus,...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61P11/00A61P31/04A61P31/12
CPCA61K31/56A61K36/282Y02A50/30
Inventor 萧伟王俨如张新庄李娜曹亮丁岗王振中
Owner JIANGSU KANION PHARMA CO LTD
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