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Mammary-cancer-susceptible-gene detection chip and preparation method thereof

A detection chip and breast cancer technology, which is applied in the field of breast cancer detection, can solve the problems of high accuracy of inspection and diagnosis, and achieve the effect of high cost performance, high practicability, and high accuracy rate

Inactive Publication Date: 2016-09-28
深圳市核子基因科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In view of this, the purpose of the present invention is to provide a breast cancer susceptibility gene detection chip and its preparation method, which can solve the technical problem of high accuracy of inspection and diagnosis

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  • Mammary-cancer-susceptible-gene detection chip and preparation method thereof
  • Mammary-cancer-susceptible-gene detection chip and preparation method thereof
  • Mammary-cancer-susceptible-gene detection chip and preparation method thereof

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Embodiment Construction

[0039] In order to further understand the present invention, the preferred embodiments of the present invention are described below in conjunction with the examples, but it should be understood that these descriptions are only for further illustrating the features and advantages of the present invention rather than limiting the patent requirements of the present invention.

[0040] A breast cancer susceptibility gene detection chip provided by the present invention includes a solid support and gene detection probes fixed on the fixed support; the gene detection probes include 31 of the 24 breast cancer susceptibility genes SNP site; 24 breast cancer susceptibility genes are CHEK2, PALB2, ZNF350, ESR1, C6orf97, USP7, MRPS30, AURKA, ATM, CASC16, TOX3, DNMT1, ZMIZ1, TGFB1, FGFR2, ZNF365, SLC4A7, TNRC9 , TNP1, HER2, BRCA2, CCDC170, BRCA1, CYP11A1;

[0041] The SNP site of CHEK2 is rs17879961;

[0042] The SNP sites of the PALB2 are rs249954, rs120963 and rs16940342;

[0043] The...

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Abstract

The invention discloses a mammary-cancer-susceptible-gene detection chip which comprises a solid support and a gene detection probe fixed onto the solid support. The gene detection probe comprises 31 SNP (single-nucleotide polymorphism) loci of 24 mammary-cancer-susceptible genes. The 24 mammary-cancer-susceptible genes are respectively CHEK2, PALB2, ZNF350, ESR1, C6orf97, USP7, MRPS30, AURKA, ATM, CASC16, TOX3, DNMT1, ZMIZ1, TGFB1, FGFR2, ZNF365, SLC4A7, TNRC9, TNP1, HER2, BRCA2, CCDC170, BRCA1 and CYP11A1. The gene detection probe comprises the 31 SNP loci of the 24 mammary-cancer-susceptible genes. The documents prove that the loci have higher practicality, can be used for large-scale screening of early diagnosis of diseases, have the advantages of high detection success rate, favorable technique reproducibility and high cost performance, and provide important references for diagnosis, typing and prognosis of mammary cancer, thereby implementing early diagnosis of diseases.

Description

technical field [0001] The invention relates to the field of breast cancer detection, in particular to a breast cancer susceptibility gene detection chip and a preparation method thereof. Background technique [0002] Early detection and systematic evaluation of multiple genetic markers associated with common diseases will contribute to early prevention, diagnosis and treatment of diseases. At present, studies have discovered a large number of genetic markers associated with various common diseases. However, due to the lack of sufficient sensitivity and extensive (high-throughput detection sites, high-throughput detection samples) screening for multiple disease-related markers The methods of investigation and testing make the genetic markers of these common diseases unable to be widely used. In addition, the current lack of systematic and effective integration of genetic markers of common diseases has greatly restricted the development of early prevention, diagnosis and tre...

Claims

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Application Information

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IPC IPC(8): C12Q1/68C40B40/06
CPCC12Q1/6886C12Q1/6837C12Q2600/112C12Q2600/118C12Q2600/156C12Q2565/501C12Q2525/10C12Q2521/525
Inventor 张核子
Owner 深圳市核子基因科技有限公司
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