The invention discloses an SNP marker for detecting nasopharyngeal cancer susceptibility. The SNP marker comprises 21 SNP loci: rs9344, rs13347, rs1412829, rs9418990, rs915906, rs8192780, rs3827688, rs3813865, ra2249695, rs1536826, rs29232, rs2517713, rs2975042, rs3129055, rs3131866, rs22556218, rs10889677, rs6774494, rs243865, rs2285053 and rs9510787. The invention furthermore discloses a PCR amplification primer, a single-base extension primer and a kit of the SNP marker, so as to provide important basis for the illness risk assessment and diagnosis reference of nasopharyngeal cancer.