Traditional Chinese medicine composition for treating alzheimer's disease, and preparation method and application thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating alzheimer's disease, and a preparation method and application thereof. The traditional Chinese medicine composition for treating alzheimer's disease is prepared from the following active pharmaceutical ingredients in parts by weight: 8 to 18 parts of bighead atractylodes rhizome, 10 to 20 parts of longan aril, 3 to 13 parts of colla corii asini, 15 to 25 parts of swimming bladder, 3 to 13 parts of herba patriniae, 5 to 20 parts of humifuse euphorbia herb, 5 to 20 parts of broom cypress fruit, 5 to 20 parts of spica prunellae, 5 to 20 parts of lotus seeds, 3 to 13 parts of spina gleditsiae, 3 to 15 parts of tribulus terrestris and 3 to 13 parts of radix clematidis. The traditional Chinese medicine composition has the efficacies of supplementing qi, nourishing the blood, tonifying the blood and the kidney, clearing away heat, removing dampness and promoting diuresis, tonifying the spleen, eliminating toxin, eliminating wind, dredging collaterals and the like. Meanwhile, the study result on the integral treatment effect of the traditional Chinese medicine composition on alzheimer's disease animal models proves that the traditional Chinese medicine composition is effective on the treatment of the alzheimer's disease, but no side effect exists; therefore by providing the traditional Chinese medicine composition, a novel effective technical measure is provided for the treatment on the alzheimer's disease; wide application prospects are realized in the treatment field of the alzheimer's disease.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition and its preparation method and application, in particular to a traditional Chinese medicine composition for treating Alzheimer's disease, its preparation method and application, and the invention belongs to the technical field of traditional Chinese medicine. Background technique [0002] Alzheimer's disease (Alzheimer's disease, AD) is an senile, degenerative, progressive central nervous system (Central Nervous System, CNS) one of the common diseases (Gontier G, George C, Chaker Z, et al.Blocking IGF Signaling in Adult Neurons Alleviates Alzheimer's Disease Pathology through Amyloid-βClearance[J].J Neurosci,2015,35(33):11500-11513.). AD is mainly manifested as a decline in the learning ability, memory ability, analysis ability, reasoning ability and judgment ability of patients, and it may also be accompanied by mental disorders and blurred consciousness. AD affects the quality of li...

AI Technical Summary

Problems solved by technology

[0007] With the rapid development of science and technology, many drugs for the treatment of AD have appeared clinically, but there are no particularly effective drugs. Many drugs are used to improve the learning and memory of AD, such as acetylcholinesterase (AChE ) inhibitors, anti-neuron cell apoptosis (Apoptosis) drugs, antioxidants, antipsychotic drugs, estrogens, neurotrophic factors (Neurotrophic Factor), neural stem cells (Neural stem cells) and anti-Aβ drugs, etc.

Although the therapeutic effect of these drugs is good, these drugs have certain adverse reactions, which have a certain impact on the physical and mental health of the body. Therefore, it is very important to find effective drugs with small adverse reactions.

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