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A traditional Chinese medicine extract for treating irritable bowel syndrome and its preparation method

A technology for irritable bowel syndrome and extracts, which is applied to pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. Convenient and easy-to-use effects

Active Publication Date: 2020-01-21
吉林天衡药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, traditional Chinese medicine decoctions are more common, and the effect is not obvious. It is urgent to develop Chinese patent medicines for diarrhea-type irritable bowel syndrome, with definite curative effect, safe and stable, and convenient to take.

Method used

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  • A traditional Chinese medicine extract for treating irritable bowel syndrome and its preparation method
  • A traditional Chinese medicine extract for treating irritable bowel syndrome and its preparation method
  • A traditional Chinese medicine extract for treating irritable bowel syndrome and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0163] 1. Prescription of Chinese herbal extracts:

[0164] Cangzhu 333g Chenpi 200g Ginger pinellia 200g

[0165] Magnolia officinalis 200g Huoxiang 200g Poria cocos 200g

[0166] Second, the preparation method:

[0167] (1) Extraction of volatile oil: Atractylodes atractylodes and tangerine peel carbon dioxide supercritical extraction, extraction pressure is 25MPa, extraction temperature is 48°C, extraction time is 2h, CO 2 The flow rate is 20Hz, and the obtained volatile oil is used after dehydration, and the medicinal residues are stored separately;

[0168] (2) Alcohol extraction: take Magnolia officinalis, Ginger pinellia, extract the volatile oil from herbal dregs with Atractylodes atractylodes, dried tangerine peel, etc., add 8 times the amount of 70% ethanol, heat and keep boiling slightly for 1.5 hours, extract twice, and combine the two alcohols The liquid is extracted, left to stand, filtered, and the dregs are used for later use, and the alcohol extract is conc...

Embodiment 2

[0176] 1. Chinese medicine extract tablet prescription:

[0177] Cangzhu 333g Chenpi 200g Ginger pinellia 200g

[0178] Magnolia officinalis 200g Huoxiang 200g Poria cocos 200g

[0179] Second, the preparation method:

[0180] (1) Extraction of volatile oil: Atractylodes atractylodes and tangerine peel carbon dioxide supercritical extraction, extraction pressure is 30MPa, extraction temperature is 36°C, extraction time is 1h, CO 2 The flow rate is 24Hz, and the obtained volatile oil is used after dehydration, and the medicinal residues are stored separately;

[0181] (2) Alcohol extraction: take Magnolia officinalis, Ginger pinellia, extract the volatile oil from herbal dregs with Atractylodes atractylodes, dried tangerine peel, etc., add 6 times the concentration of 80% ethanol, heat and keep boiling for 2 hours, extract 3 times, combine alcohol The liquid is extracted, left to stand, filtered, and the dregs are used for later use, and the alcohol extract is concentrated u...

Embodiment 3

[0186] Traditional Chinese medicine extract capsules: the water extraction extract, alcohol extraction extract, volatile oil β-cyclodextrin inclusion compound and capsules will be prepared according to the steps (1), (2) (3) and (4) of Example 2 Conventional excipients were mixed to prepare filling hard capsules.

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PUM

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Abstract

The invention discloses a traditional Chinese medicine extract for treating the irritable bowel syndrome and a preparation method thereof. According to the traditional Chinese medicine extract, by weight, 1.6-1.8 parts of rhizoma atractylodis, 1 part of pericarpium citri reticulatae, 1 part of rhizoma pinelliae, 1 part of officinal magnolia bark, 1 part of wrinkled gianthyssop herb and 1 part of poria cocos are taken, volatile oil is extracted with the supercritical CO2 technology and included with the beta-cyclodextrin inclusion technology, and optimal technological conditions are selected with the orthogonal design L9(34) test screening alcohol extraction technology and water extraction technology. The traditional Chinese medicine extract has a significant treatment effect on the irritable bowel syndrome and is stable in preparation technology and suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine extract for treating irritable bowel syndrome and a preparation method thereof. Background technique [0002] Irritable bowel syndrome (IBS) is the most common gastrointestinal disorder in clinical practice. It is a syndrome without organic lesions in the gastrointestinal tract. It lacks morphological changes and biochemical abnormalities that can explain symptoms. Persistent or intermittent. The sickness rate of primary disease is high, and has the trend of rising year by year. Its etiology and pathogenesis have not been fully elucidated, and it is generally believed that it is the result of the joint action of multiple pathogenesis. Motherland medicine does not have the disease name of IBS, and according to its clinical manifestations, it belongs to the categories of "abdominal pain", "diarrhea", and "depression...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8888A61K47/69A61P1/00
CPCA61K36/076A61K36/284A61K36/532A61K36/575A61K36/752A61K36/8888A61K2236/331A61K2236/333A61K2236/37A61K2236/39A61K2236/51A61K2300/00
Inventor 濮存海姬珊珊倪正
Owner 吉林天衡药业有限公司
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