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Preparation method of geniposide molecularly imprinted polymer magnetic microspheres

A technology of geniposide molecules and magnetic microspheres, applied in chemical instruments and methods, other chemical processes, etc., can solve the problems of the preparation of geniposide molecularly imprinted polymer magnetic microspheres, which have not been reported, and achieve a small diameter. , high separation efficiency, cheap and easy-to-obtain raw materials

Active Publication Date: 2018-06-22
QILU UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, the preparation of geniposide molecularly imprinted polymer magnetic microspheres has not been reported

Method used

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  • Preparation method of geniposide molecularly imprinted polymer magnetic microspheres
  • Preparation method of geniposide molecularly imprinted polymer magnetic microspheres
  • Preparation method of geniposide molecularly imprinted polymer magnetic microspheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] The preparation method of geniposide molecularly imprinted magnetic microspheres, the steps are as follows:

[0045] (1) Preparation of chitosan magnetic composite microspheres

[0046] Accurately weigh 1.0g chitosan powder, dissolve it in 25mL distilled water containing 2wt% acetic acid, and magnetically stir until completely dissolved to obtain a chitosan solution with a mass concentration of 4%. Add 0.25gNiFe 2 o 4 The nanoparticles were dispersed in the chitosan solution to obtain a stable magnetic fluid, and ultrasonic 15min was used as the dispersed phase. Under the condition of stirring, add the above-mentioned dispersed phase dropwise into the mixed liquid consisting of 125mL liquid paraffin, 1.5gSpan 80 and 1.5gTween 80, emulsify at 25°C for 1h, after 1h, slowly add 1mL glutaraldehyde solution, 70 °C for 1 h, after 1 h, add the same amount of glutaraldehyde, and react at 70 °C for 2 h. After the reaction, the collected N,O-hydroxymethyl chitosan magnetic com...

Embodiment 2

[0052] The preparation method of geniposide molecularly imprinted magnetic microspheres, the steps are as follows:

[0053] (1) Preparation of chitosan magnetic composite microspheres

[0054] Accurately weigh 1.0g chitosan powder, dissolve it in 50mL distilled water, and magnetically stir until it is completely dissolved to obtain a chitosan solution with a mass concentration of 2%. Add 0.20g NiFe 2 o 4 The nanoparticles were dispersed in the chitosan solution to obtain a stable magnetic fluid, and ultrasonic 15min was used as the dispersed phase. Under the condition of stirring, add the above-mentioned dispersed phase dropwise into the mixed solution consisting of 100mL liquid paraffin, 1.0gSpan 80 and 1.0gTween 80, emulsify at 25°C for 1h, after 1h, slowly add 1mL glutaraldehyde solution, 65 °C for 1 h, after 1 h, add the same amount of glutaraldehyde, and react at 65 °C for 4 h. After the reaction, the collected N,O-hydroxymethyl chitosan magnetic composite microspheres...

Embodiment 3

[0060] The preparation method of geniposide molecularly imprinted magnetic microspheres, the steps are as follows:

[0061] (1) Preparation of chitosan magnetic composite microspheres

[0062] Accurately weigh 1.0g chitosan powder, dissolve it in 16mL distilled water, and magnetically stir until completely dissolved to obtain a chitosan solution with a mass concentration of 5.8%. Mix 0.20g NiFe 2 o 4 The nanoparticles were dispersed in the chitosan solution to obtain a stable magnetic fluid, and ultrasonic 15min was used as the dispersed phase. Under the condition of stirring, add the above-mentioned dispersed phase dropwise into the mixed liquid consisting of 150mL liquid paraffin, 2.0gSpan 80 and 2.0gTween 80, emulsify at 25°C for 1h, after 1h, slowly add 1mL glutaraldehyde solution, 80 °C for 1 h, after 1 h, add the same amount of glutaraldehyde, and react at 80 °C for 1 h. After the reaction, the collected N,O-hydroxymethyl chitosan magnetic composite microspheres were ...

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Abstract

The invention relates to a method for preparing geniposide molecularly imprinted polymer magnetic microspheres, comprising the steps: (1), preparing chitosan magnetic composite microspheres; (2), surface-functionalizing the chitosan magnetic composite microspheres; (3), preparing the geniposide molecularly imprinted polymer magnetic microspheres. The geniposide molecularly imprinted polymer magnetic microspheres prepared herein are obtained by reacting in vibration, are uniform in particle size and diameter, and may enable specific separation of geniposide with high efficiency; the microspheres are widely applicable in the catalysis field, separation field, biomedicine field, nanomaterial field and other fields; the preparation method is simple, the raw materials are low in price and easy to obtain, and the cost is low; superparamagnetic nickel ferrite is selected as magnetic nano particles, the preparation process is simple, there is no need for high-temperature calcining, and energy consumption is low.

Description

technical field [0001] The invention relates to a preparation method of geniposide molecularly imprinted magnetic microspheres, belonging to the technical field of molecularly imprinted polymer microspheres preparation. Background technique [0002] Eucommia ulmoides is a plant of the genus Eucommia in the family Eucommia, which is a rare medicinal material in my country. It has various pharmacological effects such as anti-inflammatory and antibacterial, tonifying kidney and lowering blood pressure, enhancing immune function, anti-cancer, anti-fatigue, and anti-aging. Among them, geniposide, geniposide and chlorogenic acid are important biological activities in Eucommia ulmoides Element. At present, there are few reports on the adsorption analysis of these three bioactive components in Eucommia. As the main producing area of ​​Eucommia, my country has very rich resources of Eucommia. [0003] Geniposide is a kind of iridoid glucoside, which is easily soluble in water. It i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F251/00C08F220/06C08F222/14C08K3/22C08J9/26B01J20/26B01J20/06B01J20/30
CPCB01J20/06B01J20/261B01J20/268C08F251/00C08J9/26C08J2351/02C08K3/22C08K2201/011C08F220/06C08F222/14
Inventor 马烽卢金芝董玉欢
Owner QILU UNIV OF TECH
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