Gel-biological ceramic cartilage implant for cartilage replacement repair and preparation method and application thereof

A technology of bioceramics and implants, applied in bone implants, prostheses, tissue regeneration, etc., can solve problems such as the limited source of autologous bone grafts and the immune response of allogeneic bone grafts, so as to prevent further loss, delay age, prepare convenient effect

Inactive Publication Date: 2016-11-09
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of this, the present invention provides a replacement implant for transplanting and repairing cartilage,

Method used

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  • Gel-biological ceramic cartilage implant for cartilage replacement repair and preparation method and application thereof
  • Gel-biological ceramic cartilage implant for cartilage replacement repair and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0065] An embodiment of the present invention provides a method for preparing a gel-hydroxyapatite cartilage implant for cartilage replacement repair, comprising the following steps:

[0066] (1) Construction of hydrogel:

[0067] Put acrylonitrile (180mg), methacryloyloxyethylphosphorylcholine (20mg), cross-linking agent polyethylene glycol diacrylate (100mg, molecular weight 600) into the reaction reagent tube, and use 750μl of dimethyl Sulfoxide (DMSO) was used to dissolve the above reaction reagents, and the ultraviolet photoinitiator Irgacure2959 (6 mg) was added. Inject the reaction system into a transparent and airtight mold with a height of 2 mm, and irradiate the mold in a UV curing box for 20 minutes to carry out a polymerization reaction to obtain a crude hydrogel;

[0068] Then open the mold, take out the gel, rinse it several times with deionized water, and soak it for 7 days, changing the deionized water every 12 hours; dry it after soaking, and use a tissue pun...

Embodiment 2

[0074] A preparation method for a gel-bioceramic cartilage implant for cartilage replacement repair, comprising the steps of:

[0075] (1) Construction of hydrogel:

[0076] Put acrylonitrile (180mg), methacryloyloxyethylphosphorylcholine (20mg), cross-linking agent polyethylene glycol diacrylate (100mg, molecular weight 600) into the reaction reagent tube, and use 750μl of dimethyl Sulfoxide (DMSO) was used to dissolve the above reaction reagents, and the ultraviolet photoinitiator Irgacure2959 (6 mg) was added. Inject the reaction system into a transparent and airtight mold with a height of 2 mm, and irradiate the mold in a UV curing box for 20 minutes to carry out a polymerization reaction to obtain a crude hydrogel;

[0077] Then open the mold, take out the gel, rinse it several times with deionized water, and soak it for 7 days, changing the deionized water every 12 hours; dry it after soaking, and use a tissue puncher to get a hydrogel with a diameter of 6mm .

[0078...

Embodiment 3

[0083] A preparation method for a gel-bioceramic cartilage implant for cartilage replacement repair, comprising the steps of:

[0084] (1) Construction of hydrogel:

[0085] Put acrylonitrile (180mg), methacryloyloxyethylphosphorylcholine (20mg), cross-linking agent polyethylene glycol diacrylate (100mg, molecular weight 600) into the reaction reagent tube, and use 750μl of dimethyl Sulfoxide (DMSO) was used to dissolve the above reaction reagents, and the ultraviolet photoinitiator Irgacure2959 (6 mg) was added. Inject the reaction system into a transparent and airtight mold with a height of 1 mm, irradiate the mold in a UV curing box for 20 minutes, and carry out polymerization reaction to obtain crude hydrogel;

[0086] Then open the mold, take out the gel, rinse it several times with deionized water, and soak it for 7 days, changing the deionized water every 12 hours; dry it after soaking, and use a tissue puncher to obtain a hydrogel with a diameter of 3mm .

[0087] A...

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Abstract

The invention provides a gel-biological ceramic cartilage implant for cartilage replacement repair. The cartilage implant comprises a calcium and phosphorus contained biological ceramic support and hydrogel. One face of the hydrogel and the calcium and phosphorus contained biological ceramic support are bonded together through biological glue, wherein the Young modulus of the hydrogel is 0.2-3 MPa, and the water content is 60-80%; the Young modulus of the calcium and phosphorus contained biological ceramic support is 1-20 GPa, a plurality of holes are formed in the support and the diameter of the holes is 200-600 micrometers. The upper gel of the implant has the mechanical property similar to cartilage, the lower support is matched with the mechanical property of a load bearing component, the function of alternate cartilage replacement repair can be achieved, the tissue fusion can be gradually formed by cartilage and subchondral bones in the bone reconstruction process, and the implant is used for cartilage replacement repair of cartilage defects of the load-bearing component. The invention further provides a preparation method and application of the cartilage implant.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a gel-bioceramic cartilage implant used for cartilage replacement repair and its preparation method and application. Background technique [0002] Arthritis is the most common chronic disease in the world, mainly including osteoarthritis and rheumatoid arthritis. Among them, osteoarthritis, which is characterized by the degeneration of articular cartilage, seriously affects the health and mobility of middle-aged and elderly people. It is due to the imbalance of decomposition and anabolism of chondrocytes, extracellular matrix and subchondral bone tissue, leading to progressive destruction of articular cartilage, loss of cartilage, and arthritis. [0003] At present, the clinical biological treatment methods for repairing articular cartilage damage can reduce or delay the late degeneration of joints and improve the symptoms of articular cartilage damage, which mainly ...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/52A61L27/56A61L27/22A61L27/50C08F283/06C08F220/44C08F230/02C08F2/48A61F2/28
CPCA61L27/12A61F2/28A61F2/30756A61F2/30942A61F2002/2835A61F2002/3006A61F2002/30224A61F2002/30263A61F2002/30968A61L27/18A61L27/227A61L27/50A61L27/52A61L27/56A61L2430/06C08F283/065C08L51/08C08L89/00C08F220/44C08F230/02C08F2/48
Inventor 赵晓丽吕维加
Owner SHENZHEN INST OF ADVANCED TECH
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