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A kind of aqueous solution of gold nanoparticles and its preparation method and application

A gold nanoparticle and aqueous solution technology, applied in the field of nanomaterials, can solve problems such as unfavorable surface functionalization biocompatibility, and achieve the effects of good size monodispersity, wide size range and narrow size distribution

Active Publication Date: 2019-10-08
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

For the research of preparing gold particles of different sizes in one step, it is mostly realized by introducing strong coordination reagents (such as KI) or strong surface ligands (such as PVP, mercapto acid, CTAB, CTAC, etc.) (Perrault S D, Chan W C W.Synthesis and surface modification of highly monodispersed, spherical gold nanoparticles of 50-200nm, J.Am.Chem.Soc., 2009,131:17042-17043; Huang YJ, Kim D-H.Synthesis and self-assembly of highly monodispersed quasispherical gold nanoparticles, 20Langmu ,27:13861-13867; Gao CB,et.al.One-step seeded growth of Au nanoparticles with widely tunable sizes,Nanoscale,2012,4:2875-2878.), but due to the introduction of strong ligands that are difficult to remove on the surface Not conducive to further surface functionalization or maintaining good biocompatibility

Method used

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  • A kind of aqueous solution of gold nanoparticles and its preparation method and application
  • A kind of aqueous solution of gold nanoparticles and its preparation method and application
  • A kind of aqueous solution of gold nanoparticles and its preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0058] In this example, an aqueous solution of gold nanoparticles with an average size of 15 nm was prepared by the following method:

[0059] Add 50mL of tetrachloroauric acid aqueous solution with a concentration of 0.00025M into the jacketed reactor, connect to a constant temperature circulating water bath with a constant temperature of 90°C, place it on a magnetic stirrer for medium-speed and uniform stirring at a stirring speed of 300rpm, and stir at a constant temperature for 15min. Add 10 μL of 3 M KCl aqueous solution (the concentration of potassium ions in the reaction system is 0.0006 M), and continue stirring for 15 min. Quickly inject 1mL of 1wt% sodium citrate aqueous solution into the above reaction system (the concentration of sodium citrate in the reaction system is 0.00068M), and the color of the reaction solution can be observed to change from light yellow-blue black-purple-wine red Process, after continuous constant temperature stirring for 1 h, it was coole...

Embodiment 2

[0062] In this example, an aqueous solution of gold nanoparticles with an average size of 30 nm was prepared by the following method:

[0063] Add 50mL of tetrachloroauric acid aqueous solution with a concentration of 0.0005M into the jacketed reactor, connect to a constant temperature circulating water bath with a constant temperature of 90°C, place it on a magnetic stirrer for medium-speed and uniform stirring at a stirring speed of 300rpm, and stir at a constant temperature for 15min. Aqueous KCl solution was added to make the concentration in the reaction liquid 0.0072M, and stirring was continued for 15 min. Quickly inject 1mL (0.00068M) of 1wt% sodium citrate aqueous solution into the above reaction system, and the color of the reaction solution can be observed to change from light yellow-blue black-purple-wine red. After stirring at a constant temperature for 1 hour, cool naturally to room temperature. After filtering the obtained reaction solution with a water-soluble...

Embodiment 3

[0066] In this example, an aqueous solution of gold nanoparticles with an average size of 50 nm was prepared by the following method:

[0067] Add 50mL of tetrachloroauric acid aqueous solution with a concentration of 0.0005M into the jacketed reactor, connect to a constant temperature circulating water bath with a constant temperature of 90°C, place it on a magnetic stirrer for medium-speed and uniform stirring at a stirring speed of 300rpm, and stir at a constant temperature for 15min. A KCl aqueous solution was added to make the concentration in the reaction liquid 0.0096M, and stirring was continued for 15 min. Quickly inject 1mL (0.00068M) of 1wt% sodium citrate aqueous solution into the above reaction system, and the color of the reaction solution can be observed to change from light yellow-blue black-purple-wine red. After stirring at a constant temperature for 1 hour, cool naturally to room temperature. After filtering the obtained reaction solution with a water-solub...

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Abstract

The invention provides a method for preparing an aqueous solution of gold nanoparticles, the method comprising the following steps: dissolving gold salt in deionized water, placing it in a reactor, reacting at a constant temperature, adding alkali metal ions, and forming a gold precursor solution ; Add the weak reducing agent into the gold precursor solution, continue the constant temperature reaction, and after the reaction, obtain the gold nanoparticle aqueous solution through post-processing. The preparation method of the gold nanoparticle aqueous solution of the present invention is simple, has good repeatability, and is easy to be synthesized in large quantities; the size range of the gold nanoparticles is wide, and the size distribution is narrow to monodisperse, which can meet the requirements of colloidal gold nanoparticle in the field of immunoassay, biological detection or clinical diagnosis. Different requirements for particle size; the ligand molecules on the surface of gold nanoparticles are water-soluble small molecules, which have good biocompatibility and are easy to carry out further specific modification; and the electronegativity of the surface of gold nanoparticles is negative, which is Cells and tissues, etc. have low biological toxicity.

Description

technical field [0001] The invention belongs to the technical field of nanomaterials, and relates to an aqueous solution of gold nanoparticles and a preparation method and application thereof, in particular to a monodisperse aqueous solution of gold nanoparticles with different sizes and a preparation method and application thereof. Background technique [0002] Colloidal gold nanoparticles have important applications in the fields of catalysis, biomarkers, nonlinear optical devices, biomedicine, and drug delivery due to their high electron density, dielectric properties, catalytic properties, and good biocompatibility (Pal R, et.al.Charaterization of citrate capped gold nanoparticle-quercetin complex:experimental and quantum chemical approach.J.Mol.Struct.2013,1046:153-163.;Daniel MC,Astruc D.Gold nanoparticles:assembly,supramolecular chemistry,quantum -size-related properties, and applications toward biology, catalysis and nanotechnology.Chem.Rev.2004,104:293-346.; Verma H...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B22F9/24B22F1/00B82Y40/00
CPCB82Y40/00B22F9/24B22F1/0545
Inventor 刘忍肖葛广路
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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