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Method for extracting ursolic acid from loquat leaves

A technology of loquat leaves and ursolic acid, applied in the field of medicine, can solve the problems of long extraction time and low extraction rate of ursolic acid, and achieve the effects of short extraction time, less loss of effective components and low pollution

Inactive Publication Date: 2016-11-16
重庆希尔安药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above methods all have defects such as longer extraction time and lower extraction rate of ursolic acid

Method used

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  • Method for extracting ursolic acid from loquat leaves
  • Method for extracting ursolic acid from loquat leaves
  • Method for extracting ursolic acid from loquat leaves

Examples

Experimental program
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Effect test

Embodiment 1

[0056] Wash 1 kg of loquat leaves, dry them, and crush them into 40 meshes; add 8 times the weight of loquat leaves to the coarse powder of loquat leaves, soak for 0.5 hours at a temperature of 200°C, and infiltrate water at a speed of 5L / h, the extraction time was 45min, and the pressure was 10MPa. The leachate was collected and concentrated to a ointment with a relative density of 1.10 at 60°C. The extraction rate of ursolic acid was determined to be 64.24%.

Embodiment 2

[0058] Wash 1 kg of loquat leaves, dry them, and crush them into 60 meshes; add water 10 times the weight of loquat leaves to the coarse powder of loquat leaves, soak for 1 hour at a temperature of 200°C, and infiltrate water at a speed of 5L / h, the extraction time was 60min, and the pressure was 10MPa. The leachate was collected and concentrated to a ointment with a relative density of 1.10 when concentrated to 60°C. The extraction rate of ursolic acid was determined to be 70.62%.

Embodiment 3

[0060] Wash 1 kg of loquat leaves, dry them, and crush them into 80 meshes; add water 12 times the weight of loquat leaves to the coarse powder of loquat leaves, soak for 1 hour, the temperature is 200 °C, and the percolation water speed is 5L / h, the extraction time was 75min, and the pressure was 10MPa. The leachate was collected and concentrated to a ointment with a relative density of 1.20 at 60°C. The extraction rate of ursolic acid was measured to be 71.18%.

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Abstract

The invention provides a method for extracting ursolic acid from loquat leaves, and relates to the technical field of medicine. According to the method, the loquat leaves are taken as raw materials, a technique and technology for extracting and separating ursolic acid from the loquat leaves under the undercritical condition by taking water as a solvent are adopted, therefore, the extraction rate and the purity of ursolic acid are increased, the high-efficiency extraction effect of sequentially extracting functional factors in the loquat leaves in a grading mode is achieved, and ursolic acid with the high purity is obtained.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a method for extracting ursolic acid from loquat leaves. Background technique [0002] China is the most important producer of loquat in the world. The cultivated area and output of loquat account for more than 2 / 3 of the global total. The whole body of loquat is full of treasures. Loquat leaves, flowers, fruits, cores and other parts are rich in triterpene acids (up to 1.5%) ), volatile oil, amygdalin, saponins, flavonoids, water-soluble polysaccharides and organic acids and other active ingredients. At present, loquat is mainly supplied with fresh fruit, and the in-depth development and comprehensive utilization of other parts have not yet been carried out. [0003] Loquat leaf is a traditional Chinese medicine in my country. It has the effects of resolving phlegm, relieving cough, harmonizing the stomach, and has pharmacological effects such as anti-tumor, anti-virus, loweri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J63/00
CPCC07J63/008
Inventor 吕珊珊谯志文周年华陈晓雪杨超李建华陈小红
Owner 重庆希尔安药业有限公司