Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Dandelion granules and traditional Chinese medicine preparation thereof

A dandelion and granule technology, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc., can solve problems such as the inability to analyze multiple varieties and batches of samples in real time, the physical injury of inspectors, and the lag in information feedback. Achieve the effect of process parameters and easy control, high accuracy and stable process parameters

Active Publication Date: 2016-11-23
GUANGDONG YIFANG PHARMA
View PDF1 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the quality of traditional Chinese medicine formula granules will also be restricted by detection methods. The traditional determination of moisture and ethanol extracts in dandelion granules requires several hours by referring to the pharmacopoeia, and the operation is more complicated.
The main chemical component of dandelion granules is caffeic acid. As a quality control indicator, the traditional method uses high-performance liquid chromatography, etc., which often requires complicated pretreatment of samples, consumes a lot of reagents, and pollutes the environment and inspectors. The body is damaged, and the information feedback is lagging behind, which cannot meet the needs of real-time analysis of multi-variety and multi-batch samples in the process of large-scale production of granule enterprises

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Dandelion granules and traditional Chinese medicine preparation thereof
  • Dandelion granules and traditional Chinese medicine preparation thereof
  • Dandelion granules and traditional Chinese medicine preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Preparation of dandelion granules: take dandelion decoction pieces, add water to decoct 3 times, add 8 times the amount of water each time, heat and decoct for 1.5 hours each time; combine the medicinal liquids, concentrate the filtrate to a clear paste with a relative density of 1.08 (80°C), Filtrate with a 350-mesh sieve while it is hot; spray dry under the conditions of air inlet temperature 175°C, material pump speed 500 rpm, outlet air temperature 90°C, and air supply temperature 40°C to obtain spray-dried powder; The hole diameter is 1.50mm, the roller motor frequency is 40HZ, the feeding motor frequency is 45HZ, and the oil cylinder pressure is 20bar under the conditions of dry granulation to obtain dandelion particles with a particle size of 40 mesh.

Embodiment 2

[0036] Preparation of traditional Chinese medicine preparations containing dandelion granules: Preparation of dandelion granules: take dandelion decoction pieces, add water to decoct 3 times, add 8 times the amount of water each time, heat and decoct for 1.5 hours each time; combine the medicinal liquids, and concentrate the filtrate to a relative density of 1.08 (80°C) clear paste, filter it with a 350-mesh sieve while it is hot; spray dry under the conditions of air inlet temperature 175°C, material pump speed 500 rpm, outlet air temperature 90°C, and air supply temperature 40°C , to spray dry powder; dry granulation under the conditions of punching plate aperture 1.50mm, roller motor frequency 40HZ, feeding motor frequency 45HZ, oil cylinder pressure 20bar, to obtain dandelion granules with a particle size of 40 mesh; mix 175g dandelion granules with 65g maltodextrin Mix well, add appropriate amount of magnesium stearate, mix well, and press into 1000 tablets.

Embodiment 3

[0038] A method for rapidly detecting the moisture content of dandelion particles based on near-infrared spectroscopy, specifically comprising the steps of:

[0039] a. Take dandelion particle samples, a total of 82 batches, about 3g each, grind into fine powder, put it into a stoppered glass sample bottle, place it on a near-infrared scanner for scanning, collect spectra, scanning conditions: scanning range 4000 -12000cm -1 , number of scans: 32 times, resolution 8cm -1 , the background is subtracted in real time during the scanning process, and 3 spectra are collected for each sample to obtain the following figure 1 The near-infrared original absorption spectrum figure of 82 batches of dandelion particles shown;

[0040] At the same time, according to the standard method stipulated in the 2015 edition of the Chinese Pharmacopoeia, its moisture content was determined by the drying method. About 2 g of dandelion particles ground into fine powder were spread in flat weighing ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention discloses dandelion granules and a traditional Chinese medicine preparation thereof. The dandelion granules are prepared through the method, and the method includes the steps that dandelion decoction pieces are taken, water is added to decoct the dandelion decoction pieces for 2-3 times, water of 5-10 times amount is added each time, and heating decocting is carried out for 1-2 h each time; decoction liquor are combined, filter liquor is concentrated to clear paste with the relative density of 1.02-1.12, and the clear paste is filtered through a screen of 250-350 mesh while the clear paste is hot; spray drying is carried out on the clear paste to obtain spray dry powder; dry granulation is carried out on the spray dry power to obtain the dandelion granules with the granularity of 16-40 mesh. The dandelion granules are simple in preparation process, process parameters are easy to control, and a detection method is scientific, fast and high in operability.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, in particular to a dandelion granule and a traditional Chinese medicine preparation containing the dandelion granule. Background technique [0002] Dandelion is the dry whole plant of Compositae Taraxacum mongolicum Hand.-Mazz., Taraxacum borealisinense Kitam. or several plants of the same genus. It is bitter, sweet and cold, and returns to the liver and stomach meridian. knot, the effect of inducing diuresis and treating stranguria. The medicinal part of dandelion is the whole herb, which is not convenient for storage. The appearance of granules solves this problem very well. [0003] Traditional Chinese medicine granules are a series of traditional Chinese medicine products made of traditional Chinese medicine decoction pieces that meet the processing specifications, which are extracted, concentrated, dried, and granulated by modern industry. The new form of ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/359G01N21/3563A61K36/288A61K9/16
CPCA61K9/1605A61K36/288A61K2236/331A61K2236/39A61K2236/51G01N21/3563G01N21/359
Inventor 陈向东朱德全赵径华刘丽萍霍文杰谭登平程学仁
Owner GUANGDONG YIFANG PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com